The venomous toadfish Thalassophryne nattereri (niquim or miquim): report of 43 injuries provoked in fishermen of Salinópolis (Pará State) and Aracaju (Sergipe State), Brazil

Haddad, Vidal; Pardal, Pedro Pereira de Oliveira; Cardoso, João Luiz Costa; Martins, Itamar Alves

doi:10.1590/s0036-46652003000400009

Cited by 44 publications

(15 citation statements)

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“…Thalassophryne nattereri is the most common species of Batrachoididae family in the region studied [13]. Envenomation by this fish is frequent in the northern and northeastern regions of Brazil [13].…”

Section: Venomous Fishesmentioning

confidence: 90%

“…Envenomation by this fish is frequent in the northern and northeastern regions of Brazil [13]. This family has the most complete venom inoculating apparatus, which is formed by four canaliculated spines (two lateral and two dorsal) located in a preoperculum position and anterior to the dorsal fins, all of which are directly linked to venom glands [13,14]. The stingers function like needles.…”

Section: Venomous Fishesmentioning

confidence: 99%

“…The stingers function like needles. Upon penetrating the tissue of the victim, the integumentary sheath ruptures, pushing the venom into the duct and injecting it into the victim [13,15]. In Brazil, theses fishes are small to medium sized (approximately 15 cm) and are numerous in estuarine areas in the northern and northeastern regions of the country [13].…”

Section: Venomous Fishesmentioning

confidence: 99%

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Potentially dangerous fish of the Paraiba Estuary: Identification and envenomation mechanisms

Macêdo¹,

Silva²,

Oliveira³

et al. 2017

JCLM

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Section: Venomous Fishesmentioning

confidence: 90%

Section: Venomous Fishesmentioning

confidence: 99%

Section: Venomous Fishesmentioning

confidence: 99%

See 1 more Smart Citation

Potentially dangerous fish of the Paraiba Estuary: Identification and envenomation mechanisms

Macêdo¹,

Silva²,

Oliveira³

et al. 2017

JCLM

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“…Acidentes provocados pelo T. nattereri vêm sendo notificados em Salvador (ALMEIDA et al, 1989), , 1992;FONSECA et al, 2000), Natal e Pará (HADDAD JR et al, 2003) e Fortaleza (FACÓ et al, 2005 (BAGGIOLINI et al, 1998;ULBRICH et al, 2003). de proliferação e diferenciação em célula efetora Th1 ou Th2.…”

Section: Introductionunclassified

“…Acidentes provocados pelo T. nattereri vêm sendo notificados em Salvador (ALMEIDA et al, 1989), Alagoas (AUTO, 1992;FONSECA et al, 2000), Natal e Pará (HADDAD JR et al, 2003) e Fortaleza (FACÓ et al, 2005). Estes acidentes ocorrem principalmente nas regiões plantar ou palmar das vítimas após a introdução dos espinhos canaliculados na pele com conseqüente ruptura das glândulas.…”

Section: Introductionunclassified

Avaliação do papel da nattectina, toxina do veneno de Thalassophryne nattereri, na respota imune inata e específica.

Saraiva¹

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RESUMOO objetivo deste trabalho foi avaliar a resposta imune inata induzida pela Nattectina, uma lectina tipo C isolada do veneno de Thalassophryne nattereri, em um modelo de inflamação murina e subseqüentemente seu papel na ativação das células dendríticas e indução da resposta imune específica. Nossos resultados mostram que a Nattectina induziu uma reação inflamatória na cavidade peritoneal de camundongos BALB/c caracterizada pelo influxo predominante de neutrófilos em 1 e 6 horas, substituído por macrófagos em 24 horas. Análises do sobrenadante da suspensão celular da cavidade peritoneal mostraram que a Nattectina induziu a liberação de mediadores inflamatórios como LTB 4 e PGE 2 em 6 horas, IL-1β em 1 e 6 h, IL-6 em 1 h, MCP-1 em 1 e 24 h e KC em 1 h. Além disso, IL-12p70 foi observada no peritônio em 1 e 24 h e IL-10 em 6 e 24 h. Células dendríticas imaturas de origem mieloíde (CD11b high CD11c high B220 low ) foram amadurecidas pela Nattectina com aumento na expressão das moléculas MHC de classe II e das coestimulatórias CD40, CD80 e CD86 e expressão de metaloproteinases de matriz MMP-2 e MMP-9, com síntese de IL-10 e IL-12p70. As células dendríticas imaturas apresentaram grande capacidade de captura e apresentação da Nattectina. Como conseqüência da ativação das células dendríticas, a Nattectina foi capaz de desencadear uma reposta imune adaptativa caracterizada pela ativação preferencial de linfócitos Th1, com síntese de IFN-γe de IL-10, favorecendo a produção de IgG2a específica. A presença de IL-10 pode ser responsável pela limitação da inflamação patológica induzida pelo veneno de T. nattereri e pela manutenção da inflamação crônica não resolvida observada no envenenamento. Finalmente, a Nattectina é um potente candidato antigênico juntamente com as células dendríticas para uso em imunoterapias.PDF Creator: PDF4U Pro DEMO Version. If you want to remove this line, please purchase the full version ABSTRACTRecently, it was identified a C-type lectin in the venom of Thalassophryne nattereri fish named Nattectin. In this study, we investigated the innate and adquired immune responses induced by Nattectin and consequently its role in the dendritic cell activation. The toxin was i.p. injected in BALB/c mice for evaluation of cellular recruitment and inflammatory mediators, antibody and cytokine production. Dendritic cells obtained after bone marrow cell culture with GM-CSF for 7d were stimulated with Nattectin for 24h. The expression of surface molecules and MMPs were analyzed by FACS and immunohistochemistry, respectively. Nattectin induced a significant cellular recruitment into peritoneal cavity, mainly neutrophils at 1 and 6hfollowed by macrophages at 24h. One hour after the Nattectin injection the levels of IL-6, IL-1β, MCP-1 and KC were detected, however in 6 or 24h only IL-1β and IL-10 or MCP-1 and IL-12p70 were determined, respectively. Nattectin induced the PGE 2 and LTB 4 synthesis at 6h. After immunization, mice produced elevated levels of anti- immune response that might be related to its activit...

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Bony Fish (Class: Osteichthyes)

Barceloux

2008

Medical Toxicology of Natural Substances

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The Scorpaenidae family contains venomous species of the genera Pterois (lionfi sh), Scorpaena (scorpionfi sh, sculpin), and Synanceia (stonefi sh). This family consists of 70 genera and about 350 species; venomous species from the family Scorpaenidae are some of the most venomous bony fi sh species. Approximately 80 of the 350 species are venomous. Venomous species of this family include the South Australian cobbler or soldierfi sh ( Gymnapistes marmoratus Cuvier), lionfi sh ( Dendrochirus species), sculpin ( Scorpaena species), and fortescue ( Centropogon australis White). Classifi cation of these fi sh is based on the morphology of the venom apparatus. The bony plate that covers the facial region from the eyes to the gill helps identify this diverse family (i.e., " mail -cheeked " fi sh). Stonefi sh species ( Synanceia spp.) include the common or estuarine stonefi sh ( S. horrida L.), the reef stonefi sh ( S. verrucosa Bloch & Schneider), the dwarf stonefi sh ( Synanceia nana Eschmeyer & Rama -Rao), the Indian stonefi sh ( S. horrida L.), and the pitted stonefi sh ( Synanceia erosa Cuvier or Erosa erosa ). The bullrout ( Notesthes robusta G ü nther) is a venomous member of the Tetrarogidae family. Common Name: Lionfi sh, Zebrafi sh, Red Lionfi sh, Butterfl y Cod, Lion Fish, Ornate Butterfl y -Cod, Peacock Lionfi sh, Red Firefi sh, Scorpion Volitans, Turkey Fish, and Turkeyfi sh Scientifi c Name: Pterois spp. ( P. volitans L., P. radiata Cuvier, P. antennata Bloch) Physical Description: This group of colorful, graceful fi sh has fan -like fi ns. The length of this beautiful Asian tropical fi sh is about 30 -38 cm ( ∼ 12 -15 in.)with vertical, dark stripes and long slender dorsal and ventral spines. Although coloration is highly variable, these fi sh are frequently zebra -banded in red and white. There are numerous spiny projections and fl eshy tabs on the head. The eyes protrude dorsally over a large mouth that has numerous skin appendages. Figure 183.1 displays a specimen of the lionfi sh ( Pterois volitans L.).Common Name: Sculpin Scientifi c Name: Scorpaena guttata Girard Physical Description: The sculpin has a stocky, slightly compressed body with a large head, protruding eyes, and a large mouth and pectoral fi ns. The color is red to brown with dark patches over the body and fi ns. Most sculpins are small ( < 6 in./ < 15 cm), but the cabezon ( Scorpaenichthys marmoratus Ayres) reaches 39 in. ( ∼ 100 cm) in length.

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The venomous toadfish Thalassophryne nattereri (niquim or miquim): report of 43 injuries provoked in fishermen of Salinópolis (Pará State) and Aracaju (Sergipe State), Brazil

Cited by 44 publications

References 1 publication

Potentially dangerous fish of the Paraiba Estuary: Identification and envenomation mechanisms

Potentially dangerous fish of the Paraiba Estuary: Identification and envenomation mechanisms

Avaliação do papel da nattectina, toxina do veneno de Thalassophryne nattereri, na respota imune inata e específica.

Bony Fish (Class: Osteichthyes)

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