Zigomicose nasofacial: relato de um caso do estado do Pará, Brasil

Moraes, Mário Augusto Pinto de; Almeida, Margarida Maria Roque; Veiga, Regina Celi C.; Sílveira, Fernando Tobias

doi:10.1590/s0036-46651994000200014

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…In humans and other animals, potassium iodide has been the traditional and effective treatment against Conidiobolus infections (Owens et al 1985). Several other drugs, such as: amphotericin B, cotrimoxazole, ketoconazole, itraconazole and fluconazole have been also effective in humans and animals with the disease (Moraes et al 1994, Valle et al 2001, Grooters 2003. Interestingly, in one case of rhinofacial form of the disease, the treatment with iodides of one affected animal with early clinical signs of the disease was partially successfully, suggesting that in the early form of the disease the treatment could be successful if it is initiated immediately after the observation of the first clinical signs.…”

Section: Discussionmentioning

confidence: 99%

Outbreaks of rhinofacial and rhinopharyngeal zygomycosis in sheep in Paraíba, northeastern Brazil

et al. 2008

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RESUMO.-[Surtos de zigomicose rinofacial e rinofarín-gea em ovinos na Paraíba.] Dois surtos de lesões rinofaciais e dois de lesões rinofaríngeas causadas por fungos com hifas filamentosas, raramente septadas, semelhantes às dos fungos entomophthorales, são descritos no Estado da Paraíba. Um surto da forma rinofacial afetou 5 ovinos durante a estação chuvosa. Outro surto desta forma clínica afetou um ovino de um grupo de 40, durante a época seca. Os sinais clínicos da forma rinofacial foram de corrimento serosanguinolento bilateral, com aumento de volume das Common clinical signs of the rhinofacial infection were bilateral serosanguineous nasal discharge with swelling of nostrils, upper lip, and the skin of the face. At necropsy the nasal mucosa showed dark brownish ulcerated areas which extended from the mucocutaneous region to 10cm inside the nasal vestibule. The mucosa of the hard palate was also ulcerated. The cutting surface of nostrils and palate showed a brownish or red spongeous tissue of friable consistency. One outbreak of rhinopharyngitis took place on an irrigated coconut farm; 7 out of 60 adult sheep were affected. Another outbreak affected a sheep in a flock of 80 during the dry season. Clinical signs as noisy respiration and dyspnoea due to mechanical blockage of the nasal cavities, swelling of the nostrils, and serosanguineous nasal discharge were observed. Six out of 8 sheep in this group showed exophthalmia, keratitis and unilateral corneal ulceration of the eye. The sheep either died of their infection or were euthanized after a clinical course of 7-30 days. At necropsy there was a dense yellow exudate in the nasopharyngeal area affecting the ethmoidal region, turbinate bones, paranasal sinuses, hard and soft palates, orbital cavity, pharynges, regional muscles and lymph nodes. Histopathologically both forms of the disease showed multifocal granulomas with an eosinophilic necrotic reaction (Splendore-Hoeppli phenomenon) containing ribbon type coenocytic hyphae with 7-30μm in diameter similar to hyphae of zygomycetous fungi, possibly Conidiobolus spp. Outbreaks of both forms of mycotic rhinitis are common in northeastern Brazil and in other regions of the country. narinas, lábio superior, e pele da face. Na necropsia, a mucosa nasal apresentava áreas ulceradas de cor marrom escuro, que se estendiam desde a região muco-cutánea até 10cm dentro do vestíbulo nasal. A mucosa do palato duro estava, também, ulcerada. A superfície de corte das narinas e palato apresentava-se marrom ou avermelhada de aspecto esponjoso e friável. Um surto de rinofaringite micótica ocorreu em uma plantação de coco irrigado, afetando 7 ovinos de um rebanho de 60 ovinos adultos. Outro surto desta forma da enfermidade afetou um único animal de um rebanho de 80, durante a época seca. Os animais apresentavam dispnéia, com respiração ruidosa devida ao bloqueio parcial das narinas, e corrimento nasal serosanguinolento. Seis dos oito animais afetados por esta forma da enfermidade apresentaram, em um olho, exoftalmia, ceratite e ul...

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Section: Discussionmentioning

confidence: 99%

Outbreaks of rhinofacial and rhinopharyngeal zygomycosis in sheep in Paraíba, northeastern Brazil

et al. 2008

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“…34 The main histologic lesion was the presence of multifocal granulomas with fungal hyphae surrounded by Splendore-Hoeppli material, which is characteristic of infections by Entomophthorales. 3,5,10,14,15,18,25,27,29,30,32,33,35 One important observation was the presence of vasculitis and thrombosis in the lesions of most sheep. Those lesions are rarely reported in infections by Entomophthorales, being more frequent in infection by Mucorales; such a characteristic has also been used to differentiate between mycosis caused by these 2 orders of fungi.…”

Section: Discussionmentioning

confidence: 99%

“…22 In humans, C. coronatus is the most common agent isolated causing infections of the upper airways. 2,22,29,35 In animals, conidiobolomycosis caused by C. coronatus, C. lamprauges, and C. incongruus are reported mainly as subcutaneous infections in horses, 6,18 llamas, 11,28 and dogs 12,14 and rhinofacial, nasopharyngeal, or oral infections in horses 3,13,16,21,24,26,27,36 and dogs. 1,12 In sheep, the disease has been reported in Australia 5,18 and Trinidad Tobago.…”

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confidence: 99%

Conidiobolomycosis in Sheep in Brazil

et al. 2007

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Abstract. Conidiobolomycosis is reported in the state of Piauí, in the semiarid region of northeastern Brazil. Affected sheep had depression, weight loss, serous or mucohemorrhagic nasal discharge, and cranium-facial asymmetry from exophthalmos of 1 eye, generally with increased volume of the eyeball, keratitis, and corneal ulceration. At necropsy of 60 sheep, friable masses were observed in the posterior region of the nasal cavity, often destroying the ethmoturbinate bones. Frequently, the lesions invaded the nasal sinuses, cribiform plate, orbit, and brain. The masses were irregular, granular with moist surfaces, and soft and friable with white, yellow, or tan coloration. Dissemination of the lesion to lungs was observed in 27 sheep, to the brain in 26, to lymph nodes in 3, to the kidney in 2, and to the gallbladder and heart in 1. The microscopic examination showed granulomatous inflammation composed of central necrosis surrounded by lymphocytes, epithelioid and giant cells, and fibrous tissue. In all lesions, negatively stained structures representing hyphae were surrounded by Splendore-Hoeppli material. Coagulative necrosis, thrombosis, and vasculitis were also observed. Grocott methenamine silver stain showed 8-30-mm-thick hyphae, rarely septate or ramified, irregular in shape, and with black contoured wall, sometimes with bulbous dilatation in the extremities. On electron microscopy, the hyphae had a thick double wall surrounded by cellular remnants and an inflammatory exudate. Conidiobolus coronatus was isolated from the lesions of 6 sheep. Conidiobolomycosis is an important disease of sheep in the state of Piauí, and other regions of northeastern Brazil.

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“…Many antifungal drugs, such as potassium iodide, amphotericin B, imidazole derivatives (fluconazole, ketoconazole, and itraconazole), or a combination of two of these drugs, 2,4,[7][8][9][10][11][12]16 have been used for the treatment of rinoentomophthoramycoses. In the present case, a good response was obtained after surgery and subsequent treatment with potassium iodide.…”

Section: Discussionmentioning

confidence: 99%

“…1 Approximately 35 cases of rhinoentomophthoramycosis have been reported in Brazil. [2][3][4][5][6][7][8][9][10][11][12] The disease begins as a tumefaction of the mucosa of the inferior turbinate that spreads to other parts of the nasal cavity, paranasal sinuses, and subcutaneous tissue of the nose and surrounding areas. The infection initially appears as a nasal obstruction followed by diffuse erythema and thickening of the skin of the nose.…”

Section: Introductionmentioning

confidence: 99%

Mucocutaneous Entomophthoramycosis Acquired by Conjunctival Inoculation of the Fungus

Bittencourt

Marback

Nossa

2006

The American Journal of Tropical Medicine and Hygiene

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Entomophthoramycoses are classified into subcutaneous, mucocutaneous, and primary visceral forms. The mucocutaneous form, also known as rhinoentomophthoramycosis, involves the mucosa and subcutaneous tissues of the nose and is caused by Conidiobolus coronatus (Entomophthora coronata). In this report, we describe the first case of mucocutaneous entomophthoramycosis acquired by introduction of the fungus through the conjunctival mucosa as a consequence of trauma involving contamination with soil. The patient was a 37-year-old man with no other complaints. The lesion was tumoral and extended into the ethmoidal and maxillary sinuses. The histopathologic appearance of the lesion was characteristic of this infection with a granulomatous process rich in eosinophils and with hyphae surrounded by an eosinophilic, periodic acid-Schiff stain-positive halo (Splendore-Hoeppli phenomenon). To the best of our knowledge, this case constitutes the first report of mucocutaneous entomophthoramycosis acquired by ocular contamination.

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Zigomicose nasofacial: relato de um caso do estado do Pará, Brasil

Cited by 7 publications

References 3 publications

Outbreaks of rhinofacial and rhinopharyngeal zygomycosis in sheep in Paraíba, northeastern Brazil

Outbreaks of rhinofacial and rhinopharyngeal zygomycosis in sheep in Paraíba, northeastern Brazil

Conidiobolomycosis in Sheep in Brazil

Mucocutaneous Entomophthoramycosis Acquired by Conjunctival Inoculation of the Fungus

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