Alteração da resposta imune mediada por células durante o tratamento com Benzonidazol

Teixeira, Antônio R. L.; Jabur, Eliane; Córdoba, José Carlos; Maior, Inês C Souto; Solórzano, Edwin

doi:10.1590/s0037-86821983000100003

Cited by 7 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both drugs achieve elimination of the T. cruzi infections in vitro but they fail to eradicate the live infections in experimental animals and in man [38,40,66,67], possibly, because after-treatment non-phagocyte growing nest sustains the persisting parasite infection. The nitro-derivatives toxicity includes mutagenic, teratogenic, carcinogenic and sterilizing activities [68][69][70][71][72][73][74][75][76], which relies on the pteridine reductase activity [85][86][87][88][89][90]…”

Section: Drug Developmentmentioning

confidence: 99%

Prevention and Control of Chagas Disease – An Overview

Teixeira¹,

Gomes

Rosa³

et al. 2018

ISRR

View full text Add to dashboard Cite

Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high

show abstract

Section: Drug Developmentmentioning

confidence: 99%

Prevention and Control of Chagas Disease – An Overview

Teixeira¹,

Gomes

Rosa³

et al. 2018

ISRR

View full text Add to dashboard Cite

show abstract

“…In experimental studies the use of benzonidazol has been associated with the appearance of lymphomas in up to 30% of rats with Chagas' disease. It is not known whether in humans the incidence of lymphomas increases with the use of benzonidazol, but this drug may cause damage to cellular immunity (27). Concerning the immunological aspects of Chagas' disease, experimental trials demonstrate that T. cruzi infection induces immunological disturbances at cellular and humoral levels.…”

Section: Neoplasiasmentioning

confidence: 99%

Heart transplants for patients with Chagas' heart disease

Bocchi

1995

Sao Paulo Med. J.

View full text Add to dashboard Cite

The role of heart transplants for treating Chagas' heart disease is not quite clear. Immunosuppression could lead to resurgence of T. cruzi infection with acute or chronic damage to the allograft. There are few publications regarding this issue. Thus we reported the follow-up of 18-patients with Chagas' heart disease submitted to orthotopic heart transplants from 1985 to 1993 at The Heart Institute. The patients were in functional class IV or II, with sustained ventricular tachycardia episodes. The mean left ventricular ejection fraction was 25 +/- 9% and the mean right ventricular ejection was 22 +/- 5% (MUGA). Immunosuppression was based on cyclosporin, azathioprine and corticosteroid. For specific post-transplant monitoring of T. cruzi infection, blood tests were performed (examination of blood or leukocyte concentrate, Giemsa-stained blood smears, blood culture, xenodiagnosis, mouse inoculation) and tissue biopsy (skin or myocardium). In addition, complement fixation hemagglutination and immunofluorescence assays were performed. T. cruzi parasitemias were detected in 18 circumstances in 13 patients. Resurgence of Chagas' disease was diagnosed in 11 circumstances in 5 patients. Fever, subcutaneous nodules and myocarditis predominated in these episodes. All episodes of parasitemia and Chagas' disease resurgence were successfully treated with benzonidazole. Al surviving patients had normal cardia function despite left ventricular function worsening during some myocarditis episodes. Neoplasias were important findings and 3 patients developed lymphoproliferative disease, 2 developed Karposi's sarcoma and 1 patient developed skin cancer. The survival rates of 4 and 12 months were 83% and 49% respectively. The survival of patients who underwent heart transplants from August 1991 to April 1993 was 100% at 4 months and 75% at 12 months. Heart transplants for Chagas' heart disease may be associated with episodes of parasitemia and a reoccurrence of episodes of Chaga's disease. The survival of heart transplanted patients has improved when associated with lower doses of cyclosporins and thus, fewer resurgences of the disease.

show abstract