Imunização de camundongos com «vacina» viva avirulenta de Trypanosoma cruzi: II Ensaio da avaliação do tempo de eficiência da vacina

Menezes, H

doi:10.1590/s0037-86821970000100001

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“…Procuram os em trab alh o s anteriores dem o n strar experim en talm en te qual o m e nor inóculo capaz de conferir eficiente proteção a cam undongos (8) e qual o tem po m áxim o de proteção que se pode conseguir nessa espécie de anim al con tra um a infecção por form as v iru len tas de T. cruzi (7).…”

Section: Parcisitemia E O Exame Histológico Revelaram Que Aparentemeunclassified

Imunização de camundongos com "vacina" viva avirulenta de Trypanosoma cruzi: IV. ensaio de esquema de "vacinação"[ign]

Menezes¹

1970

Rev. Soc. Bras. Med. Trop.

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A parasitemia e o exame histológico revelaram que, aparentemente camundongos que receberam duas doses de "vacina" reagiram melhor a vma infecção virulenta do T. cruzi do que animais "vacinados'' uma única vez. Nestes a infecção realizada quatro ou dez semanas depois da imunização não alterou substancialmente a resposta imunitária medida pela parasitemia, percentual de mortalidade e grau da resposta tissular. Animais unicamente "vacinados", com uma ou duas doses, não apresentaram alterações histológicas diferentes das dos animais normais. Êstes mostraram quase sempre um discreto grau de inflamação crônica focal no miocáráio, e fígado.

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Section: Parcisitemia E O Exame Histológico Revelaram Que Aparentemeunclassified

Imunização de camundongos com "vacina" viva avirulenta de Trypanosoma cruzi: IV. ensaio de esquema de "vacinação"[ign]

Menezes¹

1970

Rev. Soc. Bras. Med. Trop.

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Relationship Between Long-Term Resistance to Trypanosoma Cruzi and Latent Infection, Examined by Antibody Production and Polymerase Chain Reaction in Mice

Basombrío

Segura

Nasser

2002

Journal of Parasitology

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Trypanosoma cruzi infections persist for the lifetime of humans and laboratory animals as either latent or pathogenic parasitism. Mice inoculated with a nonpathogenic, attenuated strain (TCC) display resistance against virulent challenge, with a strong control of parasitemia and protection against tissue lesions for more than 12 mo. Three main approaches were used to test whether protection by TCC inocula is based on a latent infection or on a "sterile" immunological memory: curative Benznidazole (Bzl) treatment, serological reactions, and detection of infection by polymerase chain reaction (PCR). If resistance is maintained in the absence of infection, it should not be reduced by Bzl treatment and TCC-inoculated animals should not maintain long-term serological or PCR reactivity. The Bzl treatment after TCC inoculations did not reduce, after periods of up to 420 days, TCC-induced resistance to challenge. But TCC inocula given during Bzl treatment conferred short-term, but not long-term. protection. Maintenance of high antibody levels and protection were better in the virulent Tulahuen (TUL) strain than in the attenuated TCC strain infections, and trypomastigote inocula of either strain were better inducers of antibodies and resistance than epimastigotes. PCR detection of T. cruzi DNA was positive in almost all TUL strain-inoculated animals and negative in immunocompetent animals inoculated with TCC epimastigotes, although high numbers of TCC trypomastigotes produced persistent PCR signals of infection in newborn BALB mice. Thus, 2 polar models were developed, where latent infection by TCC was either demonstrated or excluded. In both, resistance to virulent challenge was maintained during long periods. But late declination of antibody titers (>200 days) and resistance to challenge (>350 days) was observed in animals displaying clearance of all signals of infection.

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Imunização de camundongos com «vacina» viva avirulenta de Trypanosoma cruzi: II Ensaio da avaliação do tempo de eficiência da vacina

Cited by 2 publications

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Imunização de camundongos com "vacina" viva avirulenta de Trypanosoma cruzi: IV. ensaio de esquema de "vacinação"[ign]

Imunização de camundongos com "vacina" viva avirulenta de Trypanosoma cruzi: IV. ensaio de esquema de "vacinação"[ign]

Relationship Between Long-Term Resistance to Trypanosoma Cruzi and Latent Infection, Examined by Antibody Production and Polymerase Chain Reaction in Mice

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