Pentavalent antimonial nephrotoxicity in the rat

Veiga, Joel Paulo Russomano; Khanam, Rashida; Rosa, Tânia Torres; Junqueira, Luiz Fernando; Brant, P. C.; Raick, Alberto N.; Friedman, Horácio; Marsden, P.D.

doi:10.1590/s0036-46651990000400012

Cited by 17 publications

(12 citation statements)

References 10 publications

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“…However, when a dose of 200 mg/100 g was administered, there was significant glomerular dysfunction. 19 Nevertheless, in our sample of ACL patients evaluated before treatment, we demonstrated that U osm was significantly reduced, indicating that ACL, in and of itself, can impair urine concentrating ability. According to the literature on leishmaniasis, urinary acidification defect is less common than is urinary concentrating defect.…”

Section: Discussionmentioning

confidence: 65%

“…There are also reports of proteinuria and AKI in patients with ACL. 10,[16][17][18] In an experimental animal study, 19 high doses of an antimonial were shown to result in impaired urinary concentrating ability without a reduction in GFR. This abnormality was attributed to inhibition of antidiuretic hormone secretion and to a direct effect of the drug on tubular cells.…”

mentioning

confidence: 99%

“…In some animals, high doses of the antimonial also caused a reduction in the GFR. 19 To determine whether ACL itself causes tubular dysfunction, we studied the renal function of 37 ACL patients before antimonial treatment.…”

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confidence: 99%

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Renal tubular dysfunction in patients with American cutaneous leishmaniasis

Oliveira

Diniz

Teotônio

et al. 2011

Kidney International

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Renal dysfunction seen in patients with American cutaneous leishmaniasis (ACL) has been attributed to the use of antimonials for treatment. To determine whether ACL itself causes tubular dysfunction, we measured renal function in 37 patients with ACL prior to their treatment and compared results to that in 10 healthy volunteers of similar mean age. None of the patients presented with glomerular dysfunction; however, 27 had a urinary concentrating defect. There was no statistical difference between groups in the pre- and post-desmopressin test of urine osmolality, but the post-test urine osmolality of the controls was significantly higher. Urinary AQP2 levels, determined by western blot of isolated exosomes, were found to be significantly lower in patients than in controls, whereas that of the cotransporter (NKCC2) was significantly higher. A urinary acidification defect (post-test pH greater than 5.50 following calcium chloride) was found in 15 patients. Pretest plasma bicarbonate was below normal in 12 patients as was the pretest plasma pH in 14. Expression of the Na/H exchanger (NHE3), H(+)-ATPase, and pendrin were all significantly higher in patients with ACL than in controls. A combined urinary concentration and acidification defect was found in 12 patients. Thus, the urinary concentrating defect of ACL may be caused by decreased AQP2, with increased NKCC2 compensatory. Pendrin upregulation may be related to the urinary acidification defect with increased NHE3 and H(+)-ATPase also compensatory. Hence, ACL can cause asymptomatic renal tubular dysfunction.

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Section: Discussionmentioning

confidence: 65%

mentioning

confidence: 99%

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Renal tubular dysfunction in patients with American cutaneous leishmaniasis

Oliveira

Diniz

Teotônio

et al. 2011

Kidney International

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“…Veiga et al [24], reported 5 cases of ACL treated with pentavalent antimonial in conventional doses, but with a longer duration, which developed urinary concentrating inability. Lima Verde et al [14], found 68% of urinary concentrating capacity defect in patients with kala-azar before pentavalent antimonial therapy.…”

Section: Discussionmentioning

confidence: 99%

Renal function evaluation in patients with American Cutaneous Leishmaniasis after specific treatment with pentavalent antimonial

et al. 2012

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BackgroundRenal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction.MethodsA prospective study was conducted with 37 patients with ACL. Urinary concentrating and acidification ability was assessed before and after treatment with pentavalent antimonial.ResultsThe patients mean age was 35.6 ± 12 years and 19 were male. Before treatment, urinary concentrating defect (U/Posm <2.8) was identified in 27 patients (77%) and urinary acidification defect in 17 patients (46%). No significant glomerular dysfunction was observed before and after specific ACL treatment. There was no reversion of urinary concentrating defects, being observed in 77% of the patients before and in 88% after treatment (p = 0.344). Urinary acidification defect was corrected in 9 patients after treatment, reducing its prevalence from 40% before to only 16% after treament, (p = 0.012). Microalbuminuria higher than 30 mg/g was found in 35% of patients before treatment and in only 8% after treatment. Regarding fractional excretion of sodium, potassium, calcium, phosphorus and magnesium, there was no significant difference between pre and post-treatment period.ConclusionAs previously described, urinary concentrating and acidification defects were found in an important number of patients with ACL. Present results demonstrate that only some patients recover urinary acidification capacity, while no one returned to normal urinary concentration capacity.

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“…In a study involving 11 patients with ACL treated with pentavalent antimonial, 40 mg/kg for 30 days, the persisting urinary concentrating deficit was observed in 8 cases (72.7%) [15]. Veiga et al [16],reported 5 cases of ACL treated with pentavalent antimonial in conventional doses, but with a longer duration, which developed urinary concentrating inability. Lima Verde et al [17], found 68% of urinary concentrating capacity defect in patients with kala-azar before pentavalent antimonial therapy.…”

Section: Discussionmentioning

confidence: 97%

Renal function tests in patients with Cutaneous Leishmania after treatment with Glucantime

Hasani¹,

Kotayni²,

kabba³

2020

IJEAS

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Cutaneous leishmaniasis (CL) has historically been present in Syria, mainly in the western part of the country. The present study was conducted to evaluate kidney function parameters in patients infected with CL in Idlep-Syria. This is controlled study contain infected (60) and control (30) groups. The prevalence and distribution of infection were studied, kidney function testes were determined by colorimetric methods, (Biosystem ®). Among 100 of a total cases studied, the percent of infected cases are 60 % and not infected are 40%. The distribution of lesions on various parts of body in patients shows the highest percent of infection was in face (50%). There were highly significant increase in urea, uric acid and creatinine in infected group (p <0.0001) as compared to control one. In the war in Syria, the prevalence of infection was increased and had side effect on kidney parameter in infected patients treated with Glucantime.

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Pentavalent antimonial nephrotoxicity in the rat

Cited by 17 publications

References 10 publications

Renal tubular dysfunction in patients with American cutaneous leishmaniasis

Renal tubular dysfunction in patients with American cutaneous leishmaniasis

Renal function evaluation in patients with American Cutaneous Leishmaniasis after specific treatment with pentavalent antimonial

Renal function tests in patients with Cutaneous Leishmania after treatment with Glucantime

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