Papular-purpuric "gloves and socks" syndrome due to parvovirus B19: report of a case with unusual features

Passoni, Luiz Fernando Cabral; Ribeiro, Sayonara Rocha; Giordani, Maria Lúcia L; Menezes, Juliana; Nascimento, Jussara Pereira do

doi:10.1590/s0036-46652001000300010

Cited by 17 publications

(20 citation statements)

References 17 publications

(31 reference statements)

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“…17 Bullous expression of the skin lesions has so far been reported in only three patients, all of whom were more than 35 years old. 10,12,16 Both extraacral localization of skin lesions and bullae were observed in our patient. The various oral manifestations, which have been described for more than half of PPGSS patients, 4 include petechiae, erythema and swelling, vesicles, aphthous ulcers and Koplik spots on the hard and soft palate and the labial and buccal mucosa.…”

Section: Discussionsupporting

confidence: 60%

“…The various oral manifestations, which have been described for more than half of PPGSS patients, 4 include petechiae, erythema and swelling, vesicles, aphthous ulcers and Koplik spots on the hard and soft palate and the labial and buccal mucosa. 10 The genital mucosa may be affected with painful edema, erythema, and small ulcers, sometimes accompanied by dysuria. 6,8,10 Conjunctivitis was described in two cases.…”

Section: Discussionmentioning

confidence: 99%

“…10 The genital mucosa may be affected with painful edema, erythema, and small ulcers, sometimes accompanied by dysuria. 6,8,10 Conjunctivitis was described in two cases. 1,16 Extracutaneous signs and symptoms may precede or occur simultaneously with the skin lesions and are usually mild and transient.…”

Section: Discussionmentioning

confidence: 99%

“…20 Parvovirus B19 has been described as the causative agent in about two-thirds of PPGSS cases. 21 However, in most of these reports, observation of antiparvovirus B19 immunoglobulin M antibodies and/or seroconversion were the sole methods to demonstrate the infection, [3][4][5]8,10,16,22,23 whereas molecular detection of virus-specific DNA by PCR was accomplished in only 10 cases from the serum 2,6,7,9,24,25 and in five cases from the skin. 2,6,7 Because of the high seroprevalence rate of 40% to 60% in the adult population of central Europe 26 and the possibility of cross-reactions for the immunoglobulin M antibody class (eg, measles, rubella, EpsteineBarr virus, and cytomegalovirus), 27 serologic recognition of the parvovirus B19 infection is no definite evidence for an etiologic implication.…”

Section: Discussionmentioning

confidence: 99%

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Bullous papular-purpuric gloves and socks syndrome in a 42-year-old female: Molecular detection of parvovirus B19 DNA in lesional skin

Frühauf

Massone

Müllegger

2009

Journal of the American Academy of Dermatology

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Bullous papular-purpuric gloves and socks syndrome in a 42-year-old female: Molecular detection of parvovirus B19 DNA in lesional skin

Frühauf

Massone

Müllegger

2009

Journal of the American Academy of Dermatology

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“…The exanthem often progresses rapidly from generalized erythema to a more petechial or papular/purpuric appearance, rarely with associated bullae. 6,39,40 The affected extremities are often pruritic and may be painful. Oral lesions frequently accompany the petechial/papular/purpuric transition and may manifest as petechiae, vesicles, pustules, aphthous ulcers, pharyngeal erythema, angular cheilitis, and Koplik spots.…”

Section: Discussionmentioning

confidence: 99%

Papular Purpuric Gloves and Socks Syndrome Due to Parvovirus B19 Infection

Ryscavage¹,

Galvin

2010

Infectious Diseases in Clinical Practice

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Papular purpuric gloves and socks syndrome (also known as gloves and socks syndrome) is a relatively newly described viral dermatosis with unique characteristics. These characteristics typically include an erythematous, papular, or petechial rash and edema in an acral distribution, often with associated mucosal lesions, arthralgias, and fever. We present a case of papular purpuric gloves and socks syndrome in a 46-year-old patient with acute parvovirus B19 infection, review the descriptive literature, and summarize our evolving understanding of this disease.(Infect Dis Clin Pract 2010;18: 128Y131) P apular purpuric gloves and socks syndrome (PPGSS, also known as gloves and socks syndrome) is a viral dermatosis first described nearly 20 years ago. Its manifestations typically include an erythematous, papular, or petechial rash and edema in an acral distribution, often with associated mucosal lesions, arthralgias, and fever. Our understanding of the epidemiology of this disease is growing, and new subtleties in clinical presentation have been described over the last several years. The viral etiology of this condition, ascribed originally exclusively to parvovirus B19, seems to be more complex, arguing for a possible immune-mediated pathogenic model. We describe a case of PPGSS in a 46-year-old patient with acute parvovirus B19 infection, review the descriptive literature, and summarize our evolving understanding of this disease. CASE HISTORYA 46-year-old male furniture worker with a past medical history significant only for hypertension presented to our institution with a 3-day history of swelling and rash confined to his hands and feet. His symptoms began with several hours of prodromal malaise and low-grade fever followed by the gradual onset of swelling of both hands followed by both feet. Later the same day, he began to note a progressive red rash of the skin of all of his distal extremities followed by the onset of dull arthralgias in his ankles and wrists. Finally, on the day of admission, he began to develop significant fevers and chills. The remainder of his joints were nonpainful, and he denied rash elsewhere. He reported recent urethral discharge but denied oral or genital lesions. He had been sexually active, was monogamous with his wife, and had not been using barrier protection. His only potential sick contact was a nephew with a flulike illness 10 days prior. He had not traveled outside the United States in several years.On admission, he was noted to be febrile (temperature, 103-C). He was hemodynamically stable (blood pressure, 108/58 mm Hg; pulse rate, 98 beats per minute), with an oxygen saturation of 98% without supplemental oxygen. His examination was notable for an absence of both oropharyngeal lesions and lymphadenopathy, an unremarkable cardiopulmonary examination, and symmetrical erythema and dense petechiae of both hands and feet with abrupt demarcation to normalappearing skin at the proximal wrists and ankles. In addition, all distal extremities were moderately edematous (Figs.

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