EUMYCETOMA BY Madurella grisea: REPORT OF THE FIRST CASE OBSERVED IN THE SOUTHERN BRAZILIAN REGION

Severo, L. C.; Vetoratto, Gerson; Oliveira, Flávio de Mattos; Londero, A. T.

doi:10.1590/s0036-46651999000200013

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…Thiabendazole, a commonly used antihelmintic, is effective in less than 50% 41 of patients, but its use is limited by gastrointestinal toxicities, especially at doses greater than 2 g daily 5,41 . A few case reports describe the clinical efficacy of terbinafine used alone 17,47 or in combination with heat therapy 50 . ESTERRE et al reported mycologic cure of chromoblastomycosis in 85.2% (23/27) of patients after 12 months of terbinafine therapy 18 .…”

Section: Discussionmentioning

confidence: 99%

Posaconazole treatment of refractory eumycetoma and chromoblastomycosis

Negroni

Tobón

Bustamante

et al. 2005

Rev. Inst. Med. trop. S. Paulo

135

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Eumycetoma and chromoblastomycosis are chronic, disfiguring fungal infections of the subcutaneous tissue that rarely resolve spontaneously. Most patients do not achieve sustained long-term benefits from available treatments; therefore, new therapeutic options are needed. We evaluated the efficacy of posaconazole, a new extended-spectrum triazole antifungal agent, in 12 patients with eumycetoma or chromoblastomycosis refractory to existing antifungal therapies. Posaconazole 800 mg/d was given in divided doses for a maximum of 34 months. Complete or partial clinical response was considered a success; stable disease or failure was considered a nonsuccess. All 12 patients had proven infections refractory to standard therapy. Clinical success was reported for five of six patients with eumycetoma and five of six patients with chromoblastomycosis. Two patients were reported to have stable disease. As part of a treatment-use extension protocol, two patients with eumycetoma who initially had successful outcome were successfully retreated with posaconazole after a treatment hiatus of > 10 months. Posaconazole was well tolerated during long-term administration (up to 1015 d). Posaconazole therapy resulted in successful outcome in most patients with eumycetoma or chromoblastomycosis refractory to standard therapies, suggesting that posaconazole may be an important treatment option for these diseases.

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Section: Discussionmentioning

confidence: 99%

Posaconazole treatment of refractory eumycetoma and chromoblastomycosis

Negroni

Tobón

Bustamante

et al. 2005

Rev. Inst. Med. trop. S. Paulo

135

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“…Madurella grisea) is phylogenetically-affiliated to the Trematosphaeriaceae family, suborder Massarineae in the Pleosporales order [6]. Although not so common, T. grisea has long been acknowledged as an exclusive agent of mycetoma in South America, more precisely in Brazil [10,11] and in Chile (but also in a submandibular abscess in India [6]. However, demonstration of its involvement in phaeohyphomycosis is more recent, maybe because there was previously a lack of correct identification [12].…”

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confidence: 99%

Successful Terbinafine Treatment for Cutaneous Phaeohyphomycosis Caused by Trematosphaeria grisea in a Heart Transplanted Man: Case Report and Literature Review

et al. 2020

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Phaeohyphomycosis is chronic infectious disease caused by dematiaceous fungi. It is characterized by the presence of pigmented septate mycelia within tissues. In case of superficial infection, the lesion(s) chronically evolve towards painless pseudo-tumors of the soft parts. We report herein the original case of a heart transplanted man who exhibited phaeohyphomycosis of the left hand, with no mention of travels in endemic areas. Trematosphaeria grisea was identified as the causative agent, which is quite innovative since this species has been rather described in mycetoma. The antifungal treatment initially based on isavuconazole alone was not sufficient to cure the patient. In contrast, its association with local terbinafine ointment allowed totalclinical improvement. This finding is unusual as diagnosis of phaeohyphomycosis caused by T. grisea is uncommon in non-tropical countries, and as the outcome appeared successful by the means of add-on therapeutic strategy with terbinafine.

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Phylogeny and typification of Madurella mycetomatis, with a comparison of other agents of eumycetoma

Hoog

Adelmann

Ahmed

et al. 2004

Mycoses

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The genus Madurella, described for non-sporulating agents of human mycetoma, is proven to be heterogeneous on the basis of rDNA small subunit (SSU) and Internal Transcribed Spacer (ITS) sequencing data. Madurella mycetomatis, the main agent of mycetoma in arid zones of Central and East Africa, probably belongs to the ascomycete order Sordariales. Madurella mycetomatis, the generic type species, is neotypified. Madurella grisea, with worldwide occurrence, is likely to be a member of the order Pleosporales, just as the mycetoma agents of Leptosphaeria, Pseudochaetosphaeronema, and Pyrenochaeta. Neotestudina rosatii belongs to the order Dothideales. Judging from ITS data, M. mycetomatis and N. rosatii are species complexes. The ex-type strain of N. rosatii, from a human mycetome, has an ITS sequence that deviates from that of environmental strains of the species.

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EUMYCETOMA BY Madurella grisea: REPORT OF THE FIRST CASE OBSERVED IN THE SOUTHERN BRAZILIAN REGION

Abstract: The first case of eumycetoma by Madurella grisea occurred in Southern Brazilian Region is herein related. In addition, Brazilian literature on this subject was reviewed and, the geographic distribution of this eumycetoma is presented.

Cited by 7 publications

References 8 publications

Posaconazole treatment of refractory eumycetoma and chromoblastomycosis

Posaconazole treatment of refractory eumycetoma and chromoblastomycosis

Successful Terbinafine Treatment for Cutaneous Phaeohyphomycosis Caused by Trematosphaeria grisea in a Heart Transplanted Man: Case Report and Literature Review

Phylogeny and typification of Madurella mycetomatis, with a comparison of other agents of eumycetoma

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