IL-2 AND IFN-&lt;FONT FACE=Symbol&gt;g&lt;/FONT&gt;, BUT NOT IL-4 SECRETION BY PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC) ARE RELATED TO CD4+ T CELLS AND CLINICAL STATUS IN BRAZILIAN HIV-1-INFECTED SUBJECTS

Hong, Marisa Ailin; Wakim, Valéria L; Salomão, S.; Camargo, L. S.; Casseb, Jorge; Duarte, Alberto José da Silva

doi:10.1590/s0036-46651998000600003

Cited by 11 publications

(11 citation statements)

References 12 publications

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“…In vitro HIV-1 infection of CD4 T cells results in a significant downmodulation of IL-2 mRNA expression that can be reversed by culturing cells in the presence of antiretroviral drugs (Fan et al, 1997). It is significantly decreased in patients with CD4 cell counts of <200 cells/mm 3 compared to those with higher CD4 counts (Hong et al, 1998). Similarly, deficiency of IL-2 production is one of the first immunological defects that can be demonstrated in HIV-infected individuals .…”

Section: Hiv-1 Alters Cytokine Secretion In Vitro and In Vivomentioning

confidence: 99%

“…It has a wide spectrum of activities including B-cell stimulation, monocyte differentiation and induction of IL-4 producing cells (Rincon et al, 1997). Similarly, IL-6 Esser et al, 1991Esser et al, ,1996Esser et al, ,1998 In vivo Sadeghi et al, 1995;Baqui et al, 2000 IL-2 CD4 T cells In vitro Fan et al, 1997 PBMC, CD4 T cells In vitro -gp160 stimulation Hu et al, 1994 PBMC In vivo Barcellini et al, 1994;Meroni et al, 1996;Meyaard et al, 1996;Hong et al, 1998 IL-4 PBMC, CD4 T cells In vivo Barcellini et al, 1994;Maggi et al, 1994;Imami et al, 1999 No change CD4 T cells In vivo Meyaard et al, 1996 CD4 T cells In vivo Re et al, 1992 IL-6 MDM In vitro Esser et al, 1991Esser et al, ,1996Esser et al, , 1998Foli et al, 1997 THP-1 Stimulation with HIV-1 glycoproteins gp41 or gp120 increases IL-6 production by the human monocytic cell line, THP-1, and mitogen-activated PBMC, respectively (Takeshita et al, 1995;Capobianchi, 1996).…”

Section: Hiv-1 Alters Cytokine Secretion In Vitro and In Vivomentioning

confidence: 99%

“…In vitro HIV-1 infection of CD4 T cells results in a significant downmodulation of IFN-γ mRNA expression, blocked by zidovudine treatment (Fan et al, 1997), but other investigators report enhanced secretion of IFN-γ in the culture supernatant (Vyakarnam et al, 1990). The production of IFN-γ in HIVinfected individuals decreases with disease progression (Clerici & Shearer, 1993;Hong et al, 1998). The production of IFN-γ in HIVinfected individuals decreases with disease progression (Clerici & Shearer, 1993;Hong et al, 1998).…”

Section: Ifn-γmentioning

confidence: 99%

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Cytokines and HIV-1: Interactions and Clinical Implications

Kedzierska

Crowe

2001

Antivir Chem Chemother

285

213

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Cytokines play an important role in controlling the homoeostasis of the immune system. Infection with HIV results in dysregulation of the cytokine profile in vivo and in vitro. During the course of HIV-1 infection secretion of T-helper type 1 (Th1) cytokines, such as interleukin (IL)-2, and antiviral interferon (IFN)-gamma, is generally decreased, whereas production of T helper type 2 (Th2) cytokines, IL-4, IL-10, proinflammatory cytokines (IL-1, IL-6, IL-8) and tumour necrosis factor (TNF)-alpha, is increased. Such abnormal cytokine production contributes to the pathogenesis of the disease by impairing cell-mediated immunity. A number of cytokines have been shown to modulate in vitro HIV-1 infection and replication in both CD4 T lymphocytes and cells of macrophage lineage. HIV-inductive cytokines include: TNF-alpha, TNF-beta, IL-1 and IL-6, which stimulate HIV-1 replication in T cells and monocyte-derived macrophages (MDM), IL-2, IL-7 and IL-15, which upregulate HIV-1 in T cells, and macrophage-colony stimulating factor, which stimulates HIV-1 in MDM. HIV-suppressive cytokines include: IFN-alpha, IFN-beta and IL-16, which inhibit HIV-1 replication in T cells and MDM, and IL-10 and IL-13, which inhibit HIV-1 in MDM. Bifunctional cytokines such as IFN-gamma, IL-4 and granulocyte-macrophage colony-stimulating factor have been shown to have both inhibitory and stimulatory effects on HIV-1. The beta-chemokines, macrophage-inflammatory protein (MIP)-1alpha, MIP-1beta and RANTES are important inhibitors of macrophage-tropic strains of HIV-1, whereas the alpha-chemokine stromal-derived factor-1 suppresses infection of T-tropic strains of HIV-1. This review outlines the interactions between cytokines and HIV-1, and presents clinical applications of cytokine therapy combined with highly active antiretroviral therapy or vaccines.

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Section: Hiv-1 Alters Cytokine Secretion In Vitro and In Vivomentioning

confidence: 99%

Section: Hiv-1 Alters Cytokine Secretion In Vitro and In Vivomentioning

confidence: 99%

Section: Ifn-γmentioning

confidence: 99%

See 1 more Smart Citation

Cytokines and HIV-1: Interactions and Clinical Implications

Kedzierska

Crowe

2001

Antivir Chem Chemother

285

213

View full text Add to dashboard Cite

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“…Interestingly, while reviewing the results in the literature, we did encounter HIV-1-positive-only cohorts, which utilized plasma, serum, and PBMC supernatants and drugs-of-abuse (cocaine) cohorts, which utilized plasma and PBMC supernatants for cytokine profiling. 4,7,20,28–31,45–59 However, to our knowledge, there were no reports of cytokine profiles on HIV-1-positive cohorts that included detailed longitudinal histories of cocaine use by members of a given cohort, as demonstrated here with the D rexel M ed HIV/AIDS Genetic Analysis Cohort.…”

Section: Discussionmentioning

confidence: 86%

Cocaine Alters Cytokine Profiles in HIV-1–Infected African American Individuals in the DrexelMed HIV/AIDS Genetic Analysis Cohort

Parikh

Dampier

Feng

et al. 2014

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background This study evaluated the relationship between illicit drug use and HIV-1 disease severity in HIV-1-infected patients enrolled in the DrexelMed HIV/AIDS Genetic Analysis Cohort. Since, cocaine is known to have immunomodulatory effects, the cytokine profiles of preferential nonusers, cocaine users, and multidrug users were analyzed to understand the effects of cocaine on cytokine modulation and HIV-1 disease severity. Methods Patients within the cohort were assessed approximately every 6 months for HIV-1 clinical markers and for history of illicit drug, alcohol, and tobacco use. The Luminex human cytokine 30-plex panel was used for cytokine quantitation. Analysis was performed using a newly developed biostatistical model. Results Substance abuse was common within the cohort. Utilizing the drug screens at the time of each visit, the subjects in the cohort were categorized as preferential nonusers, cocaine users, or multidrug users. The overall health of the nonuser population was better than that of the cocaine users, with peak and current viral loads in nonusers substantially lower than those in cocaine and multidrug users. Among the 30 cytokines investigated, differential levels were established within the 3 populations. The T-helper 2 cytokines, interleukin-4 and -10, known to play a critical role during HIV-1 infection, were positively associated with increasing cocaine use. Clinical parameters such as latest viral load, CD4+ T-cell counts, and CD4:CD8 ratio were also significantly associated with cocaine use, depending on the statistical model used. Conclusions Based on these assessments, cocaine use appears to be associated with more severe HIV-1 disease.

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“…Hong et al (1998) reported that proliferation responses to antigens are severely impaired by HIV infection.…”

Section: Introductionmentioning

confidence: 99%