Disseminated toxoplasmosis in an immunocompetent patient from Peruvian Amazon

Nunura, Juan; Vásquez, Tania; Endo, Sergio; Salazar, Daniela; Rodriguez, Alejandrina; Pereyra, Sonia; Solís, Hilda

doi:10.1590/s0036-46652010000200008

Cited by 27 publications

(16 citation statements)

References 35 publications

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“…Infections with T. gondii may result in an asymptomatic state or lead to disease. The parasite disseminates within the host's body and may affect lymph nodes, eyes, central nervous system, and other tissues [3,5-9]. In addition, primary infection during pregnancy may lead to severe damage to the fetus [2,3].…”

Section: Resultsmentioning

confidence: 99%

Toxoplasma gondii infection and abdominal hernia: evidence of a new association

Alvarado‐Esquivel¹,

Estrada-Martínez

2011

Parasites Vectors

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BackgroundWe performed a retrospective, observational study in 1156 adult subjects from the general population of Durango City, Mexico, Fifty five subjects with a history of abdominal hernia repair and 1101 subjects without hernia were examined with enzyme-linked immunoassays for the presence of anti-Toxoplasma IgG and IgM antibodies.ResultsThe seroprevalence of anti-Toxoplasma IgG antibodies and IgG titers was significantly higher in subjects with abdominal hernia repair than those without hernia. There was a tendency for subjects with hernia repair to have a higher seroprevalence of anti-Toxoplasma IgM antibodies than subjects without hernia. The seroprevalence of anti-Toxoplasma IgG antibodies in subjects with hernia repair was significantly higher in subjects ≥ 50 years old than those < 50 years old. Further analysis in subjects aged ≥ 50 years showed that the seroprevalence of anti-Toxoplasma IgG antibodies was also significantly higher in individuals with hernia repair than those without hernia (OR = 2.72; 95% CI: 1.10-6.57). Matching by age and sex further showed that the seroprevalence of Toxoplasma infection was significantly higher in patients with hernia repair than those without hernia (OR: 4.50; 95% CI: 1.22-17.33).ConclusionsResults indicate that infection with Toxoplasma is associated with abdominal hernia. The contributing role of infection with Toxoplasma in abdominal hernia was observed mainly in subjects aged ≥ 50 years old. Our results might have clinical, prevention and treatment implications and warrant for further investigation.

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Section: Resultsmentioning

confidence: 99%

Toxoplasma gondii infection and abdominal hernia: evidence of a new association

Alvarado‐Esquivel¹,

Estrada-Martínez

2011

Parasites Vectors

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“…The parasite can affect the host's lymph nodes, eyes, central nervous system, liver, and heart [3,5,6]. In liver, the parasite has been associated with a number of pathological changes including hepatomegaly, granuloma, hepatitis, and necrosis [7-14]. In addition, an epidemiological study has reported an association of T. gondii infection with liver cirrhosis [15].…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii infection and liver disease: a case-control study in a Northern Mexican population

et al. 2011

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BackgroundInfection with the protozoan parasite Toxoplasma gondii may cause liver disease. However, the impact of the infection in patients suffering from liver disease is unknown. Therefore, through a case-control study design, 75 adult liver disease patients attending a public hospital in Durango City, Mexico, and 150 controls from the general population of the same region matched by gender, age, and residence were examined with enzyme-linked immunoassays for the presence of anti-Toxoplasma IgG and anti-Toxoplasma IgM antibodies. Socio-demographic, clinical and behavioral characteristics from the study subjects were obtained.ResultsSeroprevalence of anti-Toxoplasma IgG antibodies and IgG titers did not differ significantly in patients (10/75; 13.3%) and controls (16/150; 10.7%). Two (2.7%) patients and 5 (3.3%) controls had anti-Toxoplasma IgM antibodies (P = 0.57). Seropositivity to Toxoplasma did not show any association with the diagnosis of liver disease. In contrast, seropositivity to Toxoplasma in patients was associated with consumption of venison and quail meat. Toxoplasma seropositivity was more frequent in patients with reflex impairment (27.8%) than in patients without this impairment (8.8%) (P = 0.05). Multivariate analysis showed that Toxoplasma seropositivity in patients was associated with consumption of sheep meat (OR = 8.69; 95% CI: 1.02-73.71; P = 0.04) and rabbit meat (OR = 4.61; 95% CI: 1.06-19.98; P = 0.04).ConclusionsSeropositivity to Toxoplasma was comparable among liver disease patients and controls. Further studies with larger sample sizes are needed to elucidate the association of Toxoplasma with liver disease. Consumption of venison, and rabbit, sheep, and quail meats may warrant further investigation.

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“…The organs most often involved are the lungs, heart, and brain, but any organ or system can eventually be involved. [9][10][11][12] In this case, our patient developed an atypical pneumonia, with cavities and pleural effusion. Biological findings revealed elevated concentrations of liver enzymes, glucose, and direct bilirubin, suggesting the patient had developed hepatitis.…”

Section: Discussionmentioning

confidence: 99%

Hemophagocytic Syndrome as Uncommon Presentation of Disseminated Toxoplasmosis in an Immunocompetent Adult from Chinese Kunming

Yang

Zuo²,

Hu³

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. Hemophagocytic syndrome is a rare disease that is often fatal, despite treatment. An immunocompetent patient was presented with fever, hepatosplenomegaly, cytopenias, hypertriglyceridemia, hypofibrinogenemia, and hyperferritinemia, which conformed to a hemophagocytic syndrome diagnosis. Despite broad antibiotic treatment, the patient's clinical condition rapidly deteriorated and he died within 8 days of admission. Blood cultures and a serology test were negative; however, based on morphological characteristics, tissue cysts Toxoplasma gondii were found in the bone marrow. Based on polymerase chain reaction analysis, identity of the parasite was confirmed. Although very rare, T. gondii-associated hemophagocytic syndrome should be suspected in the case of cytopenia or multiorgan failure symptoms. To our knowledge, this is the first fatal toxoplasmosis case reported from China.

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Disseminated toxoplasmosis in an immunocompetent patient from Peruvian Amazon

Cited by 27 publications

References 35 publications

Toxoplasma gondii infection and abdominal hernia: evidence of a new association

Toxoplasma gondii infection and abdominal hernia: evidence of a new association

Toxoplasma gondii infection and liver disease: a case-control study in a Northern Mexican population

Hemophagocytic Syndrome as Uncommon Presentation of Disseminated Toxoplasmosis in an Immunocompetent Adult from Chinese Kunming

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