The close relationship between toxoplasmosis and kidney function

Kapoor, Shailendra

doi:10.1590/s0036-46652012000600011

Cited by 3 publications

(2 citation statements)

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“…In the past 10 years, many associations between latent toxoplasmosis and certain health disorders have been observed and published. Infected subjects have a highly increased probability of being diagnosed with schizophrenia (Torrey et al 2007, 2012), mood disorders (Pearce et al 2012; Radford et al 2012), epilepsy (Stommel et al 2001; Palmer, 2007), autism (Prandota, 2010; Blomstrom et al 2012), migraine and other headaches (Koseoglu et al 2009; Prandota, 2009), melanoma (Nagineni et al 2002), carcinoma of female genitals and breast cancer (Sanchis-Belenguer et al 1984; Vos, 1987), heart diseases (Paspalaki et al 2001; Yazar et al 2006), inflammatory bowel disease (Prandota, 2012), celiac disease (Nejad et al 2011; Prandota, 2012) impaired liver functions (Vethanyagam & Bryceson, 1976; Ustun et al 2004), hematological changes (Flegr & Stříž, 2011), thyroid diseases (Singh et al 1994; Kankova et al 2014), rheumatoid arthritis (Tomairek et al 1982; Torrey & Yolken, 2001; Shapira et al 2012), glomerulonephritis (van Velthuysen & Florquin, 2000; Kapoor, 2012; Toporovski et al 2012), diabetes (Kaňková et al 2015 b ), and changes in lipid contents, including atherosclerosis (Coppens, 2006; Flegr et al 2012). Infected subjects also have a higher probability of suicides (Yagmur et al 2010; Ling et al 2011; Pedersen et al 2012) and traffic or working place accidents (Alvarado-Esquivel et al 2012; Flegr et al 2002, 2009).…”

Section: Introductionmentioning

confidence: 99%

Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects – an explorative cross-sectional study

Flegr

Escudero

2016

Parasitology

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The global seroprevalence of latent toxoplasmosis is estimated to be higher than 30%. The presence of slowly dividing parasites in tissue cysts located mainly in immunoprivileged organs was long considered asymptomatic. Recently, many studies have shown that latent Toxoplasma infections could have serious impacts on human health. Here we ran a cross-sectional study in a population of 1486 volunteers. The results showed that 333 infected subjects scored worse than 1153 controls in 28 of 29 health-related variables. Similarly, they reported higher rates of 77 of a list of 134 disorders reported by at least 10 participants of the study. Toxoplasmosis was associated most strongly with musculoskeletal (τ = 0·107, P < 0·0005), followed by neurological (τ = 0·088, P < 0·0005), immune (τ = 0·085, p < 0·0005), metabolic (τ = 0·079, P < 0·0005), respiratory (τ = 0·068, P = 0·0001), allergic (τ = 0·053, P = 0·004), digestive system (τ = 0·052, P = 0·004) and mental health disorders (τ = 0·050, P = 0·008). Results of the present cohort study, along with the previous data from many case-control studies or ecological studies suggest that latent toxoplasmosis represents a large and so far underrated public health problem.

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Section: Introductionmentioning

confidence: 99%

Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects – an explorative cross-sectional study

Flegr

Escudero

2016

Parasitology

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“…However, toxoplasmosis secondary to renal transplantation is associated with significant morbidity. The median time to diagnosis of toxoplasmosis following renal transplantation is about 92 days, and the mortality rate is between 14% and 50% [118,119].…”

Section: Toxoplasma Gondiimentioning

confidence: 99%

Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections

Kot

Łanocha-Arendarczyk

Ptak

et al. 2021

IJMS

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Leishmaniasis, malaria, toxoplasmosis, and acanthamoebiasis are protozoan parasitic infections. They remain important contributors to the development of kidney disease, which is associated with increased patients’ morbidity and mortality. Kidney injury mechanisms are not fully understood in protozoan parasitic diseases, bringing major difficulties to specific therapeutic interventions. The aim of this review is to present the biochemical and molecular mechanisms in kidneys infected with Leishmania spp., Plasmodium spp., Toxoplasma gondii, and Acanthamoeba spp. We present available mechanisms of an immune response, oxidative stress, apoptosis process, hypoxia, biomarkers of renal injury in the serum or urine, and the histopathological changes of kidneys infected with the selected parasites. Pathomechanisms of Leishmania spp. and Plasmodium spp. infections have been deeply investigated, while Toxoplasma gondii and Acanthamoeba spp. infections in the kidneys are not well known yet. Deeper knowledge of kidney involvement in leishmaniasis and malaria by presenting their mechanisms provides insight into how to create novel and effective treatments. Additionally, the presented work shows gaps in the pathophysiology of renal toxoplasmosis and acanthamoebiasis, which need further research.

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Toxoplasmosis

2016

Diagnostic Pathology: Kidney Diseases

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The close relationship between toxoplasmosis and kidney function

Abstract: Dear SirThe recent article by TOPOROVSKY et al. was highly interesting 9 . The association of toxoplasmosis and renal function extends beyond nephrotic syndrome.

Cited by 3 publications

References 4 publications

Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects – an explorative cross-sectional study

Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects – an explorative cross-sectional study

Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections

Toxoplasmosis

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