Prevalence of IgG varicella zoster virus antibodies in the Kuikuro and Kaiabi indigenous communities in Xingu National Park, Brazil, before varicella vaccination

Lafer, Manuel Mindlin; Moraes-Pinto, Maria Isabel de; Weckx, Lily Yin

doi:10.1590/s0036-46652005000300004

Cited by 10 publications

(9 citation statements)

References 17 publications

(18 reference statements)

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“…Among population-based studies of children and adults, in the absence of or before the introduction of routine varicella vaccination, the overall seroprevalence rate ranged between 58 and 99% in LAC: 58% in Puerto Rico [43], 78–80% in Bolivia [6, 7], 81% among Xingu indigenous ethnic groups in Brazil [27], 82% among Montevideo inhabitants in Uruguay [50], 86–99% in nationally representative samples in Mexico [39, 40], and 97.2–99.3% in different parts of Argentina [25].…”

Section: Resultsmentioning

confidence: 99%

“…The only factors consistently associated with seroprevalence rate were age and reported history of varicella infection [25, 27–29].…”

Section: Resultsmentioning

confidence: 99%

“…The seroprevalence data show that varicella in most of LAC is typically a disease of childhood rather than adolescence or adulthood and, in this regard, is generally closer to temperate countries before UVV programs were introduced. Seroprevalence rates in LAC consistently increase with age [6, 7, 25, 27, 29, 39, 40]. In a study in Mexico, for example, seroprevalence rates were 69% in children aged 5–9 years, rising to 94% in adults ≥ 20 years [39] (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

et al. 2019

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Background Varicella is typically mild and self-limiting, but can be associated with complications and even death. The limited data available on varicella in Latin America and the Caribbean (LAC) indicate substantial burden in countries where varicella vaccine is not part of publicly funded childhood national immunization programs. Methods A systematic literature review of published studies was complemented by “gray” literature on varicella incidence, complications, mortality, and economic consequences, in the absence and presence of universal varicella vaccination (UVV) in LAC. Results Seroprevalence data indicate that varicella is usually a disease of childhood in LAC. Varicella incidence rates, while unreliable in the absence of mandatory reporting, show a trend to increased incidence due to greater urbanization and population density. The introduction of UVV in national immunization programs has led to significant reductions in varicella incidence in these areas. Conclusions Varicella continues to pose a substantial healthcare burden in LAC. The future introduction of UVV in additional countries is predicted to provide substantial reductions in cases, with important economic benefits. For countries that have already implemented UVV, the challenge is to maintain high rates of coverage and, where relevant, consider inclusion of a second dose to reduce breakthrough cases. Given the significant proportion of the region now implementing UVV, a regional recommendation in order to prevent any potential for age-shifts in varicella infection might be considered. Electronic supplementary material The online version of this article (10.1186/s12889-019-6795-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

“…The only factors consistently associated with seroprevalence rate were age and reported history of varicella infection [25, 27–29].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

et al. 2019

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“…Indeed, a positive history of chickenpox better correlated with the presence of antibody than did a negative serologic test result for varicella [14,23,25]. In the populations of Brazil and Turkey, and the child population of Switzerland, the positive predictive value of the clinical history of varicella ranged from 95% to 100% [16,[31][32][33]. In the applicants for nurse training in Scotland, the positive predictive value of the history of varicella for seropositivity was 98%.…”

Section: Resultsmentioning

confidence: 99%

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Talebi-Taher

Noori²,

Shamshiri³

et al. 2010

International Journal of Occupational Medicine and Environmental Health

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Objectives: This study was designed to evaluate the immune status of health care workers against varicella zoster in a university hospital in Teheran, Iran, and to compare the history of chickenpox infection with the presence of varicella antibodies in this population. Methods: Serologic testing for varicella was performed for 405 health care workers with different job categories and at different age. The enzyme immunoassay was used for determining IgG antibodies against varicella zoster virus Results: A total of 405 health care workers, aged 19-50 years (median: 29 years), were examined. Of these, 289 (71.4%) were found to be seropositive. No statistically significant differences were observed between gender, age, or occupation, and seropositivity (p = 0.09, 0.75, 0.54. respectively). Statistical analysis revealed that the correlation between chickenpox history and seropositivity showed a 62.3% sensitivity, 72.4% specificity, 84.9% positive predictive value, and 43.5% negative predictive value. Conclusions: Serologic screening of health care workers is essential to determine their immunity to varicella, regardless of the age, occupation and history of infection. This population is recommended to be considered a target group for future immunization programs in Iran. Varicella is a common childhood disease. Nearly a 100% seropositivity to VZV has been documented in children between 11-13 years of age in the USA. An epidemiological variation is being reported between the temperate and tropical climate countries, with varicella occuring mainly among young adults in the tropical regions [2]. Key words: Health care workers, Varicella zoster infection, ImmunizationThe general adult seroprevalence rates amount to 81.3% in the United Arab Emirates, 100% in Belgium, 96.6% in Israel, 95% in Turkey, 95.5% in Spain, 50% in Sri Lanka,.Moreover, nosocomial transmission of VZV is also reported in health care workers (HCWs) [10]. It seems that A checklist was completed including demographic data and the history of varicella. Individuals with acute varicella infection, those under immunosuppressive therapy, or those having blood transfusion during the year 2008, were excluded from the study. The local ethics committee approved the study protocol, and a signed informed consent was obtained from each participant. Blood samples were collected from each individual and the separated serum was stored at -20°C prior to testing. EIA for varicella-specific IgG was performed using commercial virus-specific IgG EIA kits (varicella IgG EIA well, RADIM, Italy; sensitivity 100%, specificity 88%). Optical density values were indexed according to the manufacturer's instructions. Sera were classified as negative if the OD was less than 0.20 and as positive if it was higher than 0.70; sera with OD between 0.20 and 0.70 were considered equivocal. Equivocal values were considered negative. Statistical analysis was performed using the SPSS 13 software. After conducting descriptive statistical analyses, we used the chi square test to study t...

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“…This study was performed between June and September 2001 at the Xingu Indigenous National Park, a 2,642,003 hectare area, located in the North of the Mato Grosso State, with a population of 3,919 inhabitants, as described elsewhere 14 . The research protocol was submitted to and approved by the Ethics Committee of the Federal University of São Paulo (UNIFESP) and by the National Ethics Committee of the Brazilian Ministry of Health.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of antibodies against hepatitis A virus among the Kuikuro and Kaiabi Indians of Xingu National Park, Brazil

Lafer

Moraes-Pinto²,

Weckx³

2007

Rev. Inst. Med. trop. S. Paulo

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SUMMARYA seroprevalence study to detect total antibodies against Hepatitis A Virus was done with 220 samples from 589 Native Indians from Xingu National Park, Brazil, in five Kaiabi and Kuikuro villages, the most populous ethnic groups. Using a commercial immunoassay kit we detected 97.7% positive samples (95% Confidence Interval: 95%-99%). We noticed a precocious seroconversion, before the age of six years, when the disease is usually asymptomatic. These results are similar to those found in the literature in non-Indian population studies of the Northern, Northeastern and West Central regions of Brazil. They suggest that it is not necessary to introduce vaccination against Hepatitis A in these highly endemic populations.

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Prevalence of IgG varicella zoster virus antibodies in the Kuikuro and Kaiabi indigenous communities in Xingu National Park, Brazil, before varicella vaccination

Cited by 10 publications

References 17 publications

Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

Varicella Zoster antibodies among health care workers in a university hospital, Teheran, Iran

Prevalence of antibodies against hepatitis A virus among the Kuikuro and Kaiabi Indians of Xingu National Park, Brazil

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