Clinical and laboratory findings of Plasmodium vivax malaria in Colombia, 2001

Echeverri, Marcela; Tobón, Alberto; Álvarez, Gonzalo; Carmona, Jaime; Blair, Silvia

doi:10.1590/s0036-46652003000100006

Cited by 71 publications

(70 citation statements)

References 14 publications

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“…The low frequency of neurological disorders among patients seen in the ambulatory contrasts with the high (58%) proportion among those hospitalized. Similarly, the occurrence of alterations in the respiratory, liver, and kidney functions are consistent with data reported by other authors in relation to malaria by Plasmodium vivax 8,18,19 . Noteworthy is the finding of jaundice in 2.1% of patients treated in ambulatory and in 58% of hospitalized patients, a sign that can lead to misdiagnosis, as observed in some patients who received an initial diagnosis of hepatitis.…”

Section: Rev Soc Bras Med Trop 46(1):67-72 Jan-feb 2013supporting

confidence: 92%

“…However, even if this statement is true for these regions, atypical manifestations denoting severity have been observed in an increasing way 6,8,15 . Signs and symptoms, such as vomiting, diarrhea, jaundice, drowsiness, mental confusion, seizures, loss of consciousness, bleeding, and dyspnea, that registered in a significant percentage of patients confirm these findings.…”

Section: Rev Soc Bras Med Trop 46(1):67-72 Jan-feb 2013mentioning

confidence: 94%

“…Parasite density has been identified as a sign of bad prognosis 8 . In this study, there was no statistical relation between the level of parasitemia and the severity of clinical manifestations.…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…Atypical manifestations and severe forms, however, have been registered and are characterized in particular by thrombocytopenia, jaundice, changes in level of consciousness, and severe anemia [5][6][7][8][9][10] . These events warn that more accurate observations of the disease should be made, especially in geographical areas where the species is predominant.…”

Section: Introductionmentioning

confidence: 99%

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Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Raposo

Santos

Santos³

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Malaria caused by Plasmodium vivax species has shown signs of severity, recorded with increasing frequency in the medical literature. This study aimed to characterize the signs of severe malaria by Plasmodium vivax in the State of Maranhão, Brazil. Methods: A descriptive cohort study of patients assisted in the field and a historical and concurrent study of a series of cases among hospitalized patients were undertaken to identify the clinical and laboratory signs of severity. Results: A total of 153 patients were included in the study, 13 of whom were hospitalized. Males made up the majority, numbering 103 (67.3%). The age of the patients ranged from 10 to 70 years, 92.2% were natives of the State of Maranhão, and 65% of the patients had had malaria before. The average time elapsed between symptom onset and diagnosis among outpatients was three days, while among hospitalized patients this average reached 15.5 days, a statistically significant difference (p=0.001). The parasitemia ranged from 500 to 10,000 parasites/µl in 92.8% of cases. The clinical and laboratory manifestations of severity were vomiting and diarrhea, jaundice, drowsiness, mental confusion, seizures, loss of consciousness, agitation, bleeding, pale skin, coughing and dyspnea, thrombocytopenia, anemia, elevation of nitrogenous compounds, and elevated transaminases and bilirubin. Conclusions: The monitoring of malaria patients with Plasmodium vivax showed the possibility of aggravation, the intensity of which varied in different circumstances, especially the interval time between falling ill and diagnostic confirmation.

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Section: Rev Soc Bras Med Trop 46(1):67-72 Jan-feb 2013supporting

confidence: 92%

Section: Rev Soc Bras Med Trop 46(1):67-72 Jan-feb 2013mentioning

confidence: 94%

Section: Conflict Of Interestmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Raposo

Santos

Santos³

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…The extent of liver involvement varies from a minimal abnormality in liver function tests to hepatic encephalopathy. [13][14][15] Chawla et al studied 31 patients, of whom 14 had serum bilirubin>10mg%, with predominantly conjugated hyperbilirubinaemia. 16 They attributed these elevated serum bilirubin levels to intravascular haemolysis and associated renal failure, leading to decreased excretion of bilirubin.…”

Section: Discussionmentioning

confidence: 99%

Study of clinical presentation of malaria and the associated liver profile changes in various species of plasmodia

Biradar

Holyachi

2016

Int J Res Med Sci

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Morbidity in the marshes: Using spatial epidemiology to investigate skeletal evidence for malaria in Anglo‐Saxon England (AD 410–1050)

Gowland

Western

2011

American J Phys Anthropol

102

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Concerns over climate change and its potential impact on infectious disease prevalence have contributed to a resurging interest in malaria in the past. A wealth of historical evidence indicates that malaria, specifically Plasmodium vivax, was endemic in the wetlands of England from the 16th century onwards. While it is thought that malaria was introduced to Britain during the Roman occupation (AD first to fifth centuries), the lack of written mortality records prior to the post-medieval period makes it difficult to evaluate either the presence or impact of the disease. The analysis of human skeletal remains from archaeological contexts is the only potential means of examining P. vivax in the past. Malaria does not result in unequivocal pathological lesions in the human skeleton; however, it results in hemolytic anemia, which can contribute to the skeletal condition cribra orbitalia. Using geographical information systems (GIS), we conducted a spatial analysis of the prevalence of cribra orbitalia from 46 sites (5,802 individuals) in relation to geographical variables, historically recorded distribution patterns of indigenous malaria and the habitat of its mosquito vector Anopheles atroparvus. Overall, those individuals living in low-lying and Fenland regions exhibited higher levels of cribra orbitalia than those in nonmarshy locales. No corresponding relationship existed with enamel hypoplasia. We conclude that P. vivax malaria, in conjunction with other comorbidities, is likely to be responsible for the pattern observed. Studies of climate and infectious disease in the past are important for modeling future health in relation to climate change predictions.

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Clinical and laboratory findings of Plasmodium vivax malaria in Colombia, 2001

Cited by 71 publications

References 14 publications

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Study of clinical presentation of malaria and the associated liver profile changes in various species of plasmodia

Morbidity in the marshes: Using spatial epidemiology to investigate skeletal evidence for malaria in Anglo‐Saxon England (AD 410–1050)

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