H antigen presence in an Ascaris lumbricoides extract

León, Patricia Ponce de; Foresto, Patricia; Valverde, Juana

doi:10.1590/s0036-46652005000300008

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Another studied invertebrate in respect to the presence of ABO histoblood group carbohydrates is the worm Ascaris lumbricoides. Extracts of this worm were able to neutralize anti-A, anti-B and anti-H monoclonal antibodies by inhibition agglutination tests [28][29][30]. These studies pointed out that the expression of H, A, and B histo-blood carbohydrates could be a strategy to mimicry host's tissue by modification of its cuticular surface as well as facilitate the escape of the host's immune response.…”

Section: Histo-blood Group-like Carbohydrates In Pathogenic Invermentioning

confidence: 99%

ABO, H, Lewis and Secretor histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates

Mattos¹,

Mattos²,

Miola³

2019

CMR

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ABO, H, Lewis, and Secretor histo-blood group systems express a repertoire of carbohydrate antigens in human hematopoietic and non-hematopoietic tissues. The oligosaccharide components of these systems are widely distributed in nature, including animal and plants. A set of reports demonstrated that pathogenic and non-pathogenic invertebrates are able to synthesize and or acquire histo-blood group-like carbohydrates from hosts. These abilities seem to be related to strategies for cell invasion as well as scape from host’s innate and adaptive immune responses. This text revised the literature and offers a tentative explanation for the presence of histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates and its importance in terms of evolution.

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Section: Histo-blood Group-like Carbohydrates In Pathogenic Invermentioning

confidence: 99%

ABO, H, Lewis and Secretor histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates

Mattos¹,

Mattos²,

Miola³

2019

CMR

View full text Add to dashboard Cite

show abstract

Genome-Wide Identification of Molecular Mimicry Candidates in Parasites

2011

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Among the many strategies employed by parasites for immune evasion and host manipulation, one of the most fascinating is molecular mimicry. With genome sequences available for host and parasite, mimicry of linear amino acid epitopes can be investigated by comparative genomics. Here we developed an in silico pipeline for genome-wide identification of molecular mimicry candidate proteins or epitopes. The predicted proteome of a given parasite was broken down into overlapping fragments, each of which was screened for close hits in the human proteome. Control searches were carried out against unrelated, free-living eukaryotes to eliminate the generally conserved proteins, and with randomized versions of the parasite proteins to get an estimate of statistical significance. This simple but computation-intensive approach yielded interesting candidates from human-pathogenic parasites. From Plasmodium falciparum, it returned a 14 amino acid motif in several of the PfEMP1 variants identical to part of the heparin-binding domain in the immunosuppressive serum protein vitronectin. And in Brugia malayi, fragments were detected that matched to periphilin-1, a protein of cell-cell junctions involved in barrier formation. All the results are publicly available by means of mimicDB, a searchable online database for molecular mimicry candidates from pathogens. To our knowledge, this is the first genome-wide survey for molecular mimicry proteins in parasites. The strategy can be adopted to any pair of host and pathogen, once appropriate negative control organisms are chosen. MimicDB provides a host of new starting points to gain insights into the molecular nature of host-pathogen interactions.

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H antigen presence in an Ascaris lumbricoides extract

Cited by 2 publications

References 5 publications

ABO, H, Lewis and Secretor histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates

ABO, H, Lewis and Secretor histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates

Genome-Wide Identification of Molecular Mimicry Candidates in Parasites

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