Clinical laboratory assessment of hepatitis C and HIV coinfected patients according to the antiretroviral therapy received

Abstract

SUMMARYDuring the year of 2001, a retrospective, descriptive study in order to determine the influence of the antiretroviral therapy received by 111 HIV-HCV coinfected patients who had undergone at least one liver biopsy was conduced, 74 of them were treated with a protease inhibitor regimen (WPI), and 37 with a non-protease inhibitor regimen (NPI). The main characteristics found were: a young patient population (mean age 41 years old in both groups), composed in most part of male individuals (74.3% WPI and 51.4% NPI) with previous risk factors for both infections (WPI 93.2% and NPI 89.2%). The most significant findings included AIDS-defining disease (WPI 18.9% and NPI 13.5% of the cases), elevated hepatic enzyme levels (WPI: SGOT 52.1 and NPI 53.2), absence of liver disease-related symptoms (16.2% for both groups), average CD4 count > 350 for both groups (WPI 362.2 and NPI 378.1), predominantly low-grade fibrosis in both populations (0-2 in 63.6% of WPI patients and in 80% of NPI patients), with necro-inflammatory activity ranging from 5-7 in 51.3% and 42.9% of WPI patients and NPI patients, respectively. It is suggested a sequential biopsy to better evaluate the evolution of the hepatic disease, according to the HAART regimen received.

Alcohol misuse and illicit drug use are associated with HCV/HIV co-infection

“…Additional studies are needed to elucidate how this drug use potentiates other routes of transmission. On the other hand, low educational level was associated with the risk of HIV/HCV co-infection, similar to previous findings in other Brazilian populations [19,28]. Most patients included in this study had low educational levels, which is correlated to low socioeconomic situations, reduced hygiene standards, overcrowding and restricted health service access.…”

Avaliação do dano hepático em pacientes HIV positivo sob terapia antirretroviral no município de Carazinho/RS

“…Isso também foi evidenciado por Navarro et al 28 , considerando que a transfusão de sangue foi um fator de risco que quase desapareceu em consequência dos testes sorológicos.…”

Hepatoportal venopathy due to disseminated Mycobacterium avium complex infection in a child with IFN-γ receptor 2 deficiency

“…Veno-occlusive disease and hepatoportal venopathy have been described in patients with central and portal hepatic vein involvement due to storage diseases, sarcoidosis, primary biliary cirrhosis, primary sclerosing cholangitis, mastocytosis, cystinosis, schistosomiasis, and graft-vs-host disease [5,7,15]. Granulomatous disease associated with non-cirrhotic portal hypertension is rarely reported; primary biliary cirrhosis and sarcoidosis are the most frequent causes [12,16].…”