Varicella emergency vaccination seemed instrumental in declining chickenpox incidente in Guangzhou, Southern China

Li, Tiegang

doi:10.1590/s0036-46652013000300016

Cited by 8 publications

(9 citation statements)

References 7 publications

(3 reference statements)

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“…In recent years, varicella has accounted for significant morbidity and remains a public health issue in China [ 13 ]. During our 3-year study period, a total of 10,068 cases were reported, indicating that varicella was highly prevalent in Jinan.…”

Section: Discussionmentioning

confidence: 99%

“…According to notifiable infectious disease regulation, all varicella cases are reported to JNCDC through NNDRS using a standard pro forma that includes details of name, sex, age, address, and date of symptom onset. The diagnostic criteria for varicella cases are provided in a guidebook published by the Chinese Ministry of Health [ 13 ]. The case definition includes (1) fever and characteristic rash, and/or (2) a four-fold rise in antibody titre, or antigen detected in blood, or genetic material detected by polymerase chain reaction.…”

Section: Methodsmentioning

confidence: 99%

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Association between the incidence of varicella and meteorological conditions in Jinan, Eastern China, 2012–2014

et al. 2016

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BackgroundVaricella remains an important public health issue in China. In this study we explored the effect of weather conditions on the incidence of varicella in the temperate city of Jinan, Eastern China during 2012–2014 to inform public health prevention and control measures.MethodsData on reported cases of varicella were obtained from National Notifiable Disease Report System. Meteorological data for the same time period were obtained from the Jinan Meteorological Bureau. A negative binomial regression model was used to assess the relationships between meteorological variables and the incidence of varicella. Given collinearity between average temperature and atmospheric pressure, separate models were constructed: one including average temperature without atmospheric pressure, the other including atmospheric pressure but without average temperature. Both models included relative humidity, wind velocity, rainfall, sunshine, and year as independent variables.ResultsAnnual incidence rates of varicella were 44.47, 53.69, and 46.81 per 100,000 for 2012, 2013, and 2014, respectively. Each increase of 100 Pa (hPa) in atmospheric pressure was estimated to be associated with an increase in weekly incidence of 3.35 % (95 % CI = 2.94–3.67 %), while a 1 °C rise in temperature was associated with a decrease of 3.44 % (95 % CI = −3.73–3.15 %) in the weekly incidence of varicella. Similarly, a 1 % rise in relative humidity corresponded to a decrease of 0.50 % or 1.00 %, a 1 h rise in sunshine corresponded to an increase of 1.10 % or 0.50 %, and a 1 mm rise in rainfall corresponded to an increase of 0.20 % or 0.30 %, in the weekly incidence of varicella cases, depending on the variable considered in the model.ConclusionOur findings show that weather factors have a significant influence on the incidence of varicella. Meteorological conditions should be considered as important predictors of varicella incidence in Jinan, Eastern China.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association between the incidence of varicella and meteorological conditions in Jinan, Eastern China, 2012–2014

et al. 2016

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“…The post-exposure use of VarV was first suggested in the USA in 1999 (Galil et al, 1999). In China, a varicella emergency vaccination program was started in Beijing in 2006, in Guangzhou in 2012, and in Shanghai in 2013 (Li, 2013;Ma et al, 2009). However, the estimated effectiveness of post-exposure prophylaxis (PEP) in preventing any varicella has varied from 9% to 100% (Arbeter et al, 1986;Asano et al, 1977;Mor et al, 2004;Ma et al, 2009;World Health Organization, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of varicella vaccine as post-exposure prophylaxis during a varicella outbreak in Shanghai, China

Wu¹,

Liu²,

Xian

et al. 2018

International Journal of Infectious Diseases

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“…Several studies have shown that the VE of VarV as PEP during school outbreaks is significant (47.0-85.3%) (Cao et al, 2018;Ma et al, 2009;Wu et al, 2019;Wu et al, 2018). In addition, the incidence of varicella fell by 30.2% after the implementation of VarV as PEP in Guangzhou, China, in 2012 (Li, 2013). Therefore, the administration of VarV as PEP is an appropriate intervention for varicella outbreak control in countries where a two-dose VarV schedule has not yet been adopted.…”

Section: Discussionmentioning

confidence: 99%

“…However, in some cities with high economic productivity in China, such as Beijing and Shanghai, school outbreaks continue to occur despite high VarV coverage (Fu et al, 2015;Lu et al, 2012;Suo et al, 2017;Zhu et al, 2017). To contain varicella outbreaks, the administration of VarV has been recommended as a post-exposure prophylaxis (PEP) strategy in Chinese metropolitan cities, including Beijing (2006), Guangzhou (2012), and Shanghai (2013) (Cao et al, 2018;Li, 2013;Ma et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Varicella outbreak trends in school settings during the voluntary single-dose vaccine era from 2006 to 2017 in Shanghai, China

Xian

Liu

et al. 2019

International Journal of Infectious Diseases

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To investigate varicella outbreak trends among schoolchildren during the voluntary singledose varicella vaccine (VarV) era in Shanghai, China. Methods: Trends in school varicella outbreaks from 2006 to 2017 were assessed using joinpoint regression models. The impacts of changes in single-dose VarV coverage among schoolchildren and implementation of post-exposure prophylaxis (PEP) strategies on outbreak trends were further analyzed. Results: In total, 265 varicella outbreaks involving 3263 cases were reported in Shanghai from 2006 to 2017. The number of outbreaks showed an increasing trend from 2006 to 2017 (t = 2.62, p = 0.026), especially in kindergartens. The proportion of breakthrough varicella cases among all outbreak-related cases showed an increasing trend from 30.4% in 2008 to 85.7% in 2017 (t = 7.45, p < 0.001). Single-dose VarV coverage among schoolchildren was 88.1%, and showed a significant increase from the 1996 to the 2008 birth cohorts, followed by a non-significant decline from the 2008 to the 2014 birth cohorts. During school outbreaks in which PEP campaigns were conducted, the varicella attack rate was significantly lower than those in outbreaks without PEP campaigns (1.2% vs. 1.4%; Chi-square = 23.35, p < 0.001). Conclusions: Even with high coverage, single-dose VarV is insufficient to prevent school outbreaks. The administration of VarV as PEP is an appropriate intervention for varicella outbreak control prior to implementing a two-dose VarV schedule.

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Varicella emergency vaccination seemed instrumental in declining chickenpox incidente in Guangzhou, Southern China

Cited by 8 publications

References 7 publications

Association between the incidence of varicella and meteorological conditions in Jinan, Eastern China, 2012–2014

Association between the incidence of varicella and meteorological conditions in Jinan, Eastern China, 2012–2014

Effectiveness of varicella vaccine as post-exposure prophylaxis during a varicella outbreak in Shanghai, China

Varicella outbreak trends in school settings during the voluntary single-dose vaccine era from 2006 to 2017 in Shanghai, China

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