Avaliação da estabilidade na contagem de ovos de Schistosoma mansoni pelo método de Kato-Katz em uma zona endêmica da esquistossomose

Cell-mediated immunity to Schistosoma mansoni antigens, unrelated antigens and mitogens was evaluated in 50 subjects with the same degree of exposure to infection living in an endemic area of schistosomiasis. The degree of infection, assessed by the number of eggs/g of stool, was variable in this population (0-5604), suggesting differences in susceptibility to infection. Absence of lymphoproliferative response was observed in 56% of this group, despite having a response to purified protein derivative of tuberculin (PPD) and tetanus toxoid (TT) antigens and to pokeweed mitogen. The 50 subjects were divided into two groups, according to their degree of infection. The lymphoproliferative responses to schistosomula and adult worm antigens in the group with a low degree of infection (< 400 eggs/g of stool) were higher than the ones documented in patients with a high degree of infection (> 400 eggs/g of stool), and these differences were statistically significant (p < 0.001). An inverse correlation between the lymphocyte proliferation in response to S. mansoni antigens and the degree of infection was also observed (p = 0.02), indicating that subjects with a lower degree of infection have a higher lymphoproliferative response to schistosomula and adult worm antigens. No differences in the lymphocyte reactivity to other antigens (PPD and TT) were detected in these groups. An impairment of interferon-gamma in vitro production was observed when the lymphocytes from these subjects were stimulated with S. mansoni adult worm antigen, although they produced gamma interferon in response to phytohemagglutinin.

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Comparison between schistosomiasis transmission modelings considering acquired immunity and age-structured contact pattern with infested water

Yang

2003

Mathematical Biosciences

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Avaliação da estabilidade na contagem de ovos de Schistosoma mansoni pelo método de Kato-Katz em uma zona endêmica da esquistossomose

Abstract: M aria F e rn a n d a F. d e Lim a e C o s ta 1, R.S. R o ch a 2 e N a fta le K atz2 (556,6 + 4,4 ovos/g fezes).Palavras chaves: Esquitossomose mansoni. Schistosom a m ansoni. Exame de fezes. M étodo de K ato-K atz.

Cited by 5 publications

References 6 publications

Interventions for treating schistosomiasis mansoni

Interventions for treating schistosomiasis mansoni

Correlation between cell‐mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis

Comparison between schistosomiasis transmission modelings considering acquired immunity and age-structured contact pattern with infested water

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