FUNGEMIA CAUSED BY Candida SPECIES IN A CHILDREN'S PUBLIC HOSPITAL IN THE CITY OF SÃO PAULO, BRAZIL: STUDY IN THE PERIOD 2007-2010

Abstract

Candidemia remains a major cause of morbidity and mortality in the health care environment. The epidemiology of Candida infection is changing, mainly in relation to the number of episodes caused by species C. non-albicans. The overall objective of this study was to evaluate the frequency of yeasts of the genus Candida, in a four-year period, isolated from blood of pediatric patients hospitalized in a public hospital of the city of São Paulo, Brazil. In this period, yeasts from blood of 104 patients were isolated and, the identified species of Candida by phenotypic and genotypic methods were: C. albicans (39/104), C. tropicalis (25/104), C. parapsilosis (23/104), Pichia anomala (6/104), C. guilliermondii (5/104), C. krusei (3/104), C. glabrata (2/104) and C. pararugosa (1/104). During the period of the study, a higher frequency of isolates of C. non-albicans (63.55%) (p = 0.0286) was verified. In this study we verified the increase of the non-albicans species throughout the years (mainly in 2009 and 2010). Thus, considering the peculiarities presented by Candida species, a correct identification of species is recommended to lead to a faster diagnosis and an efficient treatment.

Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey

“…In the light of several reports, it can be said that although CA alone remains the most common, prevalence of nosocomial candidiasis because of NAC has been increasing. [20][21][22][23] This shift has been attributed to the increase in the number of patients with severe immunosuppression, use of prophylactic antifungals in these high-risk patients, prolonged use of broad-spectrum antibiotics, prematurity, and invasive medical procedures. 24,25 NAC species were more frequently isolated in our study than CA (53% vs 47%, respectively) as well.…”

“…The rank order of species in cases of candidemia were the same, in accordance with some pediatric series, 12,21,28 whereas contrasting with some other. 14,16,23 The increase in the rate of C parapsilosis among bloodstream isolates (from 13% in all systemic candidiasis episodes to 22.2% in candidemia episodes) was substantial. The high transmission rate of C parapsilosis among candidemia patients was reported before.…”

Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei

“…Moreover, the number of candidemia cases caused by non-albicans Candida species has been increasing in recent years (5)(6)(7). It is known that the treatment of some Candida species is difficult because of their innate or acquired resistance to antifungal agents (8)(9)(10). For instance, Candida krusei is intrinsically resistant to fluconazole (1,11).…”

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA†

“…Some of the reports deemed relevant in the ELS (16) reported W. anomalus / C. pelliculosa among fungi (mainly Candida spp.) isolated from patients with various serious underlying diseases and suffering infections by opportunistic microbes (Kuiper et al., ; Oliveira et al., ; Taj‐Aldeen et al., ; Lin et al., ; Nidhi et al., ; Tzar et al., ). Additionally, W. anomalus was always a minor fraction (less than 10%) of the isolates.…”