Treatment of human scabies with oral ivermectin

Díaz, Ismael A. Conti; Amaro, J.

doi:10.1590/s0036-46651999000400011

Cited by 14 publications

(4 citation statements)

References 8 publications

(4 reference statements)

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“…Myiasis 41,42 and other ectoparasites 43,44 may be treated successfully with ivermectin. However, ivermectin is associated with impaired male fertility in mice, 45 rats, 46 cattle, 47 and sheep, 48 and with neonatal toxicity in rats 49 . Healthcare providers now face a serious lack of new commercial insecticides 35 …”

Section: Discussionmentioning

confidence: 99%

Control of the myiasis‐producing fly, Lucilia sericata, with Egyptian essential oils

Khater

Hanafy²,

Abdel-Mageed

et al. 2011

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Control of the myiasis‐producing fly, Lucilia sericata, with Egyptian essential oils

Khater

Hanafy²,

Abdel-Mageed

et al. 2011

Int J Dermatology

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“…With common scabies in immuno‐incompetent subjects, the cure rate reported in the five controlled studies of 29, 23, 19, 200 and 40 patients, respectively, were 79.3, 70, 95, 82.6 and 95% [26–30]. Five open studies of 11, 19, 38, 6 and 29 patients, respectively, found a cure rate of 100, 100, 76, 100 and 93% [31–35]. In these different studies, patients received a single dose of ivermectin [26–29,31,34,35] or a second dose 8 days later [30,32,33] ( and ).…”

Section: Efficacymentioning

confidence: 99%

Current treatments for scabies

Buffet

Dupin

2003

Fundamemntal Clinical Pharma

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Scabies is a frequent interhuman ectoparasitic infection. Several treatments are available worldwide. There are local treatments: synthetic pyrethrins, benzyl benzoate, lindane, crotamiton. Recently a few studies were published concerning ivermectin, systemic antiparasitic agent use in onchocercosis treatment. We reviewed the literature with an evidence-based medicine method. We attempt to answer two questions in particular: what is the treatment of choice for common scabies in a patient otherwise in good health? What is the role of systemic ivermectin? We also report specific situations. Among local treatments, studies are heterogeneous according to products, countries, group of treated patients, with or without contact subjects, and the method of treatment application. There are very few high proof-level controlled studies. In France, a combination of benzyl benzoate 10% and sulfiram 2% is used most, according to professional consensus. The most studied product is the cream permethrin 5%, available in the USA and UK. Its efficacy seems slightly superior to lindane and less toxic. It is more efficient than crotamiton. There is no study comparing benzyl benzoate and permethrin. Concerning systemic ivermectin, five controlled studies showed its efficiency in common scabies. But its relative efficiency over local treatment has not been established. A few open studies showed its efficacy in institutional epidemic, profuse scabies and in HIV-positive patients. Local treatment of choice in common scabies remains to be determined among the four principal molecules. There is no study comparing permethrin or esdepallethrin to benzyl benzoate. In what cases should we prescribe crotamiton or lindane? Indication of ivermectin seems proved in common scabies and probably for HIV-positive patients. It remains to be determined if it should be prescribed in the first instance, be double or triple, be associated or not with local treatment. In case of keratotic scabies, ivermectin seems interesting with two applications within 1 week, and should be associated with local treatment (duration remains to be defined). Ivermectin is probably useful in institutional epidemic, and therapeutic attitude remains to be defined. Ivermectin seems to have little or no risk. Treatment must be adapted case-by-case, according to feasibility. It is still important to treat contacts, and modality of this treatment remains to be specified.

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“…At the same time, adverse reactions to this drug have been reported 63–66 . Major overseas reports are cited in the references 56–66 . In addition, major domestic reports have also been cited 31,67–76 …”

Section: Treatment Of Scabiesmentioning

confidence: 99%

“…A number of reports have been published overseas concerning the efficacy of ivermectin against scabies 55 . Most of these reports affirmed the effectiveness of this drug 56–62 . At the same time, adverse reactions to this drug have been reported 63–66 .…”

Section: Treatment Of Scabiesmentioning

confidence: 99%

Guideline for the diagnosis and treatment of scabies in Japan (second edition)

2008

The Journal of Dermatology

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The guideline has been prepared by the Japanese Dermatological Association to ensure proper diagnosis and treatment of scabies, as oral therapy became available on August 2006 under health insurance and its clinical use was expected to increase. For making a proper diagnosis, the following three points should be taken into consideration: (i) clinical symptoms; (ii) detection of the mite (Sarcoptes scabiei); and (iii) epidemiological symptoms. The diagnosis is confirmed if the mites or eggs are identified by microscopy or dermoscopy and so forth. Topical sulfur preparations, with only limited usefulness, are the only available topical drugs approved by health insurance coverage for treating scabies. Currently, crotamiton, benzyl benzoate and γ-benzene hexachloride are also used clinically. It is important to apply these to the whole-body, including hands, fingers and genitals. The dose for ivermectin is a single administration p.o. of approximately 200 μg/kg bodyweight with water before a meal. Administration of a second dose is considered, if new specific lesions develop or the mites are detected. For treating crusted scabies, concomitant administration of oral ivermectin and the topical preparation is necessary. Some safe and useful topical drug preparations are needed to be approved by health insurance.

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Treatment of human scabies with oral ivermectin

Cited by 14 publications

References 8 publications

Control of the myiasis‐producing fly, Lucilia sericata, with Egyptian essential oils

Control of the myiasis‐producing fly, Lucilia sericata, with Egyptian essential oils

Current treatments for scabies

Guideline for the diagnosis and treatment of scabies in Japan (second edition)

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