Schistosoma mansoni associated glomerulopathy

Td, Brito; Nussenzveig, I; Cr, Carneiro; Silva, Ana G.

doi:10.1590/s0036-46651999000500001

Cited by 16 publications

(15 citation statements)

References 35 publications

(42 reference statements)

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“…Studies in Brazil show that up to 15% of patients with hepatosplenic schistosomiasis also present renal disease [6][7][8][9][10][11][12][13][14] . In Egypt, Barsoum 15,16 reported that in 10% of patients on chronic hemodialysis, schistosomiasis was the primary cause of their renal failure.…”

Section: Introductionmentioning

confidence: 99%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. Methods: Sixty three patients (mean age 45.5±11 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosis of hepatosplenic schistosomiasis was based on epidemiological, clinical and parasitological data and imaging techniques. Eight patients, who presented >30mg/day albuminuria, were submitted to percutaneous ultrasound guided renal biopsy. Kidney tissue fragments were examined under light, direct immunofluorescence and electron microscopy. Results: All patients showed mesangial enlargement. In five, mesangial hypercellularity was observed and four presented duplication of the glomerular basement membrane. Areas of glomerular sclerosis were diagnosed in four. Deposits of immunoglobulin M and C3 were present in six samples; deposits of IgG in four, IgA in three and C1q in two samples. In all patients, immunoglobulin A was reported in the lumen of renal tubules. Deposits of kappa and lambda were observed in six samples. Electron microscopy revealed dense deposits in the glomerular tissue of three patients. Arterial hypertension, small esophageal varices, slight increases in serum creatinine and decreases in serum albumin were associated with glomerular disease. Conclusions: Renal disease associated with hepatosplenic schistosomiasis was verified in 12.7% of patients and type I membranoproliferative glomerulonephritis was observed in 50% of them. Schistosomal glomerulopathy still is an important problem in patients with hepatosplenic schistosomiasis in Brazil.

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Section: Introductionmentioning

confidence: 99%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…In the electronic microscopy, in the initial phases, there is mesangial expansion associated with mesangial cells hypertrophy and hyperplasia, as well as granular dense deposits, mainly in the subendothelial and mesangial regions [22,24] . In immunofluorescence, IgM, IgG and C3 deposits, with occasional IgA deposits, can be found [5] . Membranous glomerulopathy has not been a frequently found pattern in schistosomiasis.…”

Section: Histopathologymentioning

confidence: 99%

“…Considering all the forms of the disease, the incidence of glomerular involvement is estimated in 5%-6% and increases to 15% in the hepatosplenic form [5] . Glomerulonephritis is described in 10%-12% in autopsy studies [6] .…”

Section: S Mansonimentioning

confidence: 99%

“…In the infection by S. mansoni, circulating antigens of the adult parasite and its eggs can be found in different fluids and tissues of the host's body. The kidneys have an important role in these antigens deposits, and there is an important correlation between these circulating antigens and glomerular disease development [5] . Schistosoma antigens have been observed in the glomeruli of patients with focal and segmental glomerulosclerosis and mesangial proliferative glomerulonephritis [5] .…”

Section: Glomerular Lesion Pathogenesismentioning

confidence: 99%

“…Membranous glomerulopathy has not been a frequently found pattern in schistosomiasis. The correlation between this glomerulopathy and the parasitic disease has been questioned by some authors, based on clinical and experimental data [5] . Another possible histological pattern in schistosomiasis is amyloidosis, which can also be found in other chronic parasitic diseases [5] .…”

Section: Histopathologymentioning

confidence: 99%

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