Clinical and laboratorial features of visceral toxocariasis in infancy

Jacob, Cristina Miuki Abe; Pastorino, Antônio Carlos; Peres, Benedito Anselmo; Mello, E O; Okay, Yassuhiko; Oselka, Gabriel Wolf

doi:10.1590/s0036-46651994000100004

Cited by 44 publications

(27 citation statements)

References 23 publications

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“…Covert toxocariasis has been described as presenting non-specific symptoms, such as abdominal pain, headache, cough and limb pains. In some instances, neurological manifestations have been associated with the presence of Toxocara larvae in the brain 9,12 .…”

Section: Introductionmentioning

confidence: 99%

Potential immunological markers for diagnosis and therapeutic assessment of toxocariasis

Rubinsky-Elefant

Hoshino‐Shimizu

Jacob

et al. 2011

Rev. Inst. Med. trop. S. Paulo

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SUMMARYIn human toxocariasis, there are few approaches using immunological markers for diagnosis and therapeutic assessment. An immunoblot (IB) assay using excretory-secretory Toxocara canis antigen was standardized for monitoring IgG, IgE and IgA antibodies in 27 children with toxocariasis (23 visceral, three mixed visceral and ocular, and one ocular form) for 22-116 months after chemotherapy. IB sensitivity was 100% for IgG antibodies to bands of molecular weight [29][30][31][32][33][34][35][36][37][38][48][49][50][51][52][53][54] >205 kDa,[48][49][50][51][52][53][54] > 205 kDa, and 65.4% for IgA to 29-38, 48-54, 81-93 kDa. Candidates for diagnostic markers should be IgG antibodies to bands of low molecular weight (29-38 and 48-54 kDa). One group of patients presented the same antibody reactivity to all bands throughout the follow-up study; in the other group, antibodies decayed partially or completely to some or all bands, but these changes were not correlated with time after chemotherapy. Candidates for monitoring patients after chemotherapy may be IgG antibodies to > 205 kDa fractions, IgA to 29-38, 48-54, 81-93 kDa and IgE to 95-121 kDa. Further identification of antigen epitopes related to these markers will allow the development of sensitive and specific immunoassays for the diagnosis and therapeutic assessment of toxocariasis.

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Section: Introductionmentioning

confidence: 99%

Potential immunological markers for diagnosis and therapeutic assessment of toxocariasis

Rubinsky-Elefant

Hoshino‐Shimizu

Jacob

et al. 2011

Rev. Inst. Med. trop. S. Paulo

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“…Seroepidemiological studies to detect these antibodies have revealed high prevalence, particularly in children 11,13,19 and are important in patients with a peripheral eosinophilia above 400 eosinophils/mL 11,23 and patients showing clinical symptoms 17 .…”

Section: Introductionmentioning

confidence: 99%

Serological, clinical and epidemiological evaluation of toxocariasis in urban areas of south Brazil

Colli

Rubinsky-Elefant

Paludo

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYToxocariasis is a worldwide public-health problem that poses major risks to children who may accidentally ingest embryonated eggs of Toxocara. The objectives of this study were to investigate the occurrence of anti-Toxocara spp. antibodies in children and adolescents and the variables that may be involved, as well as environmental contamination by Toxocara spp. eggs, in urban recreation areas of north central mesoregion, Paraná State, Brazil. From June 2005 to March 2007. a total of 376 blood samples were collected by the Public Health Service from children and adolescents one to 12 years old, of both genders. Samples were analyzed by the indirect ELISA method for detection of anti-Toxocara antibodies. Serum samples were previously absorbed with Ascaris suum antigens, and considered positive with a reagent reactivity index ≥1. Soil samples from all of the public squares and schools located in the four evaluated municipalities that had sand surfaces (n = 19) or lawns (n = 15) were analyzed. Of the 376 serum samples, 194 (51.6%) were positive. The seroprevalence rate was substantially higher among children aging one to five years (p = 0.001) and six to eight years (p = 0.022). The clinical signs and symptoms investigated did not show a statistical difference between seropositive and seronegative individuals (p > 0.05). In 76.5% of the investigated recreation places, eggs of Toxocara were detected in at least one of the five collected samples. Recreation areas from public schools were 2.8 times more contaminated than from public squares. It is important to institute educational programs to inform families and educators, as well as to improve sanitary control of animals and cleaning of the areas intended for recreation in order to prevent toxocariasis.

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“…Alrededor de 80% de la población estudiada estaba entre los 5 y 44 años de edad. Es decir, la posibilidad de una infección que pueda afectar seriamente la visión puede comprometer la vida productiva de la población, lo cual coincide con otros reportes ( 2,17,20,21,23,25 ).…”

Section: Discussionunclassified

“…Si además consideramos que este problema ha sido reportado principalmente en individuos jóvenes ( 2,6,20,21 ), entonces se hace necesario determinar la verdadera frecuencia de este problema, para que los profesionales médicos de la especialidad sospechen del daño y sobre todo tengan la posibilidad de realizar el diagnóstico adecuado.…”

Section: Introductionunclassified

Toxocariosis humana en pacientes con lesión ocular

Espinoza

Huapaya

Ayllón³

et al. 2013

An Fac med

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RESUMENOBJETIVO: Estimar la prevalencia de toxocariosis humana en sujetos con sintomatología ocular sospechosa. MATERIAL Y MÉTODOS: Se estudió personas atendidas en servicios de Oftalmología de varios hospitales de Lima, quienes luego de la evaluación especializada presentaban síntomas y lesiones compatibles con toxocariosis intraocular. Se obtuvo muestras de sangre de cada participante y se realizó serología para Toxocara mediante la técnica de ELISA, así mismo recuento de leucocitos y fórmula diferencial. También se aplicó una encuesta epidemiológica para identificar conductas que pudieran asociarse a mayor riesgo de infección. RESULTADOS: Se estudió 45 personas, 19 varones y 26 mujeres; el 55,6% fue reactivo en la prueba de ELISA. No hubo diferencias en cuanto a sexo y el resultado de serología; entre los participantes de 15 y 44 años, se encontró 63% de reactivos. No se evidenció diferencias significativas con los factores epidemiológicos estudiados. Tampoco se observó asociación entre el hallazgo de eosinofilia y el resultado de la serología. CONCLUSIÓN: La infección humana por Toxocara es frecuente en sujetos clínicamente sospechosos y afecta principalmente a población en edad productiva, por lo que debería buscarse precozmente la infección para prevenir complicaciones. Palabras clave: Toxocariasis; toxocara; ELISA; oftalmopatías; serodiagnóstico. HUMAN TOXOCARIOSIS IN PATIENTS WITH OCULAR DAMAGE SUMMARYOBJECTIVE: To determine human toxocariosis prevalence in subjects presenting suspicious ocular symptoms. MATERIAL AND METHODS: Subjects with symptoms and suspicion of intraocular toxocariosis damage attended at various Lima hospitals ophtalmology services were studied. Blood samples were obtained and Toxocara serology by ELISA technique was done, along with leukocyte counts. An epidemiological questionnaire was also applied to identify behaviors associated to infection risk. RESULTS: Forty-five persons were studied, 19 male and 26 female, 55,6% were reactive by ELISA test. No differences in sex and serology results were observed; among participants between 15 and 45 years old, 63% were reactive. There were no significant differences in the epidemiological factors studied. No association between eosinophilia and serology was observed. CONCLUSIONS: Human infection by Toxocara is frequent in people with clinical symptoms and affects mainly to productive age population. We suggest active search for the infection in order to prevent complications.

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Clinical and laboratorial features of visceral toxocariasis in infancy

Cited by 44 publications

References 23 publications

Potential immunological markers for diagnosis and therapeutic assessment of toxocariasis

Potential immunological markers for diagnosis and therapeutic assessment of toxocariasis

Serological, clinical and epidemiological evaluation of toxocariasis in urban areas of south Brazil

Toxocariosis humana en pacientes con lesión ocular

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