Chagas' Disease: an acute transfusional case report

Abstract

Report of a case of acute transfusional Chagas'disease in a four-year-old child with a previous diagnosis of acute lymphocytic leukemia, transmitted in São Paulo, the Capital of São Paulo State, Brazil. Epidemiological investigation disclosed the donor's serological positivity and his previous residence in an area where Chagas' disease is endemic. The importance of adequate sorological screening in blood donors is evident. It should be stressed that this is the first case notified to the Superintendência de Controle de Endemias (SUCEN) (Superintendency for the Endemy Control) of the State Secretariat of Health, São Paulo, for the last five years.

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

“…3,4 T. cruzi infection is transmitted mainly via insect vector, where trypomastigotes of T. cruzi in the excreta of contaminated blood-sucking triatomines can penetrate sites of lesioned skin or mucosa in humans. 5 Other transmission routes have been also reported, such as congenital infection, 6,7 blood transfusions 8 or organ transplants, laboratory accidents, 9 and oral contamination. 10,11 Sustained efforts to control the vector have resulted in a decrease in the incidence of Chagas disease in several countries of Southern Cone in Latin America.…”