Endomyocardial fibrosis: pathological findings in surgical specimens and clinicopathological correlation

Iglezias, Silvia D’Andretta

doi:10.1590/s0036-46652008000200015

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, this group did not provide an explanation for the phenomenon in the setting of human disease [17]. Such findings can correspond to a global marker of tissue injury, as well as a marker of collagen fiber space restructuring in the chordae restricted to this experimental model.…”

Section: Discussionmentioning

confidence: 72%

The use of a high-power laser on swine mitral valve chordae tendineae

et al. 2016

View full text Add to dashboard Cite

Worldwide, rheumatic fever remains a significant cause of mitral valve insufficiency. It is responsible for approximately 90 % of early childhood valvular surgeries in Brazil. Elongated or flail chordae are frequently responsible and require surgical correction. The purpose of this study was to analyze and compare the histological tissues of the mitral valve chordae and the mechanical resistance generated by the chordae, both with and without the application of a high-power laser. Twenty normal porcine mitral valve chordae were measured and divided randomly into the following two groups: control group (not subjected to a high-power laser) and laser group (subjected to photonic irradiation). Laser surgery was performed under controlled conditions, using following parameters: λ = 980-nm wavelength, power = 3 W, and energy = 60 J. A mechanical test machine was used in combination with a subsequent histological study to measure chordae tensile properties. A histological analysis demonstrated a typical collagen bundle arrangement in the control group; however, under a particular reached temperature range (48), the collagen bundles assumed different arrangements in the laser group. Significant reductions in the chordae tendineae lengths and changes in their resistance in the laser group were observed, as these chordae exhibited less rigid fibers. The chordae tendineae of normal porcine valves subjected to a high-power laser exhibited its length reduction and less stiffness compared to the control group. A histological analysis of the laser treatment specimens demonstrated differences in collagen bundle spatial organization, following slight changes into tissue temperature.

show abstract

Section: Discussionmentioning

confidence: 72%