A serological investigation of rotavirus infections in a shanty town population in Rio de Janeiro

Abstract

SUMMARYThe presence of antibodies against rotavirus was investigated by enzyme immunosorbent assay (ELISA) in two distinct groups of children living in a shanty town in Rio de Janeiro. One hundred and thirty six plasma samples were randomly collected from children of 0 to 33 months (first group) and 255 serum samples were collected from other 85 children at ages of 2, 6 and 9 months (second group). A high percentage of antibodies were found in the newborn children and this rate decreased progressively until the age of 11 months, after which it increased again. At the age of 7 months, geometric mean antibody titers increased indicating that infection had occurred.

Humoral immunity patterns based on antibody reactivity to rotavirus antigens in Brazilian children under 5 years of age

“…They observed that children with "short-term" immunity can become susceptible again by loosing antibody and be reinfected once or twice with rotaviruses. The results support and expand the findings of two other serological surveys of bELISA antibody and one of HIA antibody in serum specimens collected from infants and young children in three diffent cities in Brazil [Azeredo et al, 1989;Ishak et al, 1984;Gomes et al, 19831. The antibody patterns seen in the city of Recife are almost similar to those observed in other developing and developed regions of the world.…”

Humoral immunity patterns based on antibody reactivity to rotavirus antigens in Brazilian children under 5 years of age

“…The results support and expand the findings of two other serological surveys of bELISA antibody and one of HIA antibody in serum specimens collected from infants and young children in three diffent cities in Brazil [Azeredo et al, 1989;Ishak et al, 1984;Gomes et al, 19831. The antibody patterns seen in the city of Recife are almost similar to those observed in other developing and developed regions of the world. The frequency of antibody positive children was similar to that found in the United States, Germany, and Bangladesh [Blacklow et al, 1976;Brussow et al, 1988;Sack et al, 19801, somewhat higher than in Thailand [Echeverria et al, 19831, and lower than in Mexico [Ruiz-Gomes et al, 19811.…”

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

“…Estudos dirigidos ao primeiro aspecto se desenvolveram nas regiões norte , central (Ishak et al, 1984), e sudeste (Salles- Gomes et al, 1983;Azeredo et al, 1989) do Brasil. No contexto dessas investigações soroepidemiológicas, observou-se que aproximadamente 70% das crianças, já aos 4-5 anos de idade, infectaram-se por rotavírus, em consonância com achados de inúmeros outros estudos no mundo (Kapikian & Chanock, 1996).…”