Malaria: a publication of the Tropical Programme of the Wellcome Trust.

Knell, A.J.

doi:10.1590/s0036-46651992000100016

Cited by 5 publications

(12 citation statements)

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“…When sporozoites enter the peripheral blood they localise directly to the liver, invade hepatocytes and perform asexual reproduction (hepatic schizogony) to generate intracellular liver schizonts. [14][15][16] A quiescent form of parasite, the hypnozoite, also exists within hepatocytes for P. vivax and P. ovale but not P. falciparum. 14,17 Hypnozoites are responsible for persistence of infection when malaria relapses after the original challenge has been cleared.…”

Section: Plasmodium Life Cycle and Disease Pathophysiologymentioning

confidence: 99%

“…These invade erythrocytes and go through another asexual reproductive cycle (erythrocytic schizogony). 14,16 Merozoites metabolise haemoglobin and develop into trophozoites, then schizonts. When each erythrocyte bursts, further merozoites are released, increasing greatly the parasitaemia, the parasite load of the blood; this induces the manifestations of acute uncomplicated malaria.…”

Section: Plasmodium Life Cycle and Disease Pathophysiologymentioning

confidence: 99%

“…Severe P. falciparum infection (complicated malaria) can present in several ways including cerebral malaria (cytoadherence of infected erythrocytes within the vasculature of the brain with neurological sequelae), severe anaemia, renal disease and pulmonary oedema, and these complications collectively cause the majority of deaths. 16 Hence, the rationale for pre-erythrocytic vaccine development is the elimination of infection before release of parasites into the blood with which morbidity and mortality are associated.…”

Section: Plasmodium Life Cycle and Disease Pathophysiologymentioning

confidence: 99%

“…39 Designed to elicit sterile immunity against antigens present on inoculated sporozoites or expressed by schizont-infected hepatocytes, their effectiveness is predicated on blocking hepatocyte invasion and thus the development of merozoites, which would otherwise invade erythrocytes. 16 With a relatively long period within which to operate (seven days for P. falciparum) and few infectious organisms with which to deal, this a promising stage to target. 40 As it is a clinically silent stage an effective vaccine would both halt transmission and prevent clinical symptoms developing.…”

Section: Malaria Vaccines -Current Statusmentioning

confidence: 99%

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Advancement Towards an Approved Vaccine to Target Plasmodium Falciparum Malaria

Taylor‐Robinson

2014

IJI

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Abstract:Plasmodium falciparum causes the severest form of malaria which kills well over one million persons each year, chiefly children, and results in significant debilitation in hundreds of millions more. This disease has a dramatic socioeconomic impact in endemic countries and thus it is a recurring target for global health enterprises. Increased investment in existing control measures, including insecticide-impregnated bed nets, has been paired with revitalized efforts to develop an efficacious vaccine. Sequencing of the genome of P. falciparum has provided insights into the malaria parasite's complex lifecycle, which, combined with a deeper understanding of the human immune response to infection, has yielded many novel candidate vaccines during the past two decades. Most notable of these is RTS,S which has shown great promise over a long development process, becoming the first candidate vaccine against human malaria to advance to phase III clinical trials. Hence, there is optimism that in the near future RTS,S may become the first ever licensed vaccine against a parasitic disease in humans. However, this is qualified by the need for a better knowledge of its mechanism of protection and questions raised over its long-term therapeutic capacity. While the availability of RTS,S as a validated commercial product is not guaranteed, it is likely to contribute to the continuing campaign against malaria, if only as a forerunner to a fine-tuned second generation vaccine.

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Section: Plasmodium Life Cycle and Disease Pathophysiologymentioning

confidence: 99%

Section: Plasmodium Life Cycle and Disease Pathophysiologymentioning

confidence: 99%

Section: Plasmodium Life Cycle and Disease Pathophysiologymentioning

confidence: 99%

Section: Malaria Vaccines -Current Statusmentioning

confidence: 99%

See 2 more Smart Citations

Advancement Towards an Approved Vaccine to Target Plasmodium Falciparum Malaria

Taylor‐Robinson

2014

IJI

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“…Malaria is a vector-borne disease transmitted through the bite of anopheline mosquitoes, the only genus that transmits human malaria 26,47 . In America, the most important species of Anopheles are: An.…”

Section: Introductionmentioning

confidence: 99%

Sharing of antigens between Plasmodium falciparum and Anopheles albimanus

Wide

Capaldo²,

Zerpa

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe presence of common antigens between Plasmodium falciparum and Anopheles albimanus was demonstrated. Different groups of rabbits were immunized with: crude extract from female An. albimanus (EAaF), red blood cells infected with Plasmodium falciparum (EPfs), and the SPf66 synthetic malaria vaccine. The rabbit´s polyclonal antibodies were evaluated by ELISA, Multiple Antigen Blot Assay (MABA), and immunoblotting. All extracts were immunogenic in rabbits according to these three techniques, when they were evaluated against the homologous antigens. Ten molecules were identified in female mosquitoes and also in P. falciparum antigens by the autologous sera. The electrophoretic pattern by SDS-PAGE was different for the three antigens evaluated. Cross-reactions between An. albimanus and P. falciparum were found by ELISA, MABA, and immunoblotting. Anti-P. falciparum and anti-SPf66 antibodies recognized ten and five components in the EAaF crude extract, respectively. Likewise, immune sera against female An. albimanus identified four molecules in the P. falciparum extract antigen. As far as we know, this is the first work that demonstrates shared antigens between anophelines and malaria parasites. This finding could be useful for diagnosis, vaccines, and the study of physiology of the immune response to malaria.

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Functional genomics and developmental transcriptomics of the mosquito malaria vector Anopheles gambiae

Koutsos¹

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In 1730 Dr Thomas Fuller wrote: 'Can any man, can all the Men in the World, tho' assisted by Anatomy, Chymistry, and the best Glasses, pretend positively and certainly to tell us, what particles, how sized, figured, situated, mixed, moved, and how many of them, are requisite to produce a quartan ague, and how they specifically differ from those of a tertian … ?'We are now able to tell all these things. They have been written in hundreds of books, and are familiar to thousands of students. Those who belittle the powers of science are not always, perhaps, the wisest of men.The history of malaria contains a great lesson for humanitythat we should all be more scientific in our habits of thought, and more practical in our habits of government. Sir Ronald Ross, 1910Chapter 2 AnoEST: a genomic database for Anopheles gambiae functional studies

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Malaria: a publication of the Tropical Programme of the Wellcome Trust.

Cited by 5 publications

References 0 publications

Advancement Towards an Approved Vaccine to Target Plasmodium Falciparum Malaria

Advancement Towards an Approved Vaccine to Target Plasmodium Falciparum Malaria

Sharing of antigens between Plasmodium falciparum and Anopheles albimanus

Functional genomics and developmental transcriptomics of the mosquito malaria vector Anopheles gambiae

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