Human Infection With Avian Influenza a (H7n9) Virus

Zhang, Yi; Yu, Yehua; Tang, Zisheng; Chen, Xiaohua; Zang, Guoqing

doi:10.1590/s0036-46652014000400019

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Furthermore, this study demonstrated that the median age of patients with A (H7N9) infection was 56 (range, 1 to 88) years, most cases occurred in the 60-to 79year-old group, and the proportion of fatal cases was higher than nonfatal cases in patients more than 60 years old. These results are consistent with those prior studies which found that the elderly have an increased risk for A (H7N9) infections (Zhang et al, 2014;Wang et al, 2016). In contrast, influenza A (H5N1) has infected mainly younger people, but the mechanism for the different age distributions of humans with A (H5N1) and A (H7N9) infections is still unclear.…”

Section: Discussionsupporting

confidence: 92%

Epidemiological and clinical characteristics of humans with avian influenza A (H7N9) infection in Guangdong, China, 2013–2017

Yang

Zhong

Song

et al. 2017

International Journal of Infectious Diseases

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Section: Discussionsupporting

confidence: 92%

Epidemiological and clinical characteristics of humans with avian influenza A (H7N9) infection in Guangdong, China, 2013–2017

Yang

Zhong

Song

et al. 2017

International Journal of Infectious Diseases

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“…This could possibly be an even worse threat than H1N1because H7N9 is a low pathogenic avian influenza virus. All pandemics so far have been caused by low pathogenic viruses, and not by high pathogenic viruses (54). In 2014, severe dengue fever outbreaks occurred, which posed a substantial socioeconomic burden, with 46,864 cases being reported nationwide (50).…”

Section: Health Problems In Chinamentioning

confidence: 99%

One Health in China

Liu

Wang

et al. 2016

Infection Ecology & Epidemiology

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As a result of rapid economic growth over the previous three decades, China has become the second largest economy worldwide since 2010. However, as a developing country with the largest population, this rapid economic growth primarily based on excessive consumption and waste of resources. Thus, China has been facing particularly severe ecological and environmental problems in speeding up industrialization and urbanization. The impact of the health risk factors is complex and difficult to accurately predict. Therefore, it is critical to investigate potential threats in the context of the human-animal-environment interface to protect human and animal health. The “One Health” concept recognizes that human health is connected to animal and environmental health. This review primarily discusses specific health problems in China, particularly zoonoses, and explains the origin and development of the One Health approach, as well as the importance of a holistic approach in China.

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“…Avian influenza virus (AIV) is a worldwide pathogen, causing infection in poultry and even human beings by H5, H7, and H9 subtype viruses . Based on the genetic features and the severity of the disease in poultry, AIV can be classified as highly pathogenic avian influenza virus (HPAIV) strains and low pathogenic avian influenza virus (LPAIV) strains .…”

Section: Introductionmentioning

confidence: 99%

H9 subtype influenza vaccine in MDCK single‐cell suspension culture with stable expression of TMPRSS2: Generation and efficacy evaluation

Feng

Tang

et al. 2016

Engineering in Life Sciences

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Vaccination is the most effective way to protect chickens from avian influenza pandemics. Mammalian cells, especially MDCK cells, are being investigated as a good alternative to the embryonated chicken eggs for avian influenza vaccine production. In this work, we developed a new MDCK cell line, which has two main features: single‐cell suspension growth and stable expression of human TMPRSS2 protein (transmembrane protease serine S1 member 2) anchored on cells membrane, named MDCK‐Sus‐TMPRSS2. Reverse‐transcription polymerase chain reaction, western blot analysis and indirect immunofluorescence assay were employed to detect the expression of TMPRSS2 in the MDCK‐Sus‐TMPRSS2 cells. Then, H9 subtype avian influenza virus, NJ02/01 strain, was adapted in MDCK‐Sus‐TMPRSS2 cells with serial blind passages and propagated in stirred bioreactor with 9.5 log2/25 μL hemagglutination titers for inactivated avian influenza vaccine production without addition of exogenous trypsin. The MDCK‐Sus‐TMPRSS2 cell‐derived H9 subtype avian influenza vaccine could induce high titers of hemagglutiniton inhibition antibodies in specific pathogen‐free chickens and protect chickens against heterologous H9 subtype influenza virus challenge, showing lower virus shedding rate and sickness rate than in the egg‐derived vaccines group. High titers of H9 subtype‐specific antibodies above 6 log2 were maintained for 6 months in commercial chickens vaccinated by the MDCK‐Sus‐TMPRSS2 cells derived H9 subtype avian influenza vaccine and there were no negative effects on body weight increase in these chickens. Taken together, the results of this work revealed that MDCK‐Sus‐TMPRSS2 cell line could be a promising and safe substitute for embryonated chicken eggs as a host cell line for H9 subtype avian influenza virus propagation.

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Human Infection With Avian Influenza a (H7n9) Virus

Cited by 7 publications

References 9 publications

Epidemiological and clinical characteristics of humans with avian influenza A (H7N9) infection in Guangdong, China, 2013–2017

Epidemiological and clinical characteristics of humans with avian influenza A (H7N9) infection in Guangdong, China, 2013–2017

One Health in China

H9 subtype influenza vaccine in MDCK single‐cell suspension culture with stable expression of TMPRSS2: Generation and efficacy evaluation

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