Trypanosoma cruzi no colostro humano

Medina-Lopes, Maria das Dores; Macêdo, Vanize

doi:10.1590/s0037-86821983000300010

Cited by 9 publications

(6 citation statements)

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“…Considering the above mentioned studies and reports by Mazza et al 14 and Medina-Lopes 15 who described the presence of T. cruzi in human colostrum of patients with acute form of the disease and, later, the report by Medina-Lopes 16 on a case of T. cruzi detected in a breast-feeding mother in the chronic phase of disease, it was decided to undertake this research to assess the incidence of T. cruzi transmission through breastfeeding during acute experimental Chagas disease.…”

Section: Introductionmentioning

confidence: 82%

Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease

Martins¹,

Castanho²,

Nogueira³

et al. 2011

Braz J Infect Dis

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Section: Introductionmentioning

confidence: 82%

Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease

Martins¹,

Castanho²,

Nogueira³

et al. 2011

Braz J Infect Dis

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“…It has been considered that acutely infected mothers who were breastfeeding could potentially transmit the parasite orally from their breast milk [ 87 ]. Trypomastigotes have been found in the breast milk of several mothers that were in the acute and chronic phase through direct examination of the parasite; however, only one has been seen positive using xenodiagnoses, suggesting it to be unlikely to transmit the infection orally [ 88 , 89 , 90 ]. Some authors suggest that breast milk is a poor mechanism of transmission and that breast milk could potentially become cross-contaminated in mothers who have bleeding nipples and not from the milk itself [ 88 ].…”

Section: T Cruzi Contaminated Food and Drinkmentioning

confidence: 99%

Oral Chagas Disease in Colombia—Confirmed and Suspected Routes of Transmission

Beatty,

Arango-Ferreira,

Gual-Gonzalez

et al. 2024

TropicalMed

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Chagas disease (CD) remains endemic throughout many regions of Colombia despite implementing decades of vector control strategies in several departments. Some regions have had a significant decrease in vectorial transmission, but the oral ingestion of Trypanosoma cruzi through consumption of contaminated food and drink products is increasingly described. This form of transmission has important public health relevance in Colombia due to an increase in reported acute CD cases and clinical manifestations that often lead to significant morbidity and mortality. Oral CD in Colombia has been associated with the consumption of contaminated fruit juices, such as palm wine, sugar cane, or tangerine juice and water for consumption, or contaminated surfaces where food has been prepared. Another interesting route of oral transmission includes ingestion of unbeknownst infected armadillos’ blood, which is related to a traditional medicine practice in Colombia. Some earlier reports have also implemented consumption of infected bush meat as a source, but this is still being debated. Within the Amazon Basin, oral transmission is now considered the principal cause of acute CD in these regions. Furthermore, new cases of acute CD are now being seen in departments where CD has not been documented, and triatomine vectors are not naturally found, thus raising suspicion for oral transmission. The oral CD could also be considered a food-borne zoonosis, and odoriferous didelphid secretions have been implemented in contaminating the human dwelling environment, increasing the risk of consumption of infectious metacyclic trypomastigotes. In this article, we will discuss the complex transmission dynamics of oral CD in Colombia and further examine the unique clinical manifestations of this route of infection. New insights into the oral transmission of Trypanosoma cruzi are being discovered in Colombia, which can help bring increased awareness and a better understanding of this neglected tropical disease to reduce the burden of CD throughout Latin America.

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“…Because T. cruzi, originally named Schyzotrypanum cruzi, possesses the capacity to cross the epithelium and to infect via the oral route [29,327,329], the presence of this pathogen in the milk has been searched for. T. cruzi was found in the milk of experimentally infected mice [328,330,331], and several reports describe the presence of this pathogen in the milk from pregnant women [332][333][334][335], as reviewed by Norman and Lopez-Vélez [336]. In most cases, the presence of T. cruzi in the milk of pregnant women has been attributed to contamination by infected blood due to nipple bleeding [336].…”

Section: Milkmentioning

confidence: 99%

Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

Sereno

Akhoundi

Sayehmri

et al. 2020

IJMS

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Unicellular eukaryotes of the Trypanosomatidae family include human and animal pathogens that belong to the Trypanosoma and Leishmania genera. Diagnosis of the diseases they cause requires the sampling of body fluids (e.g., blood, lymph, peritoneal fluid, cerebrospinal fluid) or organ biopsies (e.g., bone marrow, spleen), which are mostly obtained through invasive methods. Body fluids or appendages can be alternatives to these invasive biopsies but appropriateness remains poorly studied. To further address this question, we perform a systematic review on clues evidencing the presence of parasites, genetic material, antibodies, and antigens in body secretions, appendages, or the organs or proximal tissues that produce these materials. Paper selection was based on searches in PubMed, Web of Science, WorldWideScience, SciELO, Embase, and Google. The information of each selected article (n = 333) was classified into different sections and data were extracted from 77 papers. The presence of Trypanosomatidae parasites has been tracked in most of organs or proximal tissues that produce body secretions or appendages, in naturally or experimentally infected hosts. The meta-analysis highlights the paucity of studies on human African trypanosomiasis and an absence on animal trypanosomiasis. Among the collected data high heterogeneity in terms of the I 2 statistic (100%) is recorded. A high positivity is recorded for antibody and genetic material detection in urine of patients and dogs suffering leishmaniasis, and of antigens for leishmaniasis and Chagas disease. Data on conjunctival swabs can be analyzed with molecular methods solely for dogs suffering canine visceral leishmaniasis. Saliva and hair/bristles showed a pretty good positivity that support their potential to be used for leishmaniasis diagnosis. In conclusion, our study pinpoints significant gaps that need to be filled in order to properly address the interest of body secretion and hair or bristles for the diagnosis of infections caused by Leishmania and by other Trypanosomatidae parasites.

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Trypanosoma cruzi no colostro humano

Abstract: Estamos relatando à comunidade científica 04/83, foi inoculado em camundongos, por via a comprovação pela primeira vez da presença de intraperitoneal, e 10 dias após os xenodiagnósti-T. cruzi no colostro hum ano.cos foram positivos.

Cited by 9 publications

References 0 publications

Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease

Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease

Oral Chagas Disease in Colombia—Confirmed and Suspected Routes of Transmission

Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

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