Antibody to human T-lymphotropic virus in a patient with Guillain-Barré syndrome (case report)

Nakauchi, Célia Maria; Linhares, Alexandre da Costa; Gomes, Mônica Lúcia; Maruyama, Koshi; Kanzaki, Luis Isamu Barros; Azevedo, Vânia Nakauth

doi:10.1590/s0036-46651991000400015

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Data from the present study provide evidence that HTLV-related neurological disorders in Belém, Northern Brazil appear to be of emerging public health importance 12,18,25 . The overall 8% seropositivity rate in our investigation is similar to that recorded in a previous, pilot local survey 18 where 9% of screened patients suffering from neurological disease were found to have HTLV-I/II antibodies.…”

Section: Discussionmentioning

confidence: 60%

“…Data from early studies conducted in North Brazil have postulated the relationship between HTLV-I infection and the development of Guillain-Barré syndrome in a 12 year-old boy 25 . The nationwide occurrence of HTLV-I infection in patients with HAM/TSP has been documented by several studies showing that both sexual promiscuity and blood transfusion appear to be the most important risk factors for transmission, with prevalence rates being higher among female subjects 1,2,3,7,8,9,31 .…”

Section: Introductionmentioning

confidence: 99%

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Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil

Macêdo

Ribeiro-Lima

Linhares

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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Serum- and/or- cerebrospinal fluid (CSF) samples obtained from 190 patients suffering from chronic, progressive neurological disease were screened for the presence of human T-cell lymphotropic viruses type I (HTLV-I) and type II (HTLV-II) antibodies over a six-year period (1996 to 2001) in Belém, Pará, Brazil. Patients were of both sexes (male subjects, 52%) with ages ranging from 2 to 79 years (mean, 35.9). Overall, 15 (7.9%) subjects - of whom 12 (80%) were female adults - reacted HTLV-I/II-seropositive when screened by enzyme-linked immunosorbent assay (ELISA). Serum samples from 14 of these patients were also analyzed using a recombinant Western blot (WB) assay that yielded HTLV-I-, HTLV-II-, and HTLV-I/II- reactivities for 10 (71.4%), 3 (21.4%) and 1 (7.2%) of them, respectively. The yearly rates of HTLV-I/II antibodies ranged from 2.6% (2001) to 21.7% (2000), with progressively increasing seropositivities from 1998 to 2000. Altogether, walking difficulty (n = 5 subjects), spasticity (n = 4) and leg weakness (n = 3) accounted for 80% of symptoms recorded among the 15 patients whose sera had antibodies to HTLV-I/II as detected by ELISA. These findings provide evidence that both HTLV-I and HTLV-II play a role in the development of chronic myelopathy in Belém, Pará, Northern Brazil.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil

Macêdo

Ribeiro-Lima

Linhares

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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“…However the majority are case reports, or case cluding neuroimaging such as computerized tomography series that sometimes relate HTLV-I infection to uveitis (CT) scan and / or magnetic resonance imaging (MRI), as [7], optic neuritis [8], idiopathic Parkinson [9], amyo-well as cerebral spinal fluid (CSF) examination and routiné trophic lateral sclerosis [10], Guillain-Barre syndrome blood tests. [11], inclusion body myositis and polimiositis [12,13], Three hundred and seventy seven patients were consid-Central nervous system (CNS) vasculitis [14] and multiple ered eligible for the study. Patients with signs of sclerosis [15].…”

Section: Introductionmentioning

confidence: 99%

Human T Lymphotropic Virus Type I (Htlv-I) Infection in Neurological Patients in Salvador, Bahia, Brazil.

Gomes

Melo²,

Proietti³

et al. 1999

Journal of Acquired Immune Deficiency Syndromes and Human Retro

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HTLV-I infection represents a major health concern in endemic areas throughout the world, such as Salvador, the main city of Bahia State, with socio-demographic characteristics similar to sub-Saharan African cities, located in the Northeast of Brazil. In order to provide an estimate of the frequency distribution, and range of neurological manifestations potentially related to HTLV-I infection in this city, we conducted a cross-sectional clinical-epidemiological study to determine the prevalence of this infection in patients with neurological diseases. Patients exhibiting vascular diseases, tumoral diseases or trauma were excluded. Over a period of 16 months, we studied 322 consecutive patients with chronic neurological diseases, who attended the neurological clinics of two major hospitals in Salvador. Overall, the prevalence of HTLV-I infection among the patients was 20.9% (67 / 320). However, the prevalence among the 104 patients with chronic myelopathy was 50.0% (52 / 104). It was observed that the major prevalence of HTLV-I was between the ages of 40 and 60 years with a female predominance. Our data indicate that, in Salvador city, HTLV-I is associated with chronic myelopathies or myeloneuropathies, which seem to be the only neurological diseases associated with HTLV-I.

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Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil

Gomes

Melo

Proietti

et al. 1999

Journal of the Neurological Sciences

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HTLV-I infection represents a major health concern in endemic areas throughout the world, such as Salvador, the main city of Bahia State, with socio-demographic characteristics similar to sub-Saharan African cities, located in the Northeast of Brazil. In order to provide an estimate of the frequency distribution, and range of neurological manifestations potentially related to HTLV-I infection in this city, we conducted a cross-sectional clinical-epidemiological study to determine the prevalence of this infection in patients with neurological diseases. Patients exhibiting vascular diseases, tumoral diseases or trauma were excluded. Over a period of 16 months, we studied 322 consecutive patients with chronic neurological diseases, who attended the neurological clinics of two major hospitals in Salvador. Overall, the prevalence of HTLV-I infection among the patients was 20.9% (67/320). However, the prevalence among the 104 patients with chronic myelopathy was 50.0% (52/104). It was observed that the major prevalence of HTLV-I was between the ages of 40 and 60 years with a female predominance. Our data indicate that, in Salvador city, HTLV-I is associated with chronic myelopathies or myeloneuropathies, which seem to be the only neurological diseases associated with HTLV-I.

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Antibody to human T-lymphotropic virus in a patient with Guillain-Barré syndrome (case report)

Cited by 3 publications

References 8 publications

Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil

Human T-cell lymphotropic virus types I and II infections in a cohort of patients with neurological disorders in Belém, Pará, Brazil

Human T Lymphotropic Virus Type I (Htlv-I) Infection in Neurological Patients in Salvador, Bahia, Brazil.

Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil

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