Neurocysticercosis: treatment with albendazole and dextrochloropheniramine (Preliminary Report)

Agapejev, Svetlana; Meira, Domingos Alves; Viera, Benedito Barra; Machado, Jussara Marcondes; Pereira, Paulo Câmara Marques; Mendes, Rinaldo Pôncio; Kamegasawa, Amélia; Curi, P. R.

doi:10.1590/s0036-46651988000500010

Cited by 7 publications

(4 citation statements)

References 5 publications

(1 reference statement)

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“…Instead, the dose previously used in hydatid disease (15 mg/kg/day) was used for cysticercosis. The initial length of therapy was 1 month, later reduced to 15 days and 1 week (2,3,14,21,29,55,63,89,90,94,95,98,111). There is limited experience with higher doses of both drugs (1,11,58).…”

Section: Vol 15 2002 Guidelines For Treatment Of Neurocysticercosismentioning

confidence: 99%

Current Consensus Guidelines for Treatment of Neurocysticercosis

et al. 2002

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Taenia solium neurocysticercosis is a common cause of epileptic seizures and other neurological morbidity in most developing countries. It is also an increasingly common diagnosis in industrialized countries because of immigration from areas where it is endemic. Its clinical manifestations are highly variable and depend on the number, stage, and size of the lesions and the host's immune response. In part due to this variability, major discrepancies exist in the treatment of neurocysticercosis. A panel of experts in taeniasis/cysticercosis discussed the evidence on treatment of neurocysticercosis for each clinical presentation, and we present the panel's consensus and areas of disagreement. Overall, four general recommendations were made: (i) individualize therapeutic decisions, including whether to use antiparasitic drugs, based on the number, location, and viability of the parasites within the nervous system; (ii) actively manage growing cysticerci either with antiparasitic drugs or surgical excision; (iii) prioritize the management of intracranial hypertension secondary to neurocysticercosis before considering any other form of therapy; and (iv) manage seizures as done for seizures due to other causes of secondary seizures (remote symptomatic seizures) because they are due to an organic focus that has been present for a long time

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Section: Vol 15 2002 Guidelines For Treatment Of Neurocysticercosismentioning

confidence: 99%

Current Consensus Guidelines for Treatment of Neurocysticercosis

et al. 2002

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“…In addition to the advancement in neurodiagnostic modalities, the systematic use of microsurgery has contributed to improved results in selected cases. Recent pharmacological experience with praziquantel and albendazole, which can provoke degeneration of cysticerci, 2,12,27,28,44,49,51,52,54,57,59,62 has shown that their efficacy is more marked in cases in which active cysts are present in the brain parenchyma. Although the effect of these drugs has been reported on ventricular or cisternal cysts, 28,44 there remains no consensus about their efficacy in these situations.…”

Section: Neurosurg Focus / Volume 12 / June 2002mentioning

confidence: 99%

“…2), ventricular, or cisternal giant cysticerci most often are racemose, 32,39 and their response to anticysticercal drugs such as praziquantel and albendazole remains controversial. 2,15,27,29,34,42,44,49,51,52,54,57,59,62 On the other hand, the risk of decompensation associated with increased ICP due to cyst degeneration-induced inflammatory reaction in patients with C. cellulosae 49 may contraindicate drug therapy and definitively contraindicate these drugs in patients with giant cysticerci and mass effect. In our opinion, the best treatment of the tumoral form of NCC is surgicalcyst excision via a direct approach, or at least, cyst evacuation and partial resection via a direct or stereotaxic approach.…”

Section: Forms Progressing To Intracranial Hypertensionmentioning

confidence: 99%

“…1,58 In our hospital 35.6% of these patients presented with increased ICP. 58 Despite the development of medications, such as praziquantel and albendazole, that can provoke degeneration of cysticerci, recent experience 2,12,27,28,44,49,51,52,54,57,59,62 has shown that their efficacy is more marked in cases in which active cysts are present in the brain parenchyma. Their effect on ventricular or cisternal cysts has been reported, 27,28,44 but there is no consensus regarding their efficacy in these situations.…”

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Surgical treatment of cerebral cysticercosis: long-term results and prognostic factors

Colli¹,

Carlotti²,

Assirati³

et al. 2002

FOC

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Object Cysticercosis is the most frequent parasitosis of the central nervous system. Although anticysticercal drugs have proven efficient in some cases, many patients with NCC require palliative, occasionally curative, surgical procedures. The authors analyzed the data and prognostic factors obtained during the follow-up period (range 1–255 months, median 38 months) in 160 patients with cerebral cysticercosis who underwent surgical treatment. Methods Different surgical approaches were indicated to control increased intracranial pressure (ICP) in most patients, and some patients had undergone decompressive surgery for local brain lesions. Most patients required more than one surgical procedure. Statistical analysis was performed using the Fisher exact, the log-rank, and the Kruskall–Wallis tests. Survival curves were calculated according the Kaplan–Meier method. The removal of a giant cyst from the parenchyma or cisterns for relief of increased ICP and for chiasm/optic nerve decompression improved most symptoms in patients. The removal of ventricular cysts was effective in the control of increased ICP in most patients. Patients with a ventricular cyst and ependymitis/arachnoiditis required placement of a ventriculoperitoneal (VP) shunt after the cyst was removed. This therapy effectively controlled increased ICP. Patients younger than 40 years of age at the time of treatment and male patients had worse outcomes. The outcome in patients who underwent VP shunt surgery or shunt surgery combined with reservoir implantation was worse than that in those who underwent cyst removal alone. Shunt-related infection was the most frequent complication, and the global mortality rate during the follow-up period was 21.2%. Although both complications were more frequent in the first 2 postoperative years, they occurred at any time. Conclusions Long-term prognosis in patients with cerebral cysticercosis who required surgery was not good. Cysts located in the basal cisterns and patient age younger than 40 years were poor prognostic factors.

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Current Issues in Cysticercosis: Proteins, Proglottids, Pigs, and Privies

Bryan

1992

Global Infectious Diseases

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Neurocysticercosis: treatment with albendazole and dextrochloropheniramine (Preliminary Report)

Cited by 7 publications

References 5 publications

Current Consensus Guidelines for Treatment of Neurocysticercosis

Current Consensus Guidelines for Treatment of Neurocysticercosis

Surgical treatment of cerebral cysticercosis: long-term results and prognostic factors

Current Issues in Cysticercosis: Proteins, Proglottids, Pigs, and Privies

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