Candida albicans: cellular and molecular biology

Prasad, Rajendra

doi:10.1590/s0036-46651993000400021

Cited by 14 publications

(14 citation statements)

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“…Membranes composed predominantly of saturated fatty acids tend to be relatively rigid. In contrast, polyunsaturated fatty acids possess multiple, restrictive double bonds which promote lipid disorder, translating into increased membrane fluidity (29,42). In each of the three tPMP-1 r strains studied, there was a substantial shift in fatty acid content toward a predominance of polyunsaturated species.…”

Section: Discussionmentioning

confidence: 96%

In Vitro Resistance of Staphylococcus aureus to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Alterations in Cytoplasmic Membrane Fluidity

et al. 2000

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Section: Discussionmentioning

confidence: 96%

In Vitro Resistance of Staphylococcus aureus to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Alterations in Cytoplasmic Membrane Fluidity

et al. 2000

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“…cycloheximide, benomyl and methotrexate, than Saccharomyces cerevisiae [1,2]. In addition, the incidence of C. albicans cells acquiring resistance to azoles and polyenes has increased considerably in recent years, which has posed serious problems for its successful chemotherapy [3].…”

Section: Introductionmentioning

confidence: 99%

Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones

Krishnamurthy

1998

FEMS Microbiology Letters

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We have examined the expression of CDR1 (Candida drug resistance gene) in different stress conditions. There was a significant but transient enhancement of CDR1 expression associated with elevated temperatures. Most noteworthy transcriptional activation was observed with miconazole and vinblastine. Interestingly, L-estradiol and progesterone were also able to enhance CDR1 expression. Elevated levels of CDR1 and CDR2 (a homologue of CDR1) mRNA were found in some azole-resistant clinical isolates of C. albicans. CaMDR1 (benomyl-resistant) expression, however, did not differ among all the resistant isolates. Our results confirm the existence of multiple mechanisms of azole resistance in C. albicans. z 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.

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“…The solvents used to solublise di¡erent drugs were also tested and there was no inhibition of growth due to the solvents used. 2 The value given in parenthesis denotes the amount in Wg of drugs, added on to the ¢lter disk during the ¢lter disk assay. Ã The given values are in cm.…”

Section: U10mentioning

confidence: 99%

Membrane fluidity affects functions of Cdr1p, a multidrug ABC transporter of Candida albicans

Krishnamurthy

1999

FEMS Microbiology Letters

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Earlier, we have shown that the overexpression of an ABC transporter, CDR1, is involved in the emergence of multidrug resistance in Candida albicans. In this study, we checked its function in vivo by expressing it in different isogenic Saccharomyces cerevisiae erg mutants, which accumulated various intermediates of the ergosterol biosynthesis and thus altered the membrane fluidity. Functions like the accumulation of rhodamine 123, L-estradiol, fluconazole and floppase activity associated with Cdr1p were measured to ascertain their responses to an altered membrane phase. The floppase activity appeared to be favoured by an enhanced membrane fluidity, while the effluxing of substrates and Cdr1p's ability to confer multidrug resistance were significantly reduced. We demonstrate that only some of the functions of Cdr1p were affected by an altered lipid environment. z

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Candida albicans: cellular and molecular biology

Cited by 14 publications

References 0 publications

In Vitro Resistance of Staphylococcus aureus to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Alterations in Cytoplasmic Membrane Fluidity

In Vitro Resistance of Staphylococcus aureus to Thrombin-Induced Platelet Microbicidal Protein Is Associated with Alterations in Cytoplasmic Membrane Fluidity

Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones

Membrane fluidity affects functions of Cdr1p, a multidrug ABC transporter of Candida albicans

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