The effect of chronic ingestion of ethanol on modulation of granulomatous inflammation in experimental schistosomiasis in mice

Castro, Lúcia Porto Fonseca de; Bambirra, Eduardo Alves; Coelho, Paulo Marcos Zech; Silva, Marcelo Eustáquio

doi:10.1590/s0036-46651993000500001

Cited by 5 publications

(1 citation statement)

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“…Analogies are evident in other parasite systems. For example, human daily ethanol ingestion has a positive association with frequency of Strongyloides stercoralis infection (Marques et al, 2010); chronic alcohol ingestion significantly reduces granuloma and hepatic fibrous tissue in mice infected with S. mansoni (Orrego et al, 1981; Castro et al, 1993); and a high-fat diet has a prominent effect on the course of chronic schistosomiasis mansoni in mice (Alencar et al, 2009). Modern molecular techniques are needed for better characterization of this phenomenon.…”

Section: Future Directionsmentioning

confidence: 99%

Effects of the Environment on Developmental Plasticity and Infection Success of Schistosoma Parasites – An Epigenetic Perspective

2019

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Evidence of how environmental cues affect the phenotypes of, and compatibility between Schistosoma mansoni and their hosts come from studies in environmental parasitology and research on host diet and chemotherapeutic treatment. Schistosomes deal with a multitude of signals from the water environment as well as cues that come from their hosts, particularly in response to molecules that serve to recognize and destroy them, i.e., those molecules that arise from their hosts’ immune systems. These interactions shape, not only the parasite’s morphology, metabolism and behavior in the short-term, but also their infection success and development into different stage-specific phenotypes later in their life cycle, through the modification of the parasite’s inheritance system. Developmental phenotypic plasticity of S. mansoni is based on epigenetic mechanisms which are also sensitive to environmental cues, but are poorly understood. Here, we argue that specific cues from the environment could lead to changes in parasite development and infectivity, and consequently, environmental signals that come from environmental control measures could be used to influence S. mansoni dynamics and transmission. This approach poses a challenge since epigenetic modification can lead to unexpected and undesired outcomes. However, we suggest that a better understanding of how environmental cues are interpreted by epigenome during schistosome development and host interactions could potentially be applied to control parasite’s virulence. We review evidence about the role of environmental cues on the phenotype of S. mansoni and the compatibility between this parasite and its intermediate and definitive hosts.

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