GB virus C/Hepatitis G virus and other putative hepatitis non A-E viruses

Pinho, João Renato Rebello; Silva, Luiz Caetano da

doi:10.1590/s0036-46651996000600010

Cited by 3 publications

(2 citation statements)

References 81 publications

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“…First reports were initially available from hemodialysis patients with prevalence of 15%, or from patients with chronic liver diseases with a prevalence of 19% and 7% respectively [50], [51], [52]. The spread of GBV-C infection is also described in the general population ranging from 2% to 18% and the predominant genotypes were 2a, 2b and 1 [47], [53], [54], [55], [56], [57], [58].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil

et al. 2011

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BackgroundThe results of previous studies elsewhere have indicated that GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus type 1 (HIV-1) due to similar transmission routes of both viruses. The aim of this study was to determine the prevalence, incidence density and genotypic characteristics of GBV-C in this population.Methodology/Principal FindingsThe study population included 233 patients from a cohort primarily comprised of homosexual men recently infected with HIV-1 in São Paulo, Brazil. The presence of GBV-C RNA was determined in plasma samples by reverse transcriptase-nested polymerase chain reaction and quantified by real-time PCR. GBV-C genotypes were determined by direct sequencing. HIV viral load, CD4+ T lymphocyte and CD8+ T lymphocyte count were also tested in all patients. The overall prevalence of GBV-C infection was 0.23 (95% CI: 0.18 to 0.29) in the study group. There was no significant difference between patients with and without GBV-C infection and Glycoprotein E2 antibody presence regarding age, sex, HIV-1 viral load, CD4+ and CD8+T cell counts and treatment with antiretroviral drugs. An inverse correlation was observed between GBV-C and HIV-1 loads at enrollment and after one year. Also, a positive but not significant correlation was observed between GBV-C load and CD4+ T lymphocyte. Phylogenetic analysis of the GBV-C isolates revealed the presence of genotype 1 and genotype 2, these sub classified into subtype 2a and 2b.Conclusion/SignificanceGBV-C infection is common in recently HIV -1 infected patients in Sao Paulo, Brazil and the predominant genotype is 2b. This study provides the first report of the GBV-C prevalence at the time of diagnosis of HIV-1 and the incidence density of GBV-C infection in one year.

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Section: Introductionmentioning

confidence: 99%

Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil

et al. 2011

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“…Este virus fue denominado virus de la hepatitis G (HGV); sin embargo, al realizar los análisis de secuencias se demostro una alta homología (95%) con el virus GBV-C reportado anteriormente por Simons y cols. en 1995, por lo que se determinó que se trataba de dos aislados del mismo virus 15,16 . Finalmente, se terminó confirmando la clasificación del GBV-C/HGV dentro de la familia Flaviviridae.…”

Section: Descubrimiento Y Clasificaciónunclassified

Pegivirus humano: Potencial patogénico y riesgo de desarrollo de linfoma no Hodgkin

Arroyave-Ospina

Caicedo

Navas

et al. 2018

Rev. chil. infectol.

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The human pegivirus (HPgV), classified in the Flaviviridae family - Pegivirus genus, is an RNA virus identified in 1995. HPgV is a lymphotrophic virus, with replication sites in bone marrow and lymphoid tissue, as well as in peripheral blood mononuclear cells (PBMCs). Transmission is through sexual and parenteral routes, and recent estimations suggest nearly 750 million people are infected with HPgV worldwide. Almost 25% of infected individuals can develop persistent infection. Until now, HPgV has been considered a non-pathogenic virus; however, epidemiological studies suggest a potential role in lymphoproliferative diseases, particularly in the development of non-Hodgkin lymphoma (NHL). The evidence of this is controversial and the role of HPgV in lymphomagenesis has not yet been demonstrated. Several studies report a high prevalence of HPgV infection in patients with NHL compared to controls and patients with other hematological diseases. Therefore, analytic studies show that HPgV could be related to an increased risk of NHL development. Conversely, other studies indicate no association between HPgV and NHL, so the role of HPgV in lymphomagenesis is not clear. This review summarizes the main findings related to HPgV's pathogenic potential and association with NHL.

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Molecular prevalence and genotypes of human pegivirus-1 (HPgV-1) and SENV-like viruses among multiply transfused patients with beta-thalassemia

Bezerra

Santos

Silveira

et al. 2020

Transfusion and Apheresis Science

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GB virus C/Hepatitis G virus and other putative hepatitis non A-E viruses

Cited by 3 publications

References 81 publications

Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil

Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil

Pegivirus humano: Potencial patogénico y riesgo de desarrollo de linfoma no Hodgkin

Molecular prevalence and genotypes of human pegivirus-1 (HPgV-1) and SENV-like viruses among multiply transfused patients with beta-thalassemia

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