Seasonal variation of hepatitis A virus infection in the city of Rio de Janeiro, Brazil

Villar, Lívia Melo; Paula, Vanessa Salete de; Gaspar, Ana

doi:10.1590/s0036-46652002000500011

Cited by 32 publications

(27 citation statements)

References 12 publications

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“…In this study, carried out over eight years with patients suspected of having hepatitis, the rate of HAV acute infection positivity (anti-HAV-IgM positive) was 46.4%. This result is similar to those of other studies carried out in Brazil (Cardoso et al 2000, de Paula et al 2002, Villar et al 2002a, even when considering the viral RNA positivity in the analyzed serum samples (51.9%).…”

Section: Discussionsupporting

confidence: 92%

Prevalence of hepatitis A virus infection in Goiânia, Goiás, Brazil, by molecular and serological procedures, 1995-2002

Fiaccadori¹,

Soares

Borges³

et al. 2006

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 92%

Prevalence of hepatitis A virus infection in Goiânia, Goiás, Brazil, by molecular and serological procedures, 1995-2002

Fiaccadori¹,

Soares

Borges³

et al. 2006

Mem. Inst. Oswaldo Cruz

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“…Because the proportion of asymptomatic cases of hepatitis A is high, implementation of epidemiological surveillance actions is diffi cult and is usually limited to passive notifi cation of cases. As a result, it is diffi cult to estimate the magnitude of the disease and to make appropriate and timely decisions regarding the required interventions (29) . The pattern of prevalence of anti-hepatitis A virus (HAV) total antibodies varies among Brazilian regions.…”

Section: Hepatitis Amentioning

confidence: 99%

Progression of the load of waterborne and intestinal parasitic diseases in the State of Amazonas

Martins

Lacerda

Monteiro

et al. 2015

Rev. Soc. Bras. Med. Trop.

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42www.scielo.br/rsbmt I www.rsbmt.org.br Revista da Sociedade Brasileira de Medicina Tropical 48(Suppl I):42-54, 2015http://dx.doi. org/10.1590/0037-8682-0162-2014 Review Article ABSTRACT In the State of Amazonas, Brazil, urban expansion together with precarious basic sanitation conditions and human settlement on river banks has contributed to the persistence of waterborne and intestinal parasitic diseases. Time series of the recorded cases of cholera, typhoid fever, hepatitis A and leptospirosis are described, using data from different levels of the surveillance systems. The sources for intestinal parasitosis prevalence data (non-compulsory reporting in Brazil) were Medical Literature Analysis and Retrieval System Online (MEDLINE), Literatura Latino-Americana (LILACS) and the annals of major scientifi c meetings. Relevant papers and abstracts in all languages were accessed by two independent reviewers. The references cited by each relevant paper were scrutinized to locate additional papers. Despite its initial dissemination across the entire State of Amazonas, cholera was controlled in 1998. The magnitude of typhoid fever has decreased; however, a pattern characterized by eventual outbreaks still remains. Leptospirosis is an increasing cause of concern in association with the annual fl oods. The overall prevalence of intestinal parasites is high regardless of the municipality and the characteristics of areas and populations. The incidence of hepatitis A has decreased over the past decade. A comparison of older and recent surveys shows that the prevalence of intestinal parasitic diseases has remained constant. The load of waterborne and intestinal parasitic diseases ranks high among the health problems present in the State of Amazonas. Interventions aiming at basic sanitation and vaccination for hepatitis A were formulated and implemented, but assessment of their effectiveness in the targeted populations is still needed.

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“…HAV infection is a major public health problem in Brazil, accounting for the majority of reported cases of acute hepatitis (6,7). Transmission of HAV usually occurs by the fecaloral route.…”

Section: Introductionmentioning

confidence: 99%

Genetic variability of hepatitis A virus isolates in Rio de Janeiro: implications for the vaccination of school children

Villar

Lampe

Meyer

et al. 2004

Braz J Med Biol Res

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The epidemiology of hepatitis A virus (HAV) infection is shifting from high to intermediate endemicity in Brazil, resulting in increased numbers of susceptible individuals and a greater potential for the emergence of outbreaks. Universal vaccination against HAV has been recommended for children, but updated sero-epidemiological data are necessary to analyze the level of natural immunity and to identify candidates for preventive measures. In addition, more molecular studies are necessary to characterize the genotypes involved in HAV infections and outbreaks. Sera from 299 school children (5-15 years old) and 25 school staff members, collected during an outbreak of HAV at a rural public school in June 2000, were tested for IgM and total anti-HAV antibodies (ELISA). Viral RNA was amplified by RT-PCR from anti-HAV IgM-positive sera and from 19 fecal samples. Direct nucleotide sequencing of the VP1/2A region was carried out on 18 PCR-positive samples. Acute HAV infection was detected by anti-HAV IgM in 93/299 children and in 3/25 adult staff members. The prevalence of total anti-HAV antibodies in IgM-negative children under 5 years of age was only 10.5%. HAV-RNA was detected in 46% IgM-positive serum samples and in 16% stool samples. Sequence analysis showed that half the isolates belonged to subgenotype IA and the other half to IB. On the basis of these data, mass vaccination against HAV is recommended without prevaccination screening, especially for children before they enter school, since nearly 90% of the children under 5 years were susceptible. Molecular characterization indicated the endemic circulation of specific HAV strains belonging to subgenotypes IA and IB.

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Seasonal variation of hepatitis A virus infection in the city of Rio de Janeiro, Brazil

Cited by 32 publications

References 12 publications

Prevalence of hepatitis A virus infection in Goiânia, Goiás, Brazil, by molecular and serological procedures, 1995-2002

Prevalence of hepatitis A virus infection in Goiânia, Goiás, Brazil, by molecular and serological procedures, 1995-2002

Progression of the load of waterborne and intestinal parasitic diseases in the State of Amazonas

Genetic variability of hepatitis A virus isolates in Rio de Janeiro: implications for the vaccination of school children

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