p53 immunostaining pattern in Brazilian patients with hepatocellular carcinoma

Alves, Venâncio Avancini Ferreira; Nita, Marcelo Eidi; Carrilho, Flair José; Ono‐Nita, Suzane Kioko; Wakamatsu, Alda; Lehrbach, Dárcio Matenhauer; Carvalho, Maria Fernanda Pimentel de; Mello, Evandro Sobroza de; Gayotto, Luiz Carlos da Costa; Silva, Luiz Caetano da

doi:10.1590/s0036-46652004000100005

Cited by 10 publications

(13 citation statements)

References 37 publications

(31 reference statements)

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“…From a total of 39 patients with cirrhosis, only 13 (33.3%) presented expression of the p53 protein [19], while in our study, a p53 protein altered expression appeared in 69 patients (91%). The nuclear p53 expression in moderate and high grade of tumour differentiation was detected in 6 out of 27 patients versus 7 out of 12 patients with low tumour differentiation [19]. The difference between the two groups was statistically significant (p=0.03).…”

Section: Discussioncontrasting

confidence: 68%

“…In the study by Alves et al [19], 54 Brazilian patients with HCC were included. Of these, 19 (35%) presented immunohistochemical p53 protein expression.…”

Section: Discussionmentioning

confidence: 99%

“…That is why by studying the relation between the presence of viral hepatitis B and C infection and alcohol consumption and (23) 3-5 cm, n (%) 0 (0) 5 (72) 1 (14) 1 (14) > 5 cm, n (%) 2 (6) 9 (27) 10 (29) 13 (38) Presence of cirrhosis, n (%) 1 (2) 10 (34) 9 (30) 10 (34) the genetic mutations, the researchers noted that there was no significant relation between these risk factors and the genetic mutations. The genetic mutations have been more frequently observed in patients in whom the hepatic tumours did not develop in a cirrhotic liver, as compared to patients who had the tumour developed in a cirrhotic liver [19]. Another study [20] reported an overexpression in 22 cases (31%) detected by immunohistochemistry of protein p53 with monoclonal antigen Pab1801.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of p53 Protein Expression in Hepatocellular Carcinoma

Graur

Furcea

Moiş

et al. 2016

JGLD

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Background & Aims: Hepatocellular carcinoma (HCC) has a growing incidence and studies regarding the risk factors or pathogenesis for this type of carcinoma benefit special interest. This study evaluates the correlations between p53 protein expression and clinical and laboratory factors in patients withHCC. Methods: The study group included 76 patients diagnosed with HCC, either by biopsy or after surgical resection (with curative intent). Immunohistochemistry for p53 protein assessment was performed in all patients. Correlations between the protein 53 expression and age, tumour size, viral infection, liver cirrhosis were performed using the chi-square test (Pearson‘s chi-square) together with the contingency coefficient Kendall‘s coefficient in the tau-b form. Results: In the study group, 51 patients were male (67%) and 25 female (33%). Cirrhosis due to hepatitis virus B or C infection (in a proportion of 63% of the study group) was not significantly associated with the presence of HCC. Altered expression of p53 protein was observed in 69 patients (91%). The relationship between p53 protein expression and patient sex (p=0.067), age (p=0.531), tumour size (p=0.270), presence of hepatitis B and C viral infections (p=0.7), and of liver cirrhosis (p=0.511) was not statistically significant. Conclusion: The p53 protein expression was not significantly associated with the demographic characteristics of the patients, tumour size, presence of viral B and C infections or liver cirrhosis. Abbreviations: HBV: hepatitis B virus; HCV: hepatitis C virus; HCC: hepatocellular carcinoma; TP53: tumour protein p53; MDR: multi-drug resistance gene.

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Section: Discussioncontrasting

confidence: 68%

“…In the study by Alves et al [19], 54 Brazilian patients with HCC were included. Of these, 19 (35%) presented immunohistochemical p53 protein expression.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of p53 Protein Expression in Hepatocellular Carcinoma

Graur

Furcea

Moiş

et al. 2016

JGLD

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“…Pelo fato de a incidência ser muito variável segundo as diferentes áreas geográficas, o Hepatocarcinoma tem sido instrumento de identificação de muitos fatores de risco (Alves et al, 2004). Atenção especial deve ser dada à ingestão de grãos e cereais que quando armazenados em locais inadequados e úmidos, podem ser contaminados pelo fungo Aspergillus flavus.…”

Section: Epidemiologia E Fatores Etiológicosunclassified

“…Por outro lado, células com mutações ou outro tipo de inativação do gene p53 (TP53), não têm o ciclo celular bloqueado e continuam a se dividir, perpetuando a mutação nas futuras células filhas (Vogelstein et al, 1992;Alberts et al, 2002). A inativação do gene p53 pode decorrer de uma série de alterações, como deleções cromossômicas, mutações frameshit ou missense, entre outras, sendo descritas em vários tipos de câncer, como cólon, cérebro, pulmão, fígado, bexiga e estômago (Vogelstein et al, 1992;Tolbert et al, 1999;Alves et al, 2004;Soussi et al, 2006).…”

Section: I4 a Proteína P53unclassified