On the tissular parasitism of Trypanosoma cruzi y strain in swiss mice

Abstract

A review of the tissular parasitism of Trypanosoma cruzi Y strain in Swiss mice was carried out. This strain parasitized preferentially smooth, skeletal and cardiac muscle fibers, with low transitory spleen and liver parasitism, as previously found by some Authors, although differing from other reports. These results can be related to the host genetical constitution and/or the degree of the strain virulence at the time of this study. Furthermore, we discuss that the high macrophagotropism reported for this strain in some instances could be an artificially induced condition resulting from its serial maintenance in mice, either for a longer time and/or by using young animals. The heavy parasitism and inflammation observed in the bladder, pancreas and spermatic duct of some inoculated mice, as well as the testis parasitization, were also noteworthy findings.

Could angiotensin-modulating drugs be relevant for the treatment of Trypanosoma cruzi infection? A systematic review of preclinical and clinical evidence

“…Thus, by using a myotropic strain (Dm28c) to infect host cells with epithelial origin, Scharfstein et al (2000) dissociates its experimental model from the natural parasite behaviour (Contreras et al, 1988). Conversely, Monteiro et al (2006) and Santos et al (2010) aligned host cell lineage with the reticulotropic/macrophagotropic characteristic of T. cruzi Y strain (Sousa and Alencar, 1984;Santiago et al, 2005), indicating an important element of construct and internal validity of the experimental model used. However, the inoculum size and time of infection were quite heterogeneous in all in vitro models, an important factor that makes these models even more divergent, since parasite load and cellular response to infection are profoundly influenced by the inoculum and time of contact between T. cruzi and host cells (Vazques et al, 2015).…”

Estudo bioquimico, morfologico e morfometrico em orgãos de camundongos infectados pela cepa MC de Trypanosoma cruzi

“…As anormalidades que ocorrem no metabolismo dos hidratos de carbono na fase crônica da doença de Chagas foram descritas pela primeira vez por Reis et al (1960), no qual foi feita uma associação da doença a casos de hipoinsulinismo e hiperglicemia. Diversos trabalhos já foram realizados, demonstrando a influência da infecção pelo T.cruzi sobre a glicemia (SOUZA; ALENCAR, 1984;MOREIRA;MACHADO, 1985;ALBUQUERQUE et al 1991;PRATA et al 1994;SANDOVAL et al, 1994;SANTOS et al 1999;OSAER et al, 2000;BURGOS, 2002;MENEZES et al, 2004;FAYE et al, 2005).…”

“…Em animais experimentais, Albuquerque et al (1991), verificaram que ratos infectados com a cepa Y do parasita manifestaram aumento dos níveis glicêmicos no 7º dia da infecção. Souza;Alencar (1984) avaliaram os parâmetros bioquímicos como TGO, TGP, uréia, glicose, creatinina e nutricionais de camundongos infectados pela cepa Y, observando que esses parâmetros foram nitidamente comprometidos nesses animais em relação ao grupo controle. Cazzulo (1978), pesquisou a degradação aeróbia da glicose por T. cruzi, demonstrando que este é capaz de degradar a glicose, tanto aerobicamente como anaerobicamente.…”