ABO System: molecular mimicry of Ascaris lumbricoides

León, Patricia Ponce de; Valverde, Juana

doi:10.1590/s0036-46652003000200011

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…The difference of five dilutions between both titers has significantly confirmed the presence of H Antigen in the extract. The fact that the extract did not inhibit the agglutination against anti A, anti B and anti AB has corroborated previous observations about the absence of A and B epitopes in A. lumbricoides extracts from O Group patients 4,6 .…”

Section: Abstract: H Antigen; Ascaris Lumbricoidessupporting

confidence: 87%

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H antigen presence in an Ascaris lumbricoides extract

León

Foresto

Valverde

2005

Rev. Inst. Med. trop. S. Paulo

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SUMMARYPrevious experiences have demonstrated the same ABO system and P system antigens in A. lumbricoides extracts and in their hosts. The aim was to show the behavior of an A. lumbricoides extract from an O Group patient against monoclonal antibodies of different specificities. Agglutination Inhibition Tests were carried out facing the extract against monoclonal antibodies (anti A 2.23; anti B 2.54; anti B 2.62; anti AB 2.39 and anti H 2.72) in optimal concentrations. Suspensions of O Group fresh red cells were used as revealing system. The extract only inhibited the agglutination of anti H 2.72 with O erythrocytes. The semiquantitative Agglutination Inhibition Test of the extract was made against two series of anti H 2.72 dilutions by using O Group fresh red cells as revealing system. A difference of five dilutions between the titers of both series has been observed and the presence of H Antigen in the extract has been significantly confirmed. The fact that the extract did not inhibit the agglutination against anti A, anti B and anti AB has corroborated our previous observations about absence of A and B epitopes in A. lumbricoides extracts from O Group patients. The results of the preceding studies and this experience have demonstrated the membrane glycoconjugated importance in A. lumbricoides. They could be involved in molecular mimicry for this parasite.

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Section: Abstract: H Antigen; Ascaris Lumbricoidessupporting

confidence: 87%

“…Previous experiences have shown the same ABO System and P System antigens in Ascaris lumbricoides extracts and in their hosts 4,5,6,7 . The aim was to show the behavior of an A. lumbricoides extract from an O Group patient against monoclonal antibodies of different specificities.…”

Section: Abstract: H Antigen; Ascaris Lumbricoidesmentioning

confidence: 62%

H antigen presence in an Ascaris lumbricoides extract

León

Foresto

Valverde

2005

Rev. Inst. Med. trop. S. Paulo

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“…Ascaris lumbricoides was found to possess A- and B-like blood group antigens [19]. This was confirmed by more recent studies, which suggested that these antigens had been acquired from host blood [20]. Biosynthesis of human blood group-like antigens was described for Schistosoma mansoni [21], [22] and Fasciola hepatica [23].…”

Section: Introductionmentioning

confidence: 59%

Genome-Wide Identification of Molecular Mimicry Candidates in Parasites

2011

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Among the many strategies employed by parasites for immune evasion and host manipulation, one of the most fascinating is molecular mimicry. With genome sequences available for host and parasite, mimicry of linear amino acid epitopes can be investigated by comparative genomics. Here we developed an in silico pipeline for genome-wide identification of molecular mimicry candidate proteins or epitopes. The predicted proteome of a given parasite was broken down into overlapping fragments, each of which was screened for close hits in the human proteome. Control searches were carried out against unrelated, free-living eukaryotes to eliminate the generally conserved proteins, and with randomized versions of the parasite proteins to get an estimate of statistical significance. This simple but computation-intensive approach yielded interesting candidates from human-pathogenic parasites. From Plasmodium falciparum, it returned a 14 amino acid motif in several of the PfEMP1 variants identical to part of the heparin-binding domain in the immunosuppressive serum protein vitronectin. And in Brugia malayi, fragments were detected that matched to periphilin-1, a protein of cell-cell junctions involved in barrier formation. All the results are publicly available by means of mimicDB, a searchable online database for molecular mimicry candidates from pathogens. To our knowledge, this is the first genome-wide survey for molecular mimicry proteins in parasites. The strategy can be adopted to any pair of host and pathogen, once appropriate negative control organisms are chosen. MimicDB provides a host of new starting points to gain insights into the molecular nature of host-pathogen interactions.

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“…Another studied invertebrate in respect to the presence of ABO histoblood group carbohydrates is the worm Ascaris lumbricoides. Extracts of this worm were able to neutralize anti-A, anti-B and anti-H monoclonal antibodies by inhibition agglutination tests [28][29][30]. These studies pointed out that the expression of H, A, and B histo-blood carbohydrates could be a strategy to mimicry host's tissue by modification of its cuticular surface as well as facilitate the escape of the host's immune response.…”

Section: Histo-blood Group-like Carbohydrates In Pathogenic Invermentioning

confidence: 99%

ABO, H, Lewis and Secretor histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates

Mattos¹,

Mattos²,

Miola³

2019

CMR

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ABO, H, Lewis, and Secretor histo-blood group systems express a repertoire of carbohydrate antigens in human hematopoietic and non-hematopoietic tissues. The oligosaccharide components of these systems are widely distributed in nature, including animal and plants. A set of reports demonstrated that pathogenic and non-pathogenic invertebrates are able to synthesize and or acquire histo-blood group-like carbohydrates from hosts. These abilities seem to be related to strategies for cell invasion as well as scape from host’s innate and adaptive immune responses. This text revised the literature and offers a tentative explanation for the presence of histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates and its importance in terms of evolution.

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ABO System: molecular mimicry of Ascaris lumbricoides

Cited by 4 publications

References 8 publications

H antigen presence in an Ascaris lumbricoides extract

H antigen presence in an Ascaris lumbricoides extract

Genome-Wide Identification of Molecular Mimicry Candidates in Parasites

ABO, H, Lewis and Secretor histo-blood group-like carbohydrates in pathogenic and non-pathogenic invertebrates

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