Evaluation of Helicobacter pylory colonization by serologic test (IgG) and dyspepsia in volunteers from the countryside of Monte Negro, in the Brazilian western Amazon region

Abstract

SUMMARYThe present study intended to analyze the seroprevalence of Helicobacter pylori, IgG, and its relation to dyspepsia in a population from the western Amazon region. During the "Projeto Bandeira Científica", a University of São Paulo Medical School program, in Monte Negro's rural areas, state of Rondônia, 266 blood samples were collected from volunteers. The material was tested for IgG antibodies anti-Helicobacter pylori by ELISA method and the participants were also interviewed on dyspepsia, hygiene and social aspects. Participants aged between five and 81 years old (34 years on average), 149 (56%) were female and 117 (44%) male. We found 210 (78.9%) positive, 50 (18.8%) negative and six (2.3%) undetermined samples. Dyspeptic complaints were found in 226 cases (85.2%). There was no statistical association between dyspepsia and positive serology for H. pylori. We concluded that the seroprevalence in all age categories is similar to results found in other studies conducted in developing countries, including those from Brazil. On the other hand, the seroprevalence found in Monte Negro was higher than that reported in developed countries. As expected, there was a progressive increase in the positivity for H. pylori in older age groups.

Prevalence of <i>Helicobacter pylori vacA</i>, <i>cagA</i>, <i>dupA</i> and <i>oipA</i> Genotypes in Patients with Gastric Disease

“…Studies have found that in Western countries, strains containing the s1m1 genotype are associated with a higher risk of gastric disease, as well as with enhanced proinflammatory response [17]. Similar to our results, Asrat, et al [18] and Suzuki, et al [19] also found s1m1 to be the most common vacA genotype.…”

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

“…in Rondônia, Brazil, in a sample of participants aged 11-20 years, evaluated in 2010 [24], and 82% in Iran, in subjects aged below 15 years, evaluated in 2006 [25]. In Portugal, the first national study addressing H. pylori prevalence (assessed by serology), published in 1994, showed that the prevalence of infection among children aged between 3 and 14 years was 46.2% [26].…”

Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study

“…This study reports that Mexican Americans and non‐Hispanic Blacks (52%) had a significantly higher seroprevalence of H. pylori when compared to non‐Hispanic Whites even after adjusting for country of origin (not US born vs US born) and socioeconomic status 9. In Central and South America, H. pylori seroprevalence, as determined by ELISA, has been reported to range from 50.7% to 84.7% depending on the region 12, 26, 27, 28. The observation that the seroprevalence detected among Hispanics living in Puerto Rico is more similar to estimates in general population from the US, rather than estimates from other Latin American countries, may be attributed to the US (and Puerto Rico as a US territory) having more developed living conditions compared to less developed regions in Latin America that have high H. pylori seropositivity, such as Honduras and Nicaragua 29.…”