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New Insights in Medical Mycology

“…Infection by P. marneffei is presumed to occur by inhalation of conidia produced by the asexual development programme at 25°C, as has been noted for other dimorphic fungal pathogens such as Histoplasma capsulatum where infection occurs by inhalation of airborne conidia (Maresca & Kobayashi, 1989) or Coccidioides immitis due to inhalation of arthroconidial cells (Stevens, 1995). Once in the alveolar cavities of the lungs, alveolar macrophages, the primary defence response, engulf the fungal conidia.…”