Detection of Cysticercus antigens and antibodies in cerbrospinal fluid of patients with chronic meningitis

Parija, Subhash Chandra; Sahu, Priyadarshi Soumyaranjan; Dhanya, Hariharkrishnaiear

doi:10.1590/s0036-46652007000500011

Cited by 7 publications

(6 citation statements)

References 19 publications

(17 reference statements)

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“…solium larval stage antigen was detected by Co-A test in 57% of cysticercosis cases with hyperimmune sera raised to whole cyst antigen in the previous studies 20,21,22 . An interesting finding was that none of the HIV seropositive cases were positive for T. solium larval stage antigen.…”

Section: Discussionmentioning

confidence: 82%

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A serological study of cysticercosis in patients with HIV

Parija

Gireesh

2009

Rev. Inst. Med. trop. S. Paulo

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Neurocysticercosis (NCC) has attained the importance of one of the most common cause of focal brain lesions in patients infected with HIV (human immunodeficiency virus). Adequate data regarding the rate of this co-infection is lacking. Therefore, the present study was carried out to determine the prevalence of cysticercosis among HIV patients residing in Puducherry or its neighboring districts of Tamil Nadu State, India. A total of one hundred blood samples were collected from HIV seropositive cases visiting JIPMER hospital, Puducherry, between June 2007 and May 2008. Enzyme immunotransfer blot (EITB) and enzyme linked immunosorbent assay (ELISA) were used to demonstrate anti- T. solium larval stage antibodies and Co-agglutination (Co-A) test was used to detect T. solium larval stage antigens in sera. Two HIV seropositive cases were found positive for anti-T. solium larval stage antibody by EITB and four were positive by ELISA. Only one sample was positive by both EITB and ELISA. No serum sample was found positive for T. solium larval stage antigen by Co-A test. The overall seropositivity detected by all the methods was 5% in this study group. The accurate clinical diagnosis of NCC in HIV is difficult due to deranged immunological parameters in the HIV infected patients. The results of this study provides important data on the prevalence of cysticercosis in HIV positive patients in Puducherry and neighboring areas which was previously unknown. This study will also increase awareness among physicians and public health agencies about T. solium cysticercosis in the selected group.

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Section: Discussionmentioning

confidence: 82%

“…Thus, overall five samples were positive for anti-T. solium larval stage antibodies. The antigen detection limit of the Co-A test using the particular batch of reagent preparation was found to be up to 0.27 μg 21 .…”

Section: Co-agglutination Testmentioning

confidence: 96%

A serological study of cysticercosis in patients with HIV

Parija

Gireesh

2009

Rev. Inst. Med. trop. S. Paulo

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“…Subarachnoid cysts, however, can manifest as acute or chronic eosinophilic meningitis. 125,126 Here we focus on this more unusual presentation of neurocysticercosis, which may present with eosinophilia and eosinophilic meningitis.…”

Section: Gnathostomiasis E Gnathostoma Spinigerummentioning

confidence: 99%

Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management

Checkley

Chiodini

Dockrell

et al. 2010

Journal of Infection

102

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“…Human (neuro) cysticercosis, an infection caused by the metacestode larval stage of the pork tapeworm Taenia solium , is a serious but neglected zoonotic disease and a major public health problem in many developing countries of Latin America, Asia and Africa [1], [2]. Humans are the definitive hosts harbouring the adult tapeworm (leading to taeniosis).…”

Section: Introductionmentioning

confidence: 99%

The Incidence of Human Cysticercosis in a Rural Community of Eastern Zambia

et al. 2013

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A community-based longitudinal study was performed in the Eastern Province of Zambia, in which repeated serological samplings were done to determine the incidence of human cysticercosis. Three sampling rounds were carried out at six months intervals. A total of 867 participants presented for all three samplings. All samples were tested for the presence of cysticercus antigens using a monoclonal antibody-based enzyme-linked immunosorbent assay (sero-Ag-ELISA), while a randomly selected sub-sample of 161 samples from each sampling round was tested for specific antibodies using a commercial enzyme-linked immunoelectrotransfer blot (EITB) assay. Stool samples (n = 226) were also collected during the final round of sampling for taeniosis diagnosis by coprology and coproantigen ELISA. Cysticercosis seroprevalence varied from 12.2% to 14.5% (sero-Ag) and from 33.5% to 38.5% (sero-Ab) during the study period. A taeniosis prevalence of 11.9% was determined. Incidence rates of 6300 (sero-Ag, per 100000 persons-year) and 23600 (sero-Ab, per 100000 persons-year) were determined. Seroreversion rates of 44% for sero-Ag and 38.7% for sero-Ab were recorded over the whole period. In conclusion, this study has shown the dynamic nature of T. solium infections; many of the people at risk become (re)infected due to the high environmental contamination, with a high number turning seronegative within a year after infection. An important number of infections probably never fully establish, leading to transient antibody responses and short-term antigen presence.

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Detection of Cysticercus antigens and antibodies in cerbrospinal fluid of patients with chronic meningitis

Cited by 7 publications

References 19 publications

A serological study of cysticercosis in patients with HIV

A serological study of cysticercosis in patients with HIV

Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management

The Incidence of Human Cysticercosis in a Rural Community of Eastern Zambia

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