Dexamethasone does not reduce the worm burden in mice infected with in vivo obtained schistosomules of Schistosoma mansoni

Hermeto, Marco Victor; Melo, Alan Lane de; Bicalho, Rosilene Siray; Vargas, Antônio Pedro; Favaretto, Fábio J. O.; Pereira, Leandro de Mattos

doi:10.1590/s0036-46651993000400016

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Cited by 6 publications

(1 citation statement)

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“…In agreement with the results of Lambertucci et al (1989), our results showed an insignificant effect of dexamethasone on parasite number. However, investigators who used hydrocortisone or a dose of dexamethasone 50-fold higher than ours reported a decrease in the parasite burden (Coker 1957, Hermeto et al 1993.…”

Section: Discussioncontrasting

confidence: 57%

Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni

Aly

Hendawy

Ali

et al. 2010

Mem. Inst. Oswaldo Cruz

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Section: Discussioncontrasting

confidence: 57%

Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni

Aly

Hendawy

Ali

et al. 2010

Mem. Inst. Oswaldo Cruz

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Immune changes of Schistosoma japonicum infections in various rodent disease models

Shen

et al. 2012

Experimental Parasitology

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Dexamethasone, a Drug for Attenuation ofSchistosoma mansoniInfection Morbidity

Pyrrho

Ramos²,

Neto³

et al. 2002

Antimicrob Agents Chemother

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To investigate the possible use of immunomodulators as coadjuvants in the treatment of chronic schistosomiasis, the study described in the present report evaluated the effects of dexamethasone on several parameters which reflect disease severity and morbidity. Parasitological, immunological, and histological parameters were analyzed in animals treated from the first day of infection or after 35 days of infection. In both situations, dexamethasone had no effect on the parasite burden but altered the egg distribution in tissue, indicating that under the schedule used it did not interfere with the development of adult worms or oviposition. Treated mice showed a decrease in the number of eggs in hepatic tissue, reduced granuloma sizes, reduced levels of granuloma maturation, and reduced collagen contents. Dexamethasone-treated mice also had decreased gamma interferon, interleukin-12 (IL-12), and IL-4 levels in serum and increased IL-10 levels in serum. Taken together, these data suggested a decrease in the severity of murine schistosomiasis and point to dexamethasone as a convenient and promising coadjuvant agent in the therapy of this infection.

show abstract

Dexamethasone does not reduce the worm burden in mice infected with in vivo obtained schistosomules of Schistosoma mansoni

Cited by 6 publications

References 5 publications

Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni

Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni

Immune changes of Schistosoma japonicum infections in various rodent disease models

Dexamethasone, a Drug for Attenuation ofSchistosoma mansoniInfection Morbidity

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