Syndromic surveillance: etiologic study of acute febrile illness in dengue suspicious cases with negative serology. Brazil, Federal District, 2008

Abstract

SUMMARYWith the aim of identifying the etiology of acute febrile illness in patients suspected of having dengue, yet with non reagent serum, a descriptive study was conducted with 144 people using secondary serum samples collected during convalescence. The study was conducted between January and May of 2008. All the exams were re-tested for dengue, which was confirmed in 11.8% (n = 17); the samples that remained negative for dengue (n = 127) were tested for rubella, with 3.9% (n = 5) positive results. Among those non reactive for rubella (n = 122), tests were made for leptospirosis and hantavirus. Positive tests for leptospirosis were 13.9% (n = 17) and none for hantavirus. Non reactive results (70.8%) were considered as Indefinite Febrile Illness (IFI). Low schooling was statistically associated with dengue, rubella and leptospirosis (p = 0.009), dyspnea was statistically associated with dengue and leptospirosis (p = 0.012), and exanthem/petechia with dengue and rubella (p = 0.001). Among those with leptospirosis, activities in empty or vacant lots showed statistical association with the disease (p = 0.013). Syndromic surveillance was shown to be an important tool in the etiologic identification of IFI in the Federal District of Brazil.

La evidencia serológica de leptospirosis en pacientes con sospecha clínica de dengue en el estado de Ceará, Brasil

“…However, Behera, et al, considered a patient who was positive for the ELISA to be a case of co-infection, showing anti-dengue and antiLeptospira antibodies (27). Thirty-five patients remained without a specific laboratory diagnosis, suggesting that they had been infected by other (28)(29)(30).…”

Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil

“…Studies conducted to clarify doubts in the diagnosis of febrile disease of unknown etiology point to the need for immediate laboratory confirmation during outbreak/epidemic situations, as the many clinical manifestations may not characterize the diseases [48,49]. Serologic evidence of hantavirus has been identified in patients with clinical suspicion of dengue, malaria, influenza, chikungunya, rickettsial infections, leptospirosis, and HIV [50,51,52,53,54,55,56,57,58,59]. Thus, the results of this study in which the initial diagnosis was malaria and dengue, reinforce the need for an alert to health professionals working in endemic areas of malaria regarding the importance to investigate the hantavirus infection, as here performed with the population from Colniza.…”

Sistema de vigilancia epidemiológica para el síndrome febril agudo en Villeta, Colombia

“…El caso de Villeta se propone al ser una región endémica para varias etiologías con un cuadro clínico similar, sin embargo, es necesario realizar un abordaje oportuno e integral de estas enfermedades. Por ejemplo, en Brasil la vigilancia sindrómica permitió identificar etiologías asociadas con el síndrome febril agudo a partir de pacientes sospechosos de dengue, pero que no presentaban reactividad en las pruebas serológicas (35).…”