A new dynamic approach to the diagnosis of Symmer' fibrosis in schistosomiasis by ultrasound

Coutinho, Amaury

doi:10.1590/s0036-46651990000200001

Rev. Inst. Med. trop. S. Paulo

1990

DOI: 10.1590/s0036-46651990000200001

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A new dynamic approach to the diagnosis of Symmer' fibrosis in schistosomiasis by ultrasound

Amaury Coutinho

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Cited by 11 publications

(3 citation statements)

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“…There is usually no hepatic parenchymal cell damage and hepatic function usually remains normal. Many of the portal triads lack a vein lumen, causing presinusoidal portal hypertension and severe congestive splenomegaly, esophageal varices, and ascites 1–3 .…”

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confidence: 99%

“…What we call liver fibrosis nowadays, Symmers called cirrhosis and made the further mistake, understandable at the time, of describing what were surely S. mansoni eggs presenting lateral spicules in the hepatic tissue as “the ova of Bilharzia haematobia”. Spindle cells arranged concentrically around the eggs were ringed with fibrous tissue that formed “periportal cirrhosis” 1 .…”

mentioning

confidence: 99%

“…Subsequently pathologists in various countries, mainly Egypt, Puerto Rico and Brazil have used the terminology coarse periportal fibrosis, axial fibrosis, pipe stem fibrosis, or the best-known term, Symmers' fibrosis, in dealing with the hepatopathy of advanced Bilharziasis 1 .…”

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Letter to the Editor Analogies in Medicine: White Clay-Pipe Stem Cirrhosis

Andrade-Filho

2014

Rev. Inst. Med. trop. S. Paulo

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confidence: 99%

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Letter to the Editor Analogies in Medicine: White Clay-Pipe Stem Cirrhosis

Andrade-Filho

2014

Rev. Inst. Med. trop. S. Paulo

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Hepatitis B virus infection in schistosomiasis mansoni

Pereira

Melo

Lacerda

et al. 1994

Journal of Medical Virology

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Schistosomiasis and hepatitis B virus (HBV) infection are very common in Brazil but the interrelationships between the two infections are poorly understood. We have undertaken a detailed serological study of the prevalence of HBV markers in 189 Brazilian patients with chronic schistosomiasis mansoni, 46 with hepatointestinal (HIS) and 143 with hepatosplenic (HSS) schistosomiasis, 12 of the latter having decompensated liver disease (HSSD), and in 50 control patients. Sera were tested for HBsAg, anti-e, anti-HBc, anti-HBs and HBV-DNA. Eighty-three (44%) of the 189 schistosoma patients had at least one marker of HBV infection, 18 of whom (10%) were seropositive for HBsAg. All the controls were HBsAg negative, but ten (20%) had anti-HBc and anti-HBs. There was no significant difference in the frequency of these markers between HIS (14/46, 30.4%), HSSC (43/131, 34.5%), and the controls. Among the HBsAg-positive patients, one had HIS (HBV-DNA negative), seven had HSSC (one HBV-DNA positive) and ten had HSSD (six HBV-DNA positive), a significant association of HBV carriage with HSSD (P << 0.001). Mean (+/- SD) ALT values were significantly (P < 0.001) higher in HBsAg-positive HSSD patients (70.7 +/- 18 IU/liter) than in those with HSSC (29.5 +/- 15 IU/liter). Liver biopsies were performed in 12 HBsAg-positive patients (one with HIS, three with HSSC, and eight with HSSD) and in 50 HBsAg-negative HSSC patients. Seven of the eight HSSD patients had chronic active hepatitis with cirrhosis, and one had inactive cirrhosis. All three patients with HSSC and the one with HIS had chronic persistent hepatitis, with periportal fibrosis in three.(ABSTRACT TRUNCATED AT 250 WORDS)

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Hepatitis C virus infection in schistosomiasis mansoni in Brazil

Pereira

Saleh

Koskinas

et al. 1995

Journal of Medical Virology

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The involvement of the hepatitis C virus (HCV) in the severity of liver disease in chronic schistosomiasis was investigated in 215 Brazilian patients with S. mansoni infections, but without evidence of hepatitis B surface antigen (HBsAg). Forty-three had hepatointestinal (HIS) and 172 had hepatosplenic schistosomiasis (HSS), and 135 had compensated (HSSC), and 37 had decompensated (HSSD) liver disease. Fifty-two (24%) were found to have evidence of HCV infection (seropositive for anti-HCV antibodies and/or HCV-RNA). These comprised 35 (95%) of the 37 with HSSD, 16 (12%) of the 135 with HSSC, and 1 (2.4%) of the 43 with HIS, compared with only 1 (2%) of 50 control patients without S. mansoni. Testing of matched liver tissue and peripheral blood mononuclear cells (PBMCs) from 25 patients (6 HSSC and 19 HSSD) with HCV infections showed that 17 (68%) had "active" viral infections, in that negative strand HCV-RNA (the presumed replicative intermediate of the virus) could be detected in liver and/or PBMCs. Among these 25, negative strand HCV-RNA was found in 16 (84%) of the 19 with chronic active hepatitis, but in only 1 (17%) of the 6 with mild or inactive disease (P < 0.01). HCV-RNA was detected in matched spleen specimens from 9 of 10 patients (all of whom were also positive in PBMCs), suggesting that the spleen is an important extrahepatic reservoir of the virus.(ABSTRACT TRUNCATED AT 250 WORDS)

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A new dynamic approach to the diagnosis of Symmer' fibrosis in schistosomiasis by ultrasound

Cited by 11 publications

References 14 publications

Letter to the Editor Analogies in Medicine: White Clay-Pipe Stem Cirrhosis

Letter to the Editor Analogies in Medicine: White Clay-Pipe Stem Cirrhosis

Hepatitis B virus infection in schistosomiasis mansoni

Hepatitis C virus infection in schistosomiasis mansoni in Brazil

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