An exanthematic disease epidemic associated with coxsackievirus B3 infection in a day care center

Moreira, Regina Célia; Castrignano, Silvana Beres; Carmona, Rita de Cássia Compagnoli; Gomes, Filumena Maria da Silva; Saes, Sueli Gonsalez; Oliveira, Rosely S; Souza, Denise F. C.; Takimoto, Sueko; Costa, Marisa C. Lobo da; Waldman, Eliseu Alves

doi:10.1590/s0036-46651995000300009

Cited by 13 publications

(4 citation statements)

References 3 publications

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“…Complications are rare, but pneumonia, meningitis, rhabdomyolisis, or encephalitis may occur. It is associated with different strains of the coxsackievirus (CV), most commonly A16 (5,6), but also other A and B types (7–12) and enterovirus 71 (13).…”

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confidence: 99%

Onychomadesis Outbreak in Valencia, Spain Associated with Hand, Foot, and Mouth Disease Caused by Enteroviruses

Davia

Bel

Ninet

et al. 2011

Pediatric Dermatology

101

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This report evaluates the June 2008 onychomadesis outbreak in Valencia, Spain. The study sample consisted of 221 onychomadesis cases and 77 nonaffected individuals who lived close to those affected. We collected data on dietary variables, hygiene products, and individual pathological histories. Feces and blood specimens were collected from 44 cases and 24 controls to evaluate exposure to infectious agents. Pathological background data revealed a high frequency (61%) of hand, foot, and mouth disease among the onychomadesis cases. Coxsackievirus A10 was the most commonly detected enterovirus in both case and control groups (49%). Other enteroviruses such as coxsackieviruses A5, A6, A16, B1, and B3; echoviruses 3, 4, and 9; and enterovirus 71 were present in low frequencies in the case and control groups (3-9%). The 2008 onychomadesis outbreak in the metropolitan area of Valencia was associated with an outbreak of hand, foot, and mouth disease primarily caused by coxsackievirus A10.

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Onychomadesis Outbreak in Valencia, Spain Associated with Hand, Foot, and Mouth Disease Caused by Enteroviruses

Davia

Bel

Ninet

et al. 2011

Pediatric Dermatology

101

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“…No Brasil, foi descrita uma epidemia de doença exantemática em creche, acometendo 10 crianças de 7 a 13 meses de idade, onde foi isolado CV-B3 15 . Anterior ao presente estudo não há relatos do envolvimento de E-6 em caso de doença febril exantemática descrita no país.…”

Section: Discussionunclassified

Echovírus 6 associado à doença exantemática

Santos

Russo

Machado

et al. 2008

Rev. Soc. Bras. Med. Trop.

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Viral exanthems are a common problem in tropical regions, particularly affecting children. Various skin rashes have been reported in acute infections caused by Enterovirus. Biological samples from a child who presented generalized rashes were sent to the Enteric Virus Laboratory of the Adolfo Lutz Institute for laboratory diagnosis to be performed. A viral sample isolated from RD (human rhabdomyosarcoma cells) was subjected to the polymerase chain reaction and showed a 437-base pair product that was characteristic of the Enterovirus genus. Echovirus 6 (E-6) serotype was identified using the indirect immunofluorescence test. In addition, paired serum samples presented seroconversion to E-6. So far, there have not been any reports of E-6 involvement in exanthematic diseases in Brazil. Thus, the importance of epidemiological surveillance for these diseases and their complications is emphasized.

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“…EV-7 was found during the latter part of 2000, in addition to CV-A16 and EV-7, as a HFMD aetiologic agent 5 . In Brazil, MOREIRA et al, (1995) related an epidemic exanthematic disease associated with coxsackievirus B3 (CV-B3) 10 . No report about the association with EV-4 and HFMD is related in Brazil, maybe due to the lack of clinical suspicions.…”

Section: Discussionmentioning

confidence: 99%

Echovirus 4 associated to hand, foot and mouth disease

Russo

Luchs

Machado

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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SUMMARYHand, foot and mouth disease (HFMD) is a contagious enteroviral infection occurring primarily in children and characterized by vesicular palmoplantar eruptions and erosive stomatitis. Echovirus 4 (EV-4) has been commonly associated with aseptic meningitis. The association of HFMD with EV-4 has not been reported previously. Two samples of a 14-month child who presented mild fever, sores in the mouth, rash with blisters on the palm of hands and soles of feet were sent to Enteric Viruses Laboratory of Adolfo Lutz Institute. Clinical samples were inoculated in three different cell lines, and those which presented cytopathic effect (CPE), were submitted to Indirect Immunofluorescence Assay (IFA) and "one step" RT-PCR. Agarose gel electrophoresis from RT-PCR product, showed a product with 437 bp, which is characteristic of Enterovirus group. Echovirus 4 was identified by IFA. Although HFMD is a viral infection associated mainly with Enterovirus 71 (HEV-71) and Coxsackievirus A16 (CV-A16), our results demonstrate a diversity of serotype related to HFMD and stress the importance of epidemiological surveillance to this disease and its complications.

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An exanthematic disease epidemic associated with coxsackievirus B3 infection in a day care center

Cited by 13 publications

References 3 publications

Onychomadesis Outbreak in Valencia, Spain Associated with Hand, Foot, and Mouth Disease Caused by Enteroviruses

Onychomadesis Outbreak in Valencia, Spain Associated with Hand, Foot, and Mouth Disease Caused by Enteroviruses

Echovírus 6 associado à doença exantemática

Echovirus 4 associated to hand, foot and mouth disease

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