Efeito inibidor do soro de ratos com insuficiência renal aguda e crônica sobre a tividade fagocitária "in vitro"

Ori, Maria; Seguro, Antônio Carlos; Rocha, Antonino dos Santos

doi:10.1590/s0036-46651990000600004

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…On the other hand, the inhibitory effect of Cdt venom on macrophage functions might be a consequence of the generation by the venom of serum factors, since the envenomation by Crotalus durissus terrificus can cause renal failure, and the serum from rats with renal failure inhibits, in vitro, the phagocytic activity of peritoneal macrophages. 25 However, sera obtained from mice injected with Cdt venom did not alter, in vitro, the spreading ability of macrophages. The inhibitory effect of the venom on the spreading index of peritoneal macrophage from athymic Nu/Nu mice suggests that this phenomenon is not mediated by lymphocyte-released products.…”

Section: Effect Of Cdt Venom On Peritoneal Macrophagementioning

confidence: 91%

The venom of South American rattlesnakes inhibits macrophage functions and is endowed with anti‐inflammatory properties

Silva

Gonçalves

Mariano

1996

Mediators of Inflammation

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The injection of Crotalus durissus terrificus venom into the foot pad of mice did not induce a significant inflammatory response as evaluated by oedema formation, increased vascular permeability and cell migration. The subcutaneous injection of the venom, or its addition to cell cultures, had an inhibitory effect on the spreading and phagocytosis of resident macrophages, without affecting the viability of the cells. This effect was not observed when the venom was added to cultures of thioglycollate elicited macrophages, but it was able to inhibit these macrophage functions when the cells were obtained from animals injected simultaneously with the venom and thioglycollate. These observations suggest that the venom interferes with the mechanisms of macrophage activation. Leukocyte migration induced by intraperitoneal injection of thioglycollate was also inhibited by previous venom injection. This down-regulatory activity of the venom on macrophage functions could account for the mild inflammatory response observed in the site of the snake bite in Crotalus durissus terrificus envenomation in man.

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Section: Effect Of Cdt Venom On Peritoneal Macrophagementioning

confidence: 91%

The venom of South American rattlesnakes inhibits macrophage functions and is endowed with anti‐inflammatory properties

Silva

Gonçalves

Mariano

1996

Mediators of Inflammation

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“…Cameron e cols. 27 observaram em uma população com sepse e insuficiência renal aguda, uma taxa de sobrevida de cerca de 35%.…”

Section: Características Clínicas E Fatores Associados à Retirada Do unclassified

Impacto dos fatores infecciosos e mecânicos na sobrevida do cateter temporário para hemodiálise em pacientes cardiopatas com injúria renal aguda

Silva¹

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Nutritional evaluation of single-cell protein produced by Spirulina platensis

Moreira¹

2011

Afr. J. Food Sci.

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The aim of this research was to evaluate the nutritional characteristics and possible toxic effects of microalgae Spirulina LEB-18, developed in south of Brazil. The biomass was evaluated for 40 days through nutritional responses, obtained by the development of Wistar rats and also by biochemical and hematological study of the blood of these animals. Four isoproteic diets were prepared (12% protein): (1) Control diet, 12% (w/w) of casein; (2) Diet S1, 8.8% (w/w) of Spirulina; (3) Diet S2, 17.6% (w/w) of Spirulina; (4) Diet S3, 26.4% (w/w) of Spirulina, distributed to the animals according to their treatment (n = 6). As to nutritional parameters the S1 treatment was more efficient. The groups did not differ in regard to biochemical determinations in blood, with the exception of S2, which showed creatinine levels lower than all others. In hematologic profile, the S3 treatment showed hematocrit and hemoglobin levels greater than the control diet. These results revealed no toxicity by the use of microalgae and it suggests the use of Spirulina as a potential source of single-cell protein.

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Efeito inibidor do soro de ratos com insuficiência renal aguda e crônica sobre a tividade fagocitária "in vitro"

Cited by 3 publications

References 5 publications

The venom of South American rattlesnakes inhibits macrophage functions and is endowed with anti‐inflammatory properties

The venom of South American rattlesnakes inhibits macrophage functions and is endowed with anti‐inflammatory properties

Impacto dos fatores infecciosos e mecânicos na sobrevida do cateter temporário para hemodiálise em pacientes cardiopatas com injúria renal aguda

Nutritional evaluation of single-cell protein produced by Spirulina platensis

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