[No Title Available]

Abstract

Mesangial IgA glomerulonephritis is now well documented as the commonest form of idiopathic glomerulonephritis and is a major cause of endstage renal failure in most countries. It has a high risk for progression (20%) and effective treatment is not available. The etiology of IgA nephropathy is unknown. As in other progressive glomerulonephritis converge on a common avenue of sclerosis, by which specialized cellular structures are replaced by collagen and mesenchymal matrix. Currently there is much attention being drawn to the possible modulation role that proteoglycans jointly with growth factor exert on this process. Until now is not clear if the IgA deposition is noxious to the glomerulus or intrinsically pathophysiologically important.