Esporotricosis felina: aspectos clínicos e zoonóticos

Larsson, Carlos Eduardo; Gonçalves, Mareia de Almeida; Araújo, Vera Cavalcanti de; Dagli, M.L.; Corrêa, Benedito; Neto, Celeste Fava

doi:10.1590/s0036-46651989000500010

Cited by 34 publications

(21 citation statements)

References 9 publications

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“…The main form of occurrence of feline sporotrichosis is as localized cutaneous lesions that evolve to disseminated, and the disseminated cutaneous form is of great severity in this species (Larsson et al., 1989). The general condition of the animals is a main determining factor for prognosis, as established by Schubach et al.…”

Section: Resultsmentioning

confidence: 99%

Feline Sporotrichosis in the Southern Region of Rio Grande Do Sul, Brazil: Clinical, Zoonotic and Therapeutic Aspects

Madrid

Mattei

Martins

et al. 2010

Zoonoses and Public Health

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Clinical cases of feline sporotrichosis, originating in the Pelotas region and diagnosed at the Laboratory of Infectious Diseases (UFPel), were studied in the period from 2002 to 2006. The animals were evaluated according to the clinical forms of the mycosis, time of lesion appearance, severity of the clinical diagnosis and evolution of cutaneous lesions throughout the treatment period. Mycological analyses, carried out through direct examination, cultivation of tissue samples and exudates of feline lesions all confirmed the diagnosis of sporotrichosis in the 15 animals under study. The cutaneous dissemination form was observed in 10 animals, of which three showed prostration, anorexia and dehydration. The zoonosis occurred in 20% of case studies, and the pet owners and one attendant at a veterinary clinic were infected, developing the fixed and disseminated cutaneous forms. The treatment of mycosis was carried out with itraconazole, 10 mg kg(-1), once a day, on 12 animals. The cure of the clinical symptoms was observed on 50% of the felines. This study demonstrates a good clinical response of felines with sporotrichosis, when they were treated itraconazole and calls the attention for the incidence of human sporotrichosis on people related to the veterinary activity as well as for pet owners.

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Section: Resultsmentioning

confidence: 99%

Feline Sporotrichosis in the Southern Region of Rio Grande Do Sul, Brazil: Clinical, Zoonotic and Therapeutic Aspects

Madrid

Mattei

Martins

et al. 2010

Zoonoses and Public Health

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“…Essa tendência da esporotricose em afetar mais machos (Miranda et al 2013) deve-se ao maior acesso ao ambiente extradomiciliar (Gross et al 2009), o que resulta em maior probabilidade de os machos se envolverem em brigas por fêmeas ou por território, principalmente aqueles não castrados (Schubach et al 2012). Além disso, os gatos possuem comportamentos como cobrirem seus dejetos com terra, lutar com outros animais e escalar e afiar as unhas em árvores (Larsson et al 1989, Antunes et al 2009, Schubach et al 2012, o que os predispõe a se tornarem portadores do fungo e o dispersar pelo ambiente (Schubach et al 2012). Vale salientar que neste estudo quatro gatos machos eram da mesma vizinhança, indicando a possibilidade de disseminação da doença através da interação animal ou de uma mesma fonte ambiental.…”

Section: Discussionunclassified

“…A lesão inicial de esporotricose caracteriza-se pela formação de nódulos subcutâneos, firmes, que lentamente tornam-se macios ou maleáveis ("gomosos"). À medida que isso ocorre, passam a drenar conteúdo seroso ou purulento e progridem para a formação de úlceras marcadamente exsudativas, com bordas ligeiramente definidas (Larsson et al 1989). A evolução da doença é geralmente grave (Schubach et al 2012).…”

Section: Discussionunclassified

“…estão no tamanho das leveduras (maiores), na presença da cápsula polissacarídica e de melanina na parede fúngica deste outro fungo (Kwon-Chung et al 1981, Galiza et al 2014. Outros diagnósticos diferenciais incluem candidíase, histoplasmose, leishmaniose, síndrome leproide felina e o carcinoma de células escamosas (em gatos despigmentados) (Larsson et al 1989, Antunes et al 2009, Gross et al 2009, Guarner & Brandt, 2011.…”

Section: Discussionunclassified

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Características clínico-epidemiológicas, histomorfológicas e histoquímicas da esporotricose felina

et al. 2016

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RESUMO.-Esporotricose é uma infecção fúngica causada por espécies do complexo Sporothrix, vista com maior frequência em gatos, equinos e cães. Os principais objetivos deste estudo retrospectivo foram caracterizar os aspectos histomorfológicos e histoquímicos da esporotricose em 10 gatos, além de avaliar os aspectos epidemiológicos, clíni-cos e os achados macroscópicos desses 10 casos, obtidos dos protocolos de biópsias e necropsias dos arquivos do Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria. A doença acometeu predominantemente gatos machos, sem raça definida e apresentou-se principalmente na forma cutânea disseminada. As lesões macroscópicas caracterizaram-se como nódulos cutâneos (ulcerados ou não) e como massas e placas ulceradas. Na histopatologia observou-se uma relação entre a quantidade de leveduras observada e dois padrões de resposta infla- glaukommers@yahoo.com Sporotrichosis is a mycotic infection caused by the Sporothrix complex species, affecting mostly cats, horses, and dogs. The main objectives of this retrospective study were to characterize the histomorphological and histochemical aspects of sporotrichosis in 10 cats, and also to evaluate epidemiological and clinical aspects, and gross findings obtained from the biopsy and necropsy protocols of these ten cases, obtained from the archives of the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria. The disease affected mostly male mongrel cats, and was mostly observed in the cutaneous disseminated form. Gross lesions were characterized by cutaneous nodules (ulcerated or not) and by ulcerated masses or plaques. By histopathology, there were a relationship between the fungal load and two patterns of inflammatory response. The first pattern was characterized by high fungal load, and most yeasts were inside of numerous macrophages with abundant, many times vacuolated cytoplasm. The amount of neutrophils ranged from mild to moderate in this pattern. The second pattern was characterized by numerous epiteliod cells and many neutrophils. The fungal load was low and most yeasts were observed in the extracellular space. The yeasts were round, oval or cigar-shaped. Several histochemical techniques, such as Grocott's silver stain, periodic Schiff acid, and Alcian blue were utilized and they made it easier to visualize, to characterize the morphology, and to quantify the organisms. The Giemsa stain allowed visualizing the agent, but it not allowed to sharply highlight them from other intralesional components. Organisms were negative for melanin granules through the Fontana-Masson stain in all cases. The histomorphological and histochemical study allowed demonstrating determinant fungal characteristics to the establishment of the diagnosis by means of this diagnostic tool.INDEX TERMS: Feline sporotrichosis, Sporothrix spp. complex, diseases of cats, subcutaneous mycosis.

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“…The traumatic inoculation of the conidia and hyphae of this fungus results in the development of subcutaneous mycoses; within the infected tissue, the fungus differentiates into its yeast form and may spread to other tissues (Ramos-e-Silva et al, 2007; Barros et al, 2011). Since the 1980s, domestic cats have been a source of mycosis transmission to humans (Nusbaum et al, 1983; Dunstan et al, 1986a,b; Larsson et al, 1989; Fleury et al, 2001). The largest epidemic of sporotrichosis due to zoonotic transmission was described in Rio de Janeiro between 1998 and 2004, in which 759 humans were diagnosed with sporotrichosis (Barros et al, 2004; Freitas et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic monoclonal antibody for sporotrichosis

Almeida¹

2012

Front. Microbio.

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Sporotrichosis is a chronic subcutaneous mycosis that affects both humans and animals worldwide. This subcutaneous mycosis had been attributed to a single etiological agent, Sporothrix schenckii. S. schenckii exhibits considerable genetic variability, and recently, it was suggested that this taxon consists of a complex of species. Sporotrichosis is caused by traumatic inoculation of the fungus, which is a ubiquitous environmental saprophyte that can be isolated from soil and plant debris. The infection is limited to cutaneous forms, but recently, more severe clinical forms of this mycosis have been described, especially among immunocompromised individuals. The immunological mechanisms involved in the prevention and control of sporotrichosis are not well understood. Some studies suggest that cell-mediated immunity plays an important role in protecting the host against S. schenckii. In contrast, the role of the humoral immune response in protection against this fungus has not been studied in detail. In a previous study, we showed that antigens secreted by S. schenckii induced a specific humoral response in infected animals, primarily against a 70-kDa molecule, indicating a possible role of specific antibodies against this molecule in infection control. In another study by our group, we produced a mAb against a 70-kDa glycoprotein of S. schenckii to better understand the effect of the passive immunization of mice infected with S. schenckii. The results showed a significant reduction in the number of CFUs in various mice organs when the mAb was injected before or during S. schenckii infection. Similar results were observed when T-cell-deficient mice were used. The drugs of choice in the treatment of sporotrichosis require long periods, and relapses are frequently observed, primarily in immunocompromised patients. The strong protection induced by the mAb against a 70-kDa glycoprotein makes it a strong candidate as a therapeutic vaccine against sporotrichosis.

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Esporotricosis felina: aspectos clínicos e zoonóticos

Cited by 34 publications

References 9 publications

Feline Sporotrichosis in the Southern Region of Rio Grande Do Sul, Brazil: Clinical, Zoonotic and Therapeutic Aspects

Feline Sporotrichosis in the Southern Region of Rio Grande Do Sul, Brazil: Clinical, Zoonotic and Therapeutic Aspects

Características clínico-epidemiológicas, histomorfológicas e histoquímicas da esporotricose felina

Therapeutic monoclonal antibody for sporotrichosis

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