Fulminant Labrea Hepatitis - the role of hepatitis A (HAV), B (HBV), C (HCV), and D (HDV) infection: preliminary report

Fonseca, José Carlos Ferraz da; Ferreira, Luíz Carlos Lima; Brasil, Leila Melo; Castinho, Marcia da Costa; Moss, Robson; Barone, M.

doi:10.1590/s0036-46651992000600017

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…The four oldest studies had their data collected in the 1980s 14,[16][17][18] and had the highest HDV infection prevalence in the meta-analysis (Figure 3B), contributing to overestimated pooled HDV infection prevalence; however, a cumulative meta-analysis could confirm that the epidemiological profile of this virus has undergone significant changes (p<0.001), with successive reductions since 1990s. Nearly all analyzed studies reported cross-sectional observational design (27/31; 87.10%), although the presence of other designs had been observed (cohort, case control and case series).…”

Section: Source Of Heterogeneity and Subgroup Analysismentioning

confidence: 99%

“…The pooled HDV prevalence estimate was 22.37% (95%CI: 13.72-32.26) in South America by meta-analysis [13][14][15][16][17][18][19][20][21][22] . This geographical region is traditionally recognized as endemic for hepatitis delta and a higher frequency for this virus was previously expected 2 .…”

Section: /12mentioning

confidence: 99%

“…Extreme caution should be exercised regarding the interpretation of the estimated prevalence for South America, due to selection biases observed during study review. These biases have been caused by the absence of information from several countries located far from the Amazon basin, as well as the use of data collected by studies conducted in the 1980s 1,2,5,6 and 1990s 3,4,[7][8][9][10][11][12][13][14][15][16][17]21 , which led to an overestimation of HDV infection cases in the studied area.…”

Section: /12mentioning

confidence: 99%

“…In Latin America, HDV has been associated with acute and chronic infection, particularly severe and fulminant hepatitis. The study area was based on articles already reporting high HDV endemicity in South America, since the 1980s [13][14][15][16][17][18][19] . There are relatively few data on HDV prevalence in South American countries and most of them are regional cross-sectional studies 1,2,[20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis Delta Prevalence in South America: A Systematic Review and Meta-Analysis

Scarponi

Silva

Filho

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Hepatitis delta virus (HDV) has been associated with acute or chronic hepatitis in Latin America, but there is no prevalence study covering South American countries. This meta-analysis aimed to estimate anti-HDV prevalence through a systematic review of published articles in English, Portuguese and Spanish until December 2017. Searches were conducted in Health Virtual Library, Capes, Lilacs, PubMed, and SciELO, according to defined criteria regarding participant selection and geographical setting. Study quality was assessed using the GRADE guidelines. Pooled anti-HDV prevalence was calculated using the DerSimonian-Laird random-effects model with Freeman-Tukey double arcsine transformation. Out of the 405 identified articles, only 31 met the eligibility criteria for inclusion in the meta-analysis. In South America, pooled anti-HDV prevalence among hepatitis B virus carriers was 22.37% (95% confidence interval: 13.72-32.26), though it appeared less frequently in some countries and populations, according to the data collection date. The findings indicated significant successive reductions in anti-HDV prevalence over thirty years. However, there was a scarcity of HDV epidemiological studies outside the Amazon Basin, notably in the Southwest continent and absence of target population standardization. There was a high HDV prevalence in South American countries, despite differences in methodological characteristics and outcomes, highlighting a drastic decline in the last decades. Future studies should identify HDV prevalence estimates in other regions of the continent and identify risk factors.

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Section: Source Of Heterogeneity and Subgroup Analysismentioning

confidence: 99%

Section: /12mentioning

confidence: 99%

Section: /12mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hepatitis Delta Prevalence in South America: A Systematic Review and Meta-Analysis

Scarponi

Silva

Filho

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…Investigations among Yucpa Indians in Venezuela were the first to disclose in an open community the importance of HDV superinfection as the cause of large outbreaks of fulminant hepatitis in populations with a high pre‐existing HBV endemicity 29,30 . A similar association has come to be recognized for previous epidemics of FH in Brazil and Colombia 30–32 . Cases of FH due to dual HBV and HDV infection are becoming less common in southern Europe, consequent to the prevalence of HDV decreasing substantially in recent years 33 .…”

Section: Fulminant Hepatitis Due To Hepatitis Viruses a To Ementioning

confidence: 94%

Acute liver failure: Established and putative hepatitis viruses and therapeutic implications

Williams

Riordan

2000

J of Gastro and Hepatol

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Any virus that can cause an acute hepatitis will, on occasion, give rise to acute liver failure. Such infections can be separated into those due to the primary hepatitis viral infections A to E and those where hepatitis occurs as part of a systemic viral infection, as with infection with, for instance, Epstein-Barr virus, cytomegalovirus, Varicella zoster virus, adenovirus and Herpes simplex virus. In general, the frequency with which the different hepatitis viruses are responsible for acute liver failure is related to their underlying prevalence in particular countries. An apparent exception is the striking geographical variation in the reported prevalence of acute liver failure due to hepatitis C virus infection, with a much higher proportion of cases generally attributed to this agent in Japan and Taiwan than in Western countries. Recent work has focused on the possible importance of mutant hepatitis B viral strains, co- and super-infection with known hepatitis viruses and certain newly described agents that may account for otherwise unexplained cases of acute liver failure. Despite an improved understanding of the pathogenesis of complicating cerebral oedema and advances in general supportive care, it is likely that the most severely affected patients with acute liver failure due to viral causes will survive only with liver transplantation, at least until approaches for promoting adequate liver regeneration are successfully developed and implemented.

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Hepatitis D Virus

Paraná

Schinoni

Campos

2017

Human Virology in Latin America

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Fulminant Labrea Hepatitis - the role of hepatitis A (HAV), B (HBV), C (HCV), and D (HDV) infection: preliminary report

Cited by 10 publications

References 10 publications

Hepatitis Delta Prevalence in South America: A Systematic Review and Meta-Analysis

Hepatitis Delta Prevalence in South America: A Systematic Review and Meta-Analysis

Acute liver failure: Established and putative hepatitis viruses and therapeutic implications

Hepatitis D Virus

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