UNA virus: first report of human infection in Argentina

Díaz, Luis Adrián; Spinsanti, Lorena; Almirón, Walter Ricardo; Contigiani, Marta Silvia

doi:10.1590/s0036-46652003000200012

Cited by 15 publications

(11 citation statements)

References 6 publications

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“…16 To our knowledge, our results demonstrate the highest seroprevalence of UNAV reported in the literature as for July 2020. 14,28 Using catalytic FOI model fit to age-stratified seroprevalence data, we reconstructed 50 years of historical transmission rates for VEEV and MADV for seven locations in Darien Province. In most locations, the data indicated consistent endemic transmission of these viruses.…”

Section: Discussionmentioning

confidence: 99%

Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys

Carrera

Cucunubá

Neira

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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Madariaga virus (MADV) has recently been associated with severe human disease in Panama, where the closely related Venezuelan equine encephalitis virus (VEEV) also circulates. In June 2017, a fatal MADV infection was confirmed in a community of Darien Province. We conducted a cross-sectional outbreak investigation with human and mosquito collections in July 2017, where sera were tested for alphavirus antibodies and viral RNA. In addition, by applying a catalytic, force-of-infection (FOI) statistical model to two serosurveys from Darien Province in 2012 and 2017, we investigated whether endemic or epidemic alphavirus transmission occurred historically. In 2017, MADV and VEEV IgM seroprevalences were 1.6% and 4.4%, respectively; IgG antibody prevalences were MADV: 13.2%, VEEV: 16.8%, Una virus (UNAV): 16.0%, and Mayaro virus: 1.1%. Active viral circulation was not detected. Evidence of MADV and UNAV infection was found near households, raising questions about its vectors and enzootic transmission cycles. Insomnia was associated with MADV and VEEV infections, depression symptoms were associated with MADV, and dizziness with VEEV and UNAV. Force-of-infection analyses suggest endemic alphavirus transmission historically, with recent increased human exposure to MADV and VEEV in Aruza and Mercadeo, respectively. The lack of additional neurological cases suggests that severe MADV and VEEV infections occur only rarely. Our results indicate that over the past five decades, alphavirus infections have occurred at low levels in eastern Panama, but that MADV and VEEV infections have recently increased-potentially during the past decade. Endemic infections and outbreaks of MADV and VEEV appear to differ spatially in some locations of eastern Panama.

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Section: Discussionmentioning

confidence: 99%

Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys

Carrera

Cucunubá

Neira

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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“…albipes, [22][23][24] but there is no indication that these are the predominant species involved in virus maintenance or epidemic transmission. Serosurveys have identified antibodies against UNAV in birds, horses, and humans [25][26][27][28] ; however, the extent of viral distribution and human disease risk is unknown.…”

Section: Introductionmentioning

confidence: 99%

Genetic Relationships Among Mayaro and Una Viruses Suggest Distinct Patterns of Transmission

Powers¹,

Aguilar

Chandler

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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Mayaro and Una viruses (MAYV, UNAV) are mosquito-borne alphaviruses that may cause an acute febrile illness characterized by headache, retro-orbital pain, and rash that may progress to a severe and prolonged arthralgia. MAYV was first isolated in Trinidad in 1954, and UNAV was first identified in northern Brazil in 1959. Since then, numerous isolates of these agents have been made from humans, wild vertebrates, and mosquitoes in several countries in northern South America. Serological evidence suggests that these viruses are also present in portions of Central America. Because little is known about the natural transmission cycle of MAYV and virtually nothing is known about UNAV transmission, 63 isolates covering the known geographic and temporal ranges were used in phylogenetic analyses to aid in understanding the molecular epidemiology. Approximately 2 kb from the E1 and E2 glycoprotein genes and the complete 3' non-coding region were sequenced. Phylogenetic analyses of these sequences indicated that two distinct genotypes of MAYV exist with a distinct clade consisting exclusively of UNAV (previously designated as a subtype of MAYV). One MAYV genotype (genotype D) contains isolates from Trinidad and the northcentral portion of South America including Peru, French Guiana, Surinam, Brazil, and Bolivia. All of these isolates are highly conserved with a nucleotide divergence of < 6%. The second MAYV genotype (genotype L) contains isolates only from Brazil that are highly conserved (< 4% nucleotide divergence) but are quite distinct (15-19%) from the first genotype isolates. These analyses provide possible explanations for the natural ecology and transmission of MAYV and UNAV.

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“…The virus can infect humans; however, no known disease is associated with infection. 11 The arrival of CHIKV in the Americas may have consequences for transmission cycles for the two New World members of the SF complex. In this report, we assessed whether neutralizing antibodies from natural CHIKV infection could potentially cross-neutralize MAYV and UNAV.…”

mentioning

confidence: 99%

Neutralizing Antibodies from Convalescent Chikungunya Virus Patients Can Cross-Neutralize Mayaro and Una Viruses

Martins

Gregory

Valdez

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Most alphaviruses are mosquito-borne and can cause severe disease in domesticated animals and humans. The most notable recent outbreak in the Americas was the 2014 chikungunya virus (CHIKV) outbreak affecting millions and producing disease highlighted by rash and arthralgia. Chikungunya virus is a member of the Semliki Forest (SF) serocomplex, and before its arrival in the Americas, two other member of the SF complex, Una (UNAV) and Mayaro (MAYV) viruses, were circulating in Central and South America. This study examined whether antibodies from convalescent CHIKV patients could cross-neutralize UNAV and MAYV. Considerable cross-neutralization of both viruses was observed, suggesting that exposure to CHIKV can produce antibodies that may mitigate infection with UNAV or MAYV. Understanding the impact of CHIKV exposure on population susceptibility to other emerging viruses may help predict outbreaks; moreover, identification of cross-reactive immune responses among alphaviruses may lead to the development of vaccines targeting multiple viruses.

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UNA virus: first report of human infection in Argentina

Cited by 15 publications

References 6 publications

Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys

Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys

Genetic Relationships Among Mayaro and Una Viruses Suggest Distinct Patterns of Transmission

Neutralizing Antibodies from Convalescent Chikungunya Virus Patients Can Cross-Neutralize Mayaro and Una Viruses

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