Immunology of fungal diseases

Kurstak, Edouard

doi:10.1590/s0036-46651991000300016

Cited by 7 publications

(3 citation statements)

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“…Opsonins or combinations of different opsonins have been shown to play an essential role in phagocytosis of pathogenic fungi by host effector cells [1][2][3]. In situations where there are decreased levels of complement components, other molecules may have to supply this function, e.g.…”

Section: Introductionmentioning

confidence: 99%

Opsonic effect of C-reactive protein on phagocytosis and intracellular killing of virulent and attenuated strains of Candida albicans by human neutrophils

Richardson¹

1991

FEMS Microbiology Letters

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Summary In the presence of autologous complement, maximal phagocytosis of Candida albicans blastospores of both a virulent and attenuated strain by human neutrophils in a monolayer assay was achieved after 30 min. The proportion of phagocytes containing intracellular blastospores was 33–36% with an average of 1.5 blastospores per phagocyte. In contrast to the attenuated strain of C. albicans, the virulent strain resisted opsonization by C‐reactive protein (CRP) and of those blastospores ingested, only 8% were killed. These findings support the concept that CRP may play a protective role in candidosis independent of complement. The fate of strains of different virulence may be a result of differences in CRP receptors or killing mechanisms.

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Section: Introductionmentioning

confidence: 99%

Opsonic effect of C-reactive protein on phagocytosis and intracellular killing of virulent and attenuated strains of Candida albicans by human neutrophils

Richardson¹

1991

FEMS Microbiology Letters

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“…O contágio pode ocorrer por contato direto com seres humanos, animais ou solo contaminado através de espécies antropofílicas, zoofílicas e geofílicas, respectivamente ou indiretamente por exposição a fômites contaminadas 3 . Esta distribuição dos dermatófitos está intimamente ligada ao seu habitat natural e determina não apenas os principais reservatórios das espécies, como também contribui para a compreensão das diferentes características clínicas das infecções dermatofíticas, como, por exemplo, o sítio cutâneo geralmente infectado, grau de infecção produzido e cronicidade das infecções 4 .…”

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“…O termo tinha originou-se da expressão "tinea", usada pelos romanos para descrever as infecções dermatofíticas, devido ao seu aspecto que lembrava o efeito das traças nas roupas de lã. Assim, as dermatofitoses são classificadas como: tinea capitis, tinea corporis, tinea manuum, tinea barbae, tinea pedis, tinea unguium, tinea cruris e outros 4 .…”

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Interação de Trichophyton rubrum com macrófagos peritoneais de camundongos

Campos¹

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Contribution of interferon-γ in protecting mice during pulmonary and disseminated infection with

Kawakami¹,

Tohyama²,

Teruya³

et al. 1996

FEMS Immunology and Medical Microbiology

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In the present study, the role of interferon-gamma (IFN-gamma) in the host resistance against Cryptococcus neoformans was examined using a murine model of pulmonary and disseminated infection. In this model, mice were infected intratracheally with live yeast cells, and the histological changes in the lungs and the number of microorganisms in the lung and brain were compared in mice treated and untreated with anti-IFN-gamma monoclonal antibody (mAb) to define the contribution of endogenously synthesized IFN-gamma in the natural course of infection. Administration of this mAb reduced the accumulation of inflammatory cells in the alveolar septa, peribronchial and perivascular areas, and promoted the expansive growth of microorganisms in the alveoli and destruction of alveolar structure. The neutralization of endogenous IFN-gamma by mAb increased the number of microorganisms in the lung and brain, and significantly shortened the survival time of infected mice. On the other hand, administration of IFN-gamma decreased the number of microorganisms in these organs, and significantly extended their survival time. Considered together, our results suggest that endogenous IFN-gamma protects mice from infection with C. neoformans by inducing a cellular inflammatory response, potentiating the clearance of microorganism from the lungs and preventing its dissemination into the central nervous system.

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Immunology of fungal diseases

Cited by 7 publications

References 0 publications

Opsonic effect of C-reactive protein on phagocytosis and intracellular killing of virulent and attenuated strains of Candida albicans by human neutrophils

Opsonic effect of C-reactive protein on phagocytosis and intracellular killing of virulent and attenuated strains of Candida albicans by human neutrophils

Interação de Trichophyton rubrum com macrófagos peritoneais de camundongos

Contribution of interferon-γ in protecting mice during pulmonary and disseminated infection with

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