Use of praziquantel in populations at risk of neurocysticercosis

Torres, Ronald

doi:10.1590/s0036-46651989000400014

Cited by 15 publications

(3 citation statements)

References 5 publications

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“…Between them, niclosamide is regarded as the treatment of choice because it is not absorbed from the intestinal tract and thus there is no chance of provoking neurological symptoms, if latent NCC is present in the same individual. [32][33][34] While mass praziquantel chemotherapy has been administered for schistosomiasis in wide areas of Africa, no controlled safety data on its use in cysticercosisendemic regions is yet available. Post-treatment coproantigen monitoring could prove helpful to detect treatment failures.…”

Section: Drugs For Treating Taeniasismentioning

confidence: 99%

Prevention and control ofTaenia soliumtaeniasis/cysticercosis in Peru

Gilman

González

Llanos-Zavalaga

et al. 2012

Pathogens and Global Health

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Taenia solium is endemic in most of the world, causing seizures and other neurological symptoms. Transmission is mainly maintained in rural areas by a human to pig cycle. Despite claims on its eradicability, sustainable interruption of transmission has not yet been reported. This manuscript reviews the conceptual basis for control, available diagnostic and control tools, and recent experiences on control in the field performed in Peru along the past decade

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Section: Drugs For Treating Taeniasismentioning

confidence: 99%

Prevention and control ofTaenia soliumtaeniasis/cysticercosis in Peru

Gilman

González

Llanos-Zavalaga

et al. 2012

Pathogens and Global Health

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“…However, the dose recommended for schistosomiasis treatment may increase the risk of seizures in people who are suffering from human cysticercosis where the larvae are lodged in the central nervous system (neurocysticercosis, NCC). Even a single dose, lower than that recommended for schistosomiasis treatment, has been reported to induce seizures [10]. Flisser and colleagues [11] reported suspected cases of NCC based on clinical signs following treatment with 5 mg/kg PZQ, and in a follow-up of 2452 participants subjected to an MDA using PZQ at 5 mg/kg where of 1.3 % reported complaints of severe headache after treatment.…”

Section: Introductionmentioning

confidence: 99%

Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa

et al. 2015

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BackgroundThis study aimed to map the distribution of Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa. These two major neglected tropical diseases are presumed to be widely distributed in Africa, but currently the level of co-distribution is unclear.MethodsA literature search on T. solium taeniosis/cysticercosis was performed to compile all known studies on the presence of T. solium and apparent prevalence of taeniosis and porcine cysticercosis in Africa. Studies were geo-referenced using an online gazetteer. A Bayesian framework was used to combine the epidemiological data on the apparent prevalence with external information on test characteristics to estimate informed district-level prevalence of taeniosis and porcine cysticercosis. Districts with T. solium taeniosis/cysticercosis presence were cross-referenced with the Global Neglected Tropical Diseases Database for schistosomiasis presence.ResultsThe search strategies identified 141 reports of T. solium in Africa from 1985 to 2014 from a total of 476 districts in 29 countries, 20 with porcine cysticercosis, 22 with human cysticercosis, and 16 with taeniosis, in addition to 2 countries identified from OIE reports. All 31 countries were considered, on national scale, to have co-distribution with schistosomiasis. Presence of both parasites was confirmed in 124 districts in 17 countries. The informed prevalence of taeniosis and porcine cysticercosis were estimated for 14 and 41 districts in 10 and 13 countries, respectively.ConclusionsWith the paucity of data, T. solium infection is grossly under-reported and expected to be more widespread than this study suggests. In areas where co-distribution occurs there is a need for increased emphasis on evaluation of integrated intervention approaches for these two helminth infections and allocation of resources for evaluating the extent of adverse effects caused by mass drug administration.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-015-0938-7) contains supplementary material, which is available to authorized users.

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“…It is important to note that there were two reports of neurological side-effects following PZQ 5mg/kg, including severe headaches in one case of undiagnosed neurocysticercosis [13] and another case of seizures that the authors suggest may not have been directly related to the treatment [37]. These reports, along with 2-3 other case reports of neurological side-effects following administration of PZQ for Taenia saginata and/ or Hymenolepis nana [75][76][77] have led to some concern about the safety of PZQ in areas endemic for cysticercosis. However, perspective is warranted here as case reports are a very low level of evidence of effect and chance cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis

Haby

León²,

Luciañez

et al. 2020

PLoS Negl Trop Dis

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Background Preventive chemotherapy is a useful tool for the control of Taenia solium taeniasis and cysticercosis. The aim of this systematic review is to assess the scientific evidence concerning the effectiveness and safety of different drugs in preventive chemotherapy for T. solium taeniasis in endemic populations. Methods A systematic review was conducted of controlled and uncontrolled studies, assessing the efficacy and adverse effects (among other outcomes) of albendazole, niclosamide and/or praziquantel for preventive chemotherapy of T. solium taeniasis. A comprehensive search was conducted for published and unpublished studies. Two reviewers screened articles, completed the data extraction and assessment of risk of bias. A meta-analysis of cure rate and relative reduction in prevalence was performed. The protocol for this review was registered on the International prospective register of systematic reviews (PROSPERO), number CRD42018112533. Results We identified 3555 records, of which we included 20 primary studies reported across 33 articles. Meta-analyses of drug and dose showed that a single dose of praziquantel 10mg/kg, albendazole 400mg per day for three consecutive days, or niclosamide 2g, resulted in better cure rates for T. solium taeniasis (99.5%, 96.4% and 84.3%, respectively) than praziquantel 5mg/kg or single dose albendazole 400mg (89.0% and 52.0%, respectively). These findings

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Use of praziquantel in populations at risk of neurocysticercosis

Cited by 15 publications

References 5 publications

Prevention and control ofTaenia soliumtaeniasis/cysticercosis in Peru

Prevention and control ofTaenia soliumtaeniasis/cysticercosis in Peru

Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa

Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis

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