Isolation of Leishmania sp. from aqueous humor of a patient with cutaneous disseminated leishmaniasis and bilateral iridocyclitis (preliminary report)

Ferrari, Teresa Cristina de Abreu; Guedes, Antônio Carlos Martins; Oréfice, Fernando; Genaro, Odair; Pinheiro, Sônia Regina; Marra, Marisa A.; Silveira, Iara Lúcia Nunes; Miranda, Márcia Oliveira

doi:10.1590/s0036-46651990000400010

Cited by 19 publications

(16 citation statements)

References 4 publications

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“…isolated from aqueous humor in a (human) patient with disseminated CL and bilateral non-granulomatous iridocyclitis [12] was in Brazil. The ophthalmologic lesions were unresponsive to therapy despite resolution of the other systemic and cutaneous manifestations of this disease, which led to a fine needle aspirate of the anterior eye and isolation of Leishmania sp.…”

Section: Endo-ocular Parasitismmentioning

confidence: 99%

Neurologic Manifestations ofLeishmania spp.Infection

Petersen¹,

Greenlee²

2011

J. Neuroparasitolog.

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When listing common clinical signs of the spectra of Leishmania-derived diseases, neurologic malfunctions are not commonly included. Despite this, there are multiple reported instances both in human and veterinary medicine where neurologic manifestations, whether central or peripheral, are described. In this review, we describe neurologic manifestations seen during infection with Leishmania spp. with some discussion of the implicit effect of inflammation on the blood brain barrier in both medical and veterinary cases. Taken together, the material discussed here suggests that in patients from Leishmania-endemic areas, when observing neurologic symptoms, causation secondary to infection with Leishmania spp. should be highly considered.

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Section: Endo-ocular Parasitismmentioning

confidence: 99%

Neurologic Manifestations ofLeishmania spp.Infection

Petersen¹,

Greenlee²

2011

J. Neuroparasitolog.

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“…In some patients, phlyctenular and nummular keratitis have been observed, which appears to be because of a hypersensitivity reaction to the Leishmania antigens [7]. Other ocular manifestations include anterior uveitis, glaucoma, retinal hemorrhages, central retinal vein thrombosis, optic neuritis, chronic dacryocystitis, scleromalacia, epidermoid carcinoma and ptosis [8,9].…”

Section: Discussionmentioning

confidence: 99%

Ocular Leishmaniasis Presenting as Chronic Ulcerative Blepharoconjunctivitis: A Case Report

Ayele¹,

Wolde²,

Hagos³

et al. 2015

J Clin Exp Ophthalmol

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Leishmaniasis is caused by unicellular eukaryotic obligate intracellular protozoa of the genus Leishmania that is endemic in over 98 countries in the world-most of which are developing countries including Ethiopia. It is transmitted by phlebotomine sandflies. The eye may be affected in cutaneous, mucocutaneous and Post Kala-Azar Dermal Leishmaniasis. We report a case of ocular leishmaniasis with eyelid and conjunctival involvement that had simulated ulcerative blepharoconjunctivitis not responding to conventional antibiotics. The patient was diagnosed by microscopy of a sample obtained via direct smear from the lesions. He was treated with systemic sodium stibogluconate (20 mg/kg/day) for 45 days and was clinically cured with this treatment.

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“…Few studies have been carried out on experimental ocular leishmaniasis and natural infections observed in dogs. In humans, ocular leishmaniasis is associated with the presence of primary cutaneous leishmaniasis (Ferrari et al, 1990;Roizenblatt, 1979) or previous cases of American visceral leishmaniasis (Abdel-Hameed et al, 1990;El Hassan et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Ocular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection

Calabrese

Silva

Hardoim

et al. 2013

Experimental Parasitology

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There are few studies on human ocular leishmaniasis found in the literature. The purpose of this study was to describe experimental ocular leishmaniasis, caused by Leishmania amazonensis evaluating two different infection routes: intravitreal and instillation in C57BL/10 and BALB/c mice. In this work all animals presented low anti-Leishmania IgM and IgG titers regardless of the infection route or mouse strain. The histopathological eye analysis showed that the mice inoculated by the intravitreal route developed more severe lesions, presenting parasites in the anterior region of the eye 60 days after infection. The C57BL/10 mice presented cells containing parasitophorous vacuoles associated with pigmented cells and inflammatory infiltrate, which included mast cells. Ninety days after infection no parasites could be found in either mouse strain, which led us to hypothesize that parasites had been eliminated. In this context, we show that both intravitreal and instillation routes were effective in promoting ocular leishmaniasis infections in C57BL/10 and BALB/c mice. There were no differences in the parasite infection between the two mouse models and it mimicked the ocular lesions described in symptomatic dogs in endemic areas of visceral leishmaniasis.

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Isolation of Leishmania sp. from aqueous humor of a patient with cutaneous disseminated leishmaniasis and bilateral iridocyclitis (preliminary report)

Cited by 19 publications

References 4 publications

Neurologic Manifestations ofLeishmania spp.Infection

Neurologic Manifestations ofLeishmania spp.Infection

Ocular Leishmaniasis Presenting as Chronic Ulcerative Blepharoconjunctivitis: A Case Report

Ocular experimental leishmaniasis in C57BL/10 and BALB/c mice induced by Leishmania amazonensis infection

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